Mathematical Modeling of Nylon 6/6,6 Copolymerization in Batch Reactor: Investigating Recipes without Water and with Cyclic Dimer

A model is used to simulate batch copolymerization of caprolactam with hexamethylene diamine (HMD) and adipic acid (ADA) to produce nylon 6/6,6. Four different recipes are considered: a recipe containing caprolactam and an aqueous solution of HMD and ADA, a recipe containing caprolactam and dry HMD/ADA salt, and two recipes with a portion of the caprolactam replaced by nylon 6 cyclic dimer (CD). Consuming CD would be advantageous because CD is an undesirable side product from nylon 6 production. Simulation results lead to three important findings: (i) operation using dry salt rather than aqueous salt solution leads to higher degree of polymerization, (ii) substantial quantities of CD can be consumed to produce nylon 6/6,6 copolymer, and (iii) including water in the recipe is beneficial for achieving improved consumption of CD. The results of this study will be helpful in designing experiments aimed at improving industrial nylon 6/6,6 copolymerization processes.     

Mechanical effects of acupuncture

Acupuncture, a physiotherapy, has been widely accepted all around the world. This study focuses on the influence of membrane structures and explains the acupuncture sensations from the aspect of mechanical properties. By mathematical modeling and numerical simulation, the scientific meaning of the acupuncture depth is investigated and phenomena and theory of acupuncture are discussed. The simulation results show that (a) the fascial structure is the main contributor to the force on the needle, the axial force will gradually increase before piercing the fascial, and suddenly decrease after piercing the fascial; (b) there is an inverse relationship between the needle radius and the maximum radial stress, which indicates that the needle should not be too sharp to cause local stress concentration and piece the fascia layer; and (c) the simulation results of comprehensively considering the static friction and sliding friction is identical with the experiment results. This study proposes a preliminary study of mechanical effects of acupuncture manipulation, clarifies key factors affecting the stress on the needle, and explains the objective requirement of acupuncture depth to effective treatment.     

Numerical optimisation of chemotherapy dosage under antiangiogenic treatment in the presence of drug resistance

We consider a two-compartment model of chemotherapy resistant tumour growth under angiogenic signalling. Our model is based on the one proposed by Hahnfeldt et al. (1999), but we divide tumour cells into sensitive and resistant subpopulations. We study the influence of antiangiogenic treatment in combination with chemotherapy. The main goal is to investigate how sensitive are the theoretically optimal protocols to changes in parameters quantifying the interactions between tumour cells in the sensitive and resistant compartments, that is, the competition coefficients and mutation rates, and whether inclusion of an antiangiogenic treatment affects these results. Global existence and positivity of solutions and bifurcations (including bistability and hysteresis) with respect to the chemotherapy dose are studied. We assume that the antiangiogenic agents are supplied indefinitely and at a constant rate. Two optimisation problems are then considered. In the first problem a constant, indefinite chemotherapy dose is optimised to maximise the time needed for the tumour to reach a critical (fatal) volume. It is shown that maximum survival time is generally obtained for intermediate drug dose. Moreover, the competition coefficients have a more visible influence on survival time than the mutation rates. In the second problem, an optimal dosage over a short, 30-day time period, is found. A novel, explicit running penalty for drug resistance is included in the objective functional. It is concluded that, after an initial full-dose interval, an administration of intermediate dose is optimal over a broad range of parameters. Moreover, mutation rates play an important role in deciding which short-term protocol is optimal. These results are independent of whether antiangiogenic treatment is applied or not.     

An Improved Model for Polyether Production from 1,3‐Propanediol

A dynamic mathematical model is developed for production of Cerenol polyether from 1,3‐propanediol in a batch reactor system. The model accounts for polycondensation reactions and side reactions in the liquid phase and for mass transfer of volatile species to the vapor. Parameters are estimated using measured liquid‐phase concentrations of monomer, oligomers, water, and end groups as well as the mass and composition of condensate collected from the overhead condenser system. The proposed model uses novel probability factors to keep the model equations relatively simple while accounting for the complex influence of superacid catalyst on reaction rates. The model is a significant advance over previous Cerenol models because it better accounts for mass‐transfer rates and for the dynamic behavior of the condenser. In addition, the proposed model accounts for the inhibitory influence of water on polycondensation kinetics due to hydration of hydroxyl ends. The model equations and parameter estimates provide a substantial improvement in fit to the data, especially for long reaction times and high catalyst levels, resulting in a 97% reduction in the value of the weighted least squared objective function compared to equations and parameters from a previous model.     

负二项分布类的条件概率封闭性

在研究只允许部分服务台进入休假状态的多服务台M／M／c排队系统时，我们发现了条件Erlang分布的一些有趣的性质，进一步研究我们发现相对应离散随机状态的负二项分布也具有很好的性质（概率封闭性．本文证明了一类负二项分布的概率封闭性．它们对导出复杂排队系统中离散状态下顾客等待时问分布及保险公司中破产概率上界的计算起着重要作用．     

旋涡流化床颗粒夹带和扬析的数学模型

本文结合气体湍流运动模型，颗粒运动的轨道模型和密相床层动力学的经验关联式，建立了旋涡流化床颗粒夹带和扬析的数学模型，发展了相应的求解程序。用本文提出的数学模型对普通鼓泡流化床中颗粒夹带的计算结果与前人的经验公式相符；对旋涡流化床和普通的鼓泡流化床颗粒扬析的计算结果与实验数据吻合较好。     

气象因素与儿童气管炎关系的研究

利用济南市卫生局提供的2003年儿童气管炎患者的病例资料和济南市气象局提供的2003年气象资料,对济南地区儿童气管炎疾病与气象资料的关系进行研究.通过相关性分析,用多元回归方法建立了儿童气管炎发病人数的日预报方程.然后对数据进行处理,按季节建立了儿童气管炎与气象要素之间的日预报方程.     

Weak and strong stationarity in generalized bilevel programming and bilevel optimal control

In this article, we consider a general bilevel programming problem in reflexive Banach spaces with a convex lower level problem. In order to derive necessary optimality conditions for the bilevel problem, it is transferred to a mathematical program with complementarity constraints (MPCC). We introduce a notion of weak stationarity and exploit the concept of strong stationarity for MPCCs in reflexive Banach spaces, recently developed by the second author, and we apply these concepts to the reformulated bilevel programming problem. Constraint qualifications are presented, which ensure that local optimal solutions satisfy the weak and strong stationarity conditions. Finally, we discuss a certain bilevel optimal control problem by means of the developed theory. Its weak and strong stationarity conditions of Pontryagin-type and some controllability assumptions ensuring strong stationarity of any local optimal solution are presented.     

Optimal control applied on an HIV‐1 within‐host model

The treatment of human immunodeficiency virus (HIV) remains a major challenge, even if significant progress has been made in infection treatment by ‘drug cocktails’. Nowadays, research trend is to minimize the number of pills taken when treating infection. In this paper, an HIV‐1 within host model where healthy cells follow a simple logistic growth is considered. Basic reproduction number of the model is calculated using next generation matrix method, steady states are derived; their local, as well as global stability, is discussed using the Routh–Hurwitz criteria, Lyapunov functions and the Lozinskii measure approach. The optimal control policy is formulated and solved as an optimal control problem. Numerical simulations are performed to compare several cases, representing a treatment by Interleukin2 alone, classical treatment by multitherapy drugs alone, then both treatments at the same time. Objective functionals aim to (i) minimize infected cells quantity; (ii) minimize free virus particles number; and (iii) maximize healthy cells density in blood. Copyright © 2015 John Wiley & Sons, Ltd.     

Development of boundary element method to dynamic problems for porous media

Biot's consolidation theory is extended to a general class of viscoelastic bodies defined by Riemann-Stieltjes integral convolutions. From a new reciprocity theorem, proved for the governing equations including the inertia terms, the basic integral representations of the displacement fields and pore pressure are obtained. It is shown that, in the absence of internal inputs, a formulation of the dynamic problem in terms of the boundary unknown fields only is possible.