A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

Despite the promising prospect of small interfering RNA(siRNA) for the treatment of diverse diseases,it remains challenging to develop novel delive ry materials to desired tissues and cells.In this study,a novel iron oxyhydroxide(FeOOH) nanoparticle(NP) whose surface was modified with branched polyetherimide(PEI) was developed to deliver siRNA into the cancer cells.It was demonstrated that PEI-FeOOH(PFeOOH) efficiently complexed siRNA,mediated effective cellular uptake and endosomal escape,thereby triggering robust gene silencing in vitro.In addition,PFeOOH/siRNA formulation loading with anti-RRM2 siRNA effectively inhibited the growth of tumor tissues,and exhibited excellent safety profiles in vivo.Therefore,this study conceptually provided a FeOOH-based nucleic acid delivery vesicle which can potentially use to achieve diagnosis and therapy simultaneously.     

模拟光纤传输模块的原理与设计

光纤与同轴电缆相比,具有抗干扰能力强、传输损耗小、质量轻等优点。采用高线性激光二极管直接调制的方法设计和研制了一种简单、实用和低成本的模拟信号光纤传输模块。测试结果表明,模块的3dB带宽为DC～3MHz,0～5V范围内模块的非线性误差最大为1．2％,可以用于复杂电磁环境中模拟信号的无干扰传输。     

一种可调横向剪切量的新型偏振干涉成像光谱仪

为了克服传统成像光谱仪稳定性差,干涉条纹杂乱复杂等缺点,提出了一种基于可调横向剪切量萨伐尔(Savart)偏光镜的新型偏振干涉成像光谱仪。具体分析推导了光线入射角变化对这种新型的可调横向剪切量萨伐尔偏光镜的光程差、偏振度以及对系统干涉条纹的影响;简要论述了这种新型偏振干涉成像光谱仪的工作机理和运行方式,从原理上论证了它具有重量轻、体积小、抗震性好、适用范围广、分束光线平行均匀分布、干涉图样清晰、处理简便等诸多优点,为新型可调横向剪切量的偏振干涉成像光谱仪的设计、研制、调试和工程化提供理论依据和实践指导。     

具有单一复合调制区的多模干涉效应耦合器 1×3光开关的分析

基于多模干涉自映像原理,分析了一种仅含一个复合调制区的1×3光开关。该开关处于不同工作状态时,调制臂上所加相位调制量之间存在倍数关系,于是可将调制臂上的相移器组合成一个复合调制区,通过连续改变复合调制区的折射率变化量,因此可以将来自任一输入端的光场轮流切换到任意输出端口。以Al0.07Ga0.93As/GaAs脊形波导结构为例,采用BEAMPROP软件,对该开关进行了优化和理论验证。消光比高达30.3 dB;相邻通道之间的串扰低于-29.8 dB;在1.31μm工作波长处约50 nm的波谱范围内,串扰低于-20 dB。该结构可简化传统多通道开关的调制方法,降低外加控制方法的复杂程度。     

超连续谱干涉方法测量古依相移

利用两束超连续光干涉得到的信号,测量了透镜焦点附近飞秒激光脉冲的古依(Gouy)相移。根据得到的光谱干涉信号,利用傅里叶变换得到相对相位值。激光光束在聚焦透镜后的束腰半径可以由成像方法测得。根据测量得到的激光光束束腰半径,用非线性拟合的方法得到了古依相移曲线,拟合曲线与实验结果符合得非常好。给出了古依相位在焦点前后1 mm区域内的移动量。     

无汞盐密封法测定高氯浓度水样的化学需氧量

提出了一种以重铬酸钾为氧化剂,以6%硫酸银代替硫酸汞作为掩蔽-催化剂消除高氯离子干扰,测定化学需氧量(COD)的无汞密封新方法。研究了反应温度、反应时间和硫酸银浓度等测定条件。该法可以避免汞盐对环境的污染,适合测定多种类型的水样。该法测定结果的相对标准偏差为1.4%(n=8),平均加标回收率为98.5%.     

Extracting the phase distribution of the electron wave packet ionized by an elliptically polarized laser pulse

We use an interferometic scheme to extract the phase distribution of the electron wave packet from above-threshold ionization in elliptically polarized laser fields. In this scheme, an electron wave packet released from a circularly polarized laser pulse acts as a reference wave and interferes with the electron wave packet ionized by a time-delayed counter-rotating elliptically polarized laser field. The generated vortex-shaped interference pattern in the photoelectron momentum distribution enables us to extract the phase distribution of the electron wave packet in the elliptically polarized laser pulse with high precision. By artificially screening the ionic potential at different ranges when solving the time-dependent Schördinger equation, we find that the angle-dependent phase distribution of the electron wave packet in the elliptically polarized laser field shows an obvious angular shift as compared to the strong-field approximation, whose value is the same as the attoclock shift. We also show that the amplitude of the angle-dependent phase distribution is sensitive to the ellipticity of the laser pulse, providing an alternative way to precisely calibrate the laser ellipticity in the attoclock measurement.     

High-precision detection technology of NO concentration based on UV differential-adaptive interference cancellation北大核心CSCD

In order to realize high-precision monitoring of vehicle emission, a high-precision and wide-range NO measurement method was proposed. Aiming at the problem that the absorption peaks of SO2 and NO in emission overlapping in the UV band, and it was impossible to directly perform single-component gas inversion, the differential optical density (DOD) of mixed gas in the NO sensitive band (200 nm～230 nm) was first calculated by the ultraviolet differential optical absorption spectroscopy (UV-DOAS) method. Then, the adaptive interference cancellation technology was introduced to achieve rapid separation of mixed gas DOD. Finally, the least square method was used to perform the concentration inversion of separated NO. This method could achieve rapid inversion of NO concentration (volume fraction of gas) in the range of 100×10−6 to 3 000×10−6. After testing, the absolute value of the relative error of inversion is less than 10% in the concentration range of 100×10−6 to 200×10−6, and less than 5% in the concentration range of 300×10−6 to 3 000×10−6. This method has the characteristics of large measurement range and fast speed, and can meet the measurement requirements of NO concentration in the range of 3 000×10−6 in vehicle emission. © 2022 Editorial office of Journal of Applied Optics. All rights reserved.     

Effects of optical axis direction on optical path difference and lateral displacement of Savart polariscope

A simple method is applied to calculating the optical path difference (OPD) of a plane parallel uniaxial plate with an arbitrary optical axis direction. Then, the theoretical expressions of the OPD and lateral displacement (LD) of Savart polariscope under non-ideal conditions are obtained exactly. The variations of OPD and LD are simulated, and some important conclusions are obtained when the optical axis directions have an identical tolerance of \pm 1^{{\circ}}. An application example is given that the tolerances of optical axis directions are gained according to the spectral resolution tolerances of the stationary polarization interference imaging spectrometer (SPIIS). Several approximate formulae are obtained for explaining some conclusions above. The work provides a theoretical guidance for the optic design, crystal processing, installation and debugging, data analysis and spectral reconstruction of the SPIIS.     

ICP—AES直接测定土壤,沉积物中常,微量元素的光谱干扰和？…

本文研究了感耦等离子体原子发射光谱（ＥＣＰ－ＡＥＳ）法直接测定土、沉积物中常、微量元素的光谱干扰,以及用多元光谱拟合（ＭＳＦ）校正的方法。讨论了积分时间及谱线漂移对ＭＳＦ法的影响。比较了离峰扣背景法与ＭＳＦ法的效果,对水系沉积物ＧＢＷ０７３０６测定结果表明,ＭＳＦ法得出的结果更接近推荐值,且其检出限及相对标准偏差比离峰扣背景法分别改善了１．３～９．０倍和１．１～４．９倍。