Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo

Intestinal barrier dysfunction is an essential pathological change in inflammatory bowel disease (IBD). The mucus layer and the intestinal epithelial tight junction act together to maintain barrier integrity. Studies showed that chitosan oligosaccharide (COS) had a positive effect on gut health, effectively protecting the intestinal barrier in IBD. However, these studies usually focused on its impact on the intestinal epithelial tight junction. The influence of COS on the intestinal mucus layer is still poorly understood. In this study, we explored the effect of COS on intestinal mucus in vitro using human colonic mucus-secreted HT-29 cells. COS relieved DSS (dextran sulfate sodium)-induced mucus defects. Additionally, the structural characteristics of COS greatly influenced this activity. Finally, we evaluated the protective effect of COS on intestinal barrier function in mice with DSS-induced colitis. The results indicated that COS could manipulate intestinal mucus production, which likely contributed to its intestinal protective effects.     

一维TiO2锐钛矿/金红石异相结的制备及光催化降解甲醛性能

TiO₂异相结主要通过高温方法制备,所制备材料的形貌和组成较难控制,尤其是在较低温度下一步制备一维TiO₂异相结仍具有一定的挑战性。采用简单、方便的一步水热法,在较低温度下(180℃)制备了一维纳米TiO₂异相结材料。X射线衍射(XRD)和高分辨透射电镜(HRTEM)分析表明,制备的材料以一维金红石相TiO₂纳米棒(长度：(400±50) nm,直径：(60±5) nm)为基本结构,粒径分布均匀的锐钛矿相TiO₂纳米粒子(直径：(9.5±0.5) nm)高密度、单分散地负载在纳米棒上。通过控制水热反应时间成功调控了异相结中锐钛矿相TiO₂的含量(20%～50%),进而实现了其光催化降解HCHO性能的调控。实验结果表明,当锐钛矿相TiO₂的含量为33%时(TiO₂-24,水热时间24 h制备的样品),异相结光催化剂表现出最佳的HCHO降解性能：在低光强LED灯(波长为365 nm,光强为12.26 mW·cm     

The Ideal Ionic Liquid Salt Bridge for the Direct Determination of Gibbs Energies of Transfer of Single Ions,Part I: The Concept

Described is a procedure for the thermodynamically rigorous, experimental determination of the Gibbs energy of transfer of single ions between solvents. The method is based on potential difference measurements between two electrochemical half cells with different solvents connected by an ideal ionic liquid salt bridge (ILSB). Discussed are the specific requirements for the IL with regard to the procedure, thus ensuring that the liquid junction potentials (LJP) at both ends of the ILSB are mostly canceled. The remaining parts of the LJPs can be determined by separate electromotive force measurements. No extra‐thermodynamic assumptions are necessary for this procedure. The accuracy of the measurements depends, amongst others, on the ideality of the IL used, as shown in our companion paper Part II.     

综合考虑宏细观缺陷的岩体动态损伤本构模型

针对节理岩体同时含有节理、裂隙等宏观缺陷及微裂隙、微孔洞等细观缺陷的客观事实, 提出了在节理岩体动态损伤本构模型中应同时考虑宏细观缺陷的观点。为此, 首先对基于细观动态断裂机理的经典岩石动态损伤本构模型—TCK(Taylor-Chen-Kuszmaul)模型进行了阐述, 其次基于Lemaitre等效应变假设推导了综合考虑宏细观缺陷的复合损伤变量(张量), 进而在此基础上建立了相应的节理岩体动态损伤本构模型, 并利用该模型讨论了载荷应变率及节理条数对岩体动态力学特性的影响规律。结果表明, 在不同载荷应变率下试件在变形初始阶段是重合的, 而后随着应变的增加, 试件峰值强度、峰值应变及总应变均随载荷应变率的增加而增加; 随着节理条数的增加, 试件峰值强度逐渐降低, 但降低趋势逐渐变缓并趋于某一定值。上述研究结论与目前的理论及实验研究结果的基本规律是一致的, 说明了本模型的合理性。     

混凝土断裂过程的力学模型与数值模拟

混凝土是一种典型的非均匀准脆性材料,其断裂过程是非常复杂的.评述了混凝土断裂以及断裂过程研究的进展状况,主要总结了一些研究混凝土断裂的宏观力学方法和模型,介绍了从混凝土的细观层次出发模拟其断裂过程的数值模型.最后,简单介绍了作者用细观数值方法模拟混凝土宏观断裂过程的研究成果.      

细观等效理论预测再生混凝土宏观力学参数北大核心CSCD

预测分析再生混凝土各组分对再生混凝土宏观力学参数的影响是开展再生混凝土基本力学性能的一种方式.为了分析再生混凝土各组分对再生混凝土宏观力学参数的影响,根据再生混凝土的细观结构组成,建立了细观等效模型,利用扭转变形、细观夹杂理论、弹性等效思想和M-T模型方法,推导了由原生骨料、老界面层、老水泥砂浆、新界面层和新水泥砂浆等组成的再生混凝土的宏观力学参数预测模型.预测结果表明,随着再生骨料的取代率增加,水泥砂浆的含量不断增加,再生混凝土孔隙率也随之增大,导致再生混凝土的Poisson比随之增大,弹性模量、剪切模量和体积模量不断降低.模型的预测结果较好地反映了再生混凝土宏观力学参数随再生骨料取代率的增加不断变化的这一趋势,也为再生混凝土宏观力学参数的预测提供了一条简单实用的新方法,有利于再生混凝土基本力学性能的研究分析.     

Dynamics of charge transfer at Au/Si metal-semiconductor nano-interface

An ab initio analysis of the periodic array of Au/Si nanostructure composed of gold clusters linked to silicon quantum dot (QD) co-doped by aluminium and phosphorus along [111] direction is presented in this paper. The density functional theory (DFT) is used to compute the electronic structure of the simulated system. Non-adiabatic coupling implemented in the form of dissipative equation of motion for reduced density matrix is used to study the phonon-induced relaxation in the simulated system. The density of states clearly shows that the formation of Au–Si bonds contributes states to the band gap of the model. Dynamics of selected photo-excitations shows that hole relaxation in energy and in space is much faster than electron relaxation, which is due to the higher density of states of the valence band.     

约瑟夫森结(阵列)与谐振器的耦合效应研究

利用一种新的电路模型系统研究了约瑟夫森结(阵列)与谐振器的耦合效应.以结的电压自锁定台阶幅度ΔI为目标值,得到了谐振电路的电阻R、谐振频率fr对耦合的影响规律,并给出了合理解释;以结阵列的相位互锁定强度IL为目标,研究了IL对锁定电压VL的依赖关系,同时,通过相关计算将其与通常电路模型下得到的结果进行了比较.     

n,p柱宽度对超结SiGe功率二极管电学特性的影响

结合SiGe材料的优异性能与超结结构在功率器件方面的优势,提出了一种超结SiGe功率二极管.该器件有两个重要特点:一是由轻掺杂的p型柱和n型柱相互交替形成超结结构,取代传统功率二极管的n^-基区;二是阳极p⁺区采用很薄的应变SiGe材料.该二极管可以克服常规Si p⁺n^-n⁺功率二极管存在的一些缺陷,如阻断电压增大的同时,正向导通压降随之增大,反向恢复时间也变长.利用二维器件模拟软件MEDICI仿真 关键词： 超结 锗硅二极管 n p柱宽度 电学特性     

Progress in superconducting qubits from the perspective of coherence and readout

Superconducting qubits are Josephson junction-based circuits that exhibit macroscopic quantum behavior and can be manipulated as artificial atoms.Benefiting from the well-developed technology of microfabrication and microwave engineering,superconducting qubits have great advantages in design flexibility,controllability,and scalability.Over the past decade,there has been rapid progress in the field,which greatly improved our understanding of qubit decoherence and circuit optimization.The single-qubit coherence time has been steadily raised to the order of 10 to 100μs,allowing for the demonstration of high-fidelity gate operations and measurement-based feedback control.Here we review recent progress in the coherence and readout of superconducting qubits.