多通道表面放电光泵浦源触发特性研究

介绍了多通道表面放电光泵浦源的设计,理论分析了触发电压幅值及上升时间、绝缘基板厚度等参数对所设计光泵浦源触发特性的影响。分析表明：在触发电压作用下,通道两电极处电场出现强烈畸变,而通道中间电场基本为零。采用高速相机拍摄泵浦源的放电图像以及电流线圈测量各通道的放电电流这两种方法实验研究了泵浦源的同步性及放电均匀性。当氮氩混合气体总气压为0.1 MPa (氮氩体积比为3∶7),充电电压20 kV,触发电压30 kV,前沿约10 ns时,成功实现了10通道均匀放电,抖动约20 ns。实验结果表明：在保证放电装置绝缘良好的情况下,若充电电压和触发电压越高,触发电压上升时间越短,触发电极至通道的有效距离越短,则多通道放电的抖动就越小,放电均匀性越好。     

Variation of Xe concentration in a high pressure Ar/Xe laser with coaxial e-beam pumping

A series of measurements on the high pressure (up to 18 bar) coaxial e-beam pumped Ar/Xe laser has been made at high power loading (up to 25 MW/cm~2) for various Xe mole fraction in Ar. We found that the optimum laser gas composition in our system was 0.4% Xe in Ar which was independent of the total gas pressure. At the optimum gas composition the output energy increased with increasing total gas pressure up to 16 bar, but the intrinsic efficiency reached a maximum at the total gas pressure of 8 bar. It was also found that at the optimum power deposition for both the 2.63μm and 2.65μm transitions the ratio of the integrated optical energy to that of the 1.73μm transition had a minimum in most cases at the optimum gas mixture for various gas pressures. This ratio increased with increasing gas pressure. The experimental results suggested that besides the 2-body Xe quenching at high Xe fraction and electron collision mixing at high power depositions the heavy particle quenching from Ar at high gas press     

Dissipation, decoherence and preparation effects in the spin-boson system

The dynamics of the reduced density matrix of the driven dissipative two-state system is studied for a general diagonal/off-diagonal initial state. We derive exact formal series expressions for the populations and coherences and show that they can be cast into the form of coupled nonconvolutive exact master equations and integral relations. We show that neither the asymptotic distributions, nor the transition temperature between coherent and incoherent motion, nor the dephasing rate and relaxation rate towards the equilibrium state depend on the particular initial state chosen. However, in the underdamped regime, effects of the particular initial preparation, e.g. in an off-diagonal state of the density matrix, strongly affect the transient dynamics. We find that an appropriately tuned external ac-field can slow down decoherence and thus allow preparation effects to persist for longer times than in the absence of driving. Received 23 October 1998 and Received in final form 26 February 1999     

Efficient 1047 nm CW laser emission of Nd:YLF under direct pumping into the emitting level

We demonstrate a 1047 nm Nd:LiYF₄ (Nd:YLF) laser by directly pumping into the upper lasing level with a tunable Ti:Sapphire laser. The results obtained for direct upper laser level pumping at 863, 872 and 880 nm of Nd:YLF were compared with traditional 806 nm pump band excitation. Highly efficient 1047 nm continuous-wave (CW) laser emission under direct pumping at 880 nm in an 8 mm thick, 1.0 at.% Nd:YLF crystal is obtained. The slope efficiency is improved from 55.6% for traditional pumping at 806 nm to 76.3% for direct pumping at 880 nm.     

A standing wave model for acoustic pumping effect in microchannels

An acoustic impedance pump is comprised of a compressible section coupled at both ends to sections of different acoustic impedances. Liquid can be pumped from one end to another if the compressible section is actuated at certain locations. This paper presents an analytical model on the acoustic pumping effect in microchannels. A one-dimensional wave equation is developed for acoustic pressures in the compressible section, taking into account the actuations as acoustic source terms. The solution for the acoustic pressure is a set of standing waves established inside the compressible section, corresponding to the actuations. The pumping effect is attributed to the second-order terms of the acoustic pressures. Two control parameters are identified. One is the resonance frequency associated with the sound wave speed and length of the compressible section, and the other is the damping factor. The analytical results are compared with the experimental data, and a qualitative agreement is observed in terms of frequency characteristics of the pumping pressure.     

间接原子吸收光谱法测定头孢克肟含量

提出了测定药物制剂中头孢克肟含量的间接原子吸收分析方法.在碱性介质中加热后,头孢克肟发生水解反应,其水解产物与酒石酸铜定量反应生成沉淀,离心分离后,利用原子吸收法通过测定沉淀中铜含量间接确定头孢克肟的含量.头孢克肟的浓度在39.7-226.7μg/mL范围内与吸光度呈良好的线性,线性相关系数r=0.9990,测定结果的...     

Astragalus membranaceus ultrafine powder alleviates hyperuricemia by regulating the gut microbiome and reversing bile acid and adrenal hormone biosynthesis dysregulation

Ethnopharmacological relevanceMetabolic syndrome is closely related to the intestinal microbiota and disturbances in the host metabolome. Hyperuricemia (HUA), a manifestation of metabolic syndrome, can induce various cardiovascular diseases and gout, seriously affecting a patient’s quality of life. Astragalus membranaceus has a long history as a commonly used traditional Chinese medicine to treat kidney disease in China and East Asia.Materials and methodsWe compared the therapeutic effect of benzbromarone and two different doses Astragalus membranaceus ultrafine powder (AMUP) in rats with HUA. Ultra-performance liquid chromatography-mass spectrometer was used to analyze the AMUP metabolism in the plasma, urine, and feces. Further, 16S ribosome RNA sequencing and feces metabolomic were performed to capture the variation of the gut microbiota and metabolites changes before and after drug administration.ResultsAMUP had a notable impact on reducing blood uric acid levels while protecting the liver and kidney. Drug metabolism analysis demonstrated that effective constituent flavonoids are distributed in the blood, whereas saponins remain in the intestine. Gut microbiota analysis showed that low-dose AMUP ameliorated HUA-induced gut dysbiosis by reducing the abundance of harmful bacteria and increasing that of some beneficial bacteria with anti-inflammatory properties, such as Clostridia, Lachnospiraceae, and Muribaculaceae. In addition, HUA-induced changes in metabolite contents in bile acid and adrenal hormone biosynthesis pathways were restored after treatment with AMUP.ConclusionLow-dose AMUP exerts remarkable therapeutic effects on HUA by regulating the gut microbiome and mediating gut metabolism pathways associated with uric acid excretion.     

An integrated plastic microchip for enhancing electrophoretic separation using tunable pressure-driven backflows

Microfluidic CE (MCE) is an effective solution for rapid and sensitive determination of multiple analytes. Herein, a dynamic coated cyclic olefin copolymer microchip was developed having an on-chip micropump for fluid velocity adjusting in electrophoretic separations. This micropump was fabricated by constructing a polyacrylamide gel membrane at one channel terminal. Once applying electric field across the membrane, a pressure-driven flow generated automatically to balance the electroosmotic flow (EOF) mismatch at the channel-membrane interface. The influence of gel precursor concentration and operating voltages on the fluid velocity was carefully evaluated. Moreover, the highly integration of injection, separation, and pumping units of the MCE system minimized the dead volume and provides satisfied column efficiency. Experiments showed that by adjusting of pumping voltage reduced the fluid velocity by a factor of 6, resulting six- and threefold resolving power enhancements of rhodamine dye mixture and amino acid mixture, respectively. Furthermore, the developed MCE method was applied for rhodamines and amino acids quantitation in food and cosmetics, with standard addition recoveries of 87.3–106.9% and 89.9–117.4%, respectively. These results were also confirmed by standard HPLC method, revealing the application potential in fast and onsite analysis of complex samples.     

Electrokinetic characterization of hybrid NOA 81-glass microchips: Application to protein microchip electrophoresis with indirect fluorescence detection

A low-cost and straightforward hybrid NOA (Norland optical adhesive) 81-glass microchip electrophoresis device was designed and developed for protein separation using indirect fluorescence detection. This new microchip was first characterized in terms of surface charge density via electroosmotic mobility measurement and stability over time. A systematic determination of the electroosmotic mobility (μ_eo) over a wide pH range (2–10) and at various ionic strengths (20–50 mM) was developed for the first time via the neutral marker approach in an original simple frontal methodology. The evolution of μ_eo was proved consistent with the silanol and thiol functions arising from the glass and the NOA materials, respectively. The repeatability and reproducibility of the measurements on different microchips (RSD < 14%) and within 15 days (less than 5% decrease) were successfully demonstrated. The microchip was then applied for the efficient electrophoretic separation of proteins in a zonal mode coupled with indirect fluorescence detection, which is, to our knowledge, the first proof of concept of capillary zone electrophoresis in this hybrid microsystem.