Modelling the spread of sexually transmitted diseases on scale-free networks

In this paper a new model for the spread of sexually transmitted diseases (STDs) is presented. The dynamic behaviors of the model on a heterogenous scale-free (SF) network are considered, where the absence of a threshold on the SF network is demonstrated, and the stability of the disease-free equilibrium is obtained. Three immunization strategies, uniform immunization, proportional immunization and targeted immunization, are applied in this model. Analytical and simulated results are given to show that the proportional immunization strategy in the model is effective on SF networks.     

加热炉热过程动态操作数学模型

根据加热炉生产特点,建立了钢坯加热过程的动态操作数学模型,分析了待轧时间变化时炉内钢坯温度分布情况。并针对加热炉待轧的灰色性,采用多目标灰色局势决策方法,得出了相应合理的待轧优化控制策略。模拟结果表明:该方法具有良好的动态性能,适合于在线控制。     

浮力调节软件的单元测试技术研究

为了提高嵌入式软件的单元测试效率,同时能达到很好的测试效果,针对嵌入式软件制定单元测试充分性准则和单元测试策略,并使用测试工具对嵌入式软件进行单元测试具有实际意义;以浮力调节软件为例,通过研究基于控制流的单元测试充分性准则,结合浮力调节软件的单元测试需求,提出了针对浮力调节软件的单元测试充分性准则;同时,考虑到圈复杂度和函数节点数对函数正确实现的影响,制定了基于优先级的单元测试策略;利用自动化单元测试工具Testbed搭建了浮力调节软件动态测试环境,通过代码覆盖率分析,帮助创建测试用例以达到单元测试充分性要求,从而实现了浮力调节软件单元测试自动化;在自动化测试工具的帮助下,结合单元测试充分性准则和单元测试策略,最终实现严格而高效的单元测试。     

基于休眠机理的三维小基站蜂窝网络能效优化

小基站通常部署在写字楼、商贸区等城市密集区域以弥补传统宏基站在覆盖和传输方面的不足.小基站的分布一般是根据高峰时的网络负荷设计的,这必然导致网络负荷较低时的资源浪费.讨论了在平均接入率和信道容量双重约束下基于休眠机理的三维小基站蜂窝网络的能效优化问题.借助泊松点过程理论推导了三维小基站网络下行信道容量和平均接入率的数学表达式.通过分析下行信道容量和平均接入率的单调性得出同时满足传输信道容量和接入率要求的最佳休眠概率.分析了小基站最大用户连接数的最佳值,通过对该参数的合理配置,可以在满足通信指标的前提下最大程度地降低网络能耗.仿真结果表明,设计的基站休眠机理可以使小基站网络的能耗下降约21%.     

A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs

A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE(P_S~1-cIDPRE) was developed.The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy.     

A hybrid genetic algorithm–neural network strategy for simulation optimization

Simulation optimization aims at determining the best values of input parameters, while the analytical objective function and constraints are not explicitly known in terms of design variables and their values only can be estimated by complicated analysis or time-consuming simulation. In this paper, a hybrid genetic algorithm–neural network strategy (GA–NN) is proposed for such kind of optimization problems. The good approximation performance of neural network (NN) and the effective and robust evolutionary searching ability of genetic algorithm (GA) are applied in hybrid sense, where NNs are employed in predicting the objective value, and GA is adopted in searching optimal designs based on the predicted fitness values. Numerical simulation results and comparisons based on a well-known pressure vessel design problem demonstrate the feasibility and effectiveness of the framework, and much better results are achieved than some existed literature results.     

开发自创性实验的策略

为了优化教学行为,提高教学质量,有必要开发一些自创性实验.结合教学和实践经验,总结了开发自创性实验的10种策略.     

Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries

Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-molecule libraries.     

High‐Performance Magnetic Refrigerant Featuring One‐Dimensional Gd‐O Chains and O‐Gd3 Triangles

Magnetic cooling at low temperature has attracted intensive interest in cryogenics research, which may become important as cooling medium for long‐wave photon detectors to support space exploration. Here, we report a Gd‐based quaternary magnetic refrigerant material, Gd₅BSi₂O₁₃, containing chains of face‐shared GdO₉ polyhedra and geometrically frustrated OGd₃ triangles. Magnetic measurements indicate that Gd₅BSi₂O₁₃ exhibits a large magnetocaloric effect (MCE) about 1.74 times that of the practical magnetic refrigerant GGG (−ΔS_m=67.0 J kg⁻¹ K⁻¹). We analyzed the origin of the large MCE by comparing Gd^III‐containing compounds with different structures and concentrations of Gd^III.     

高三尖杉酯碱和三尖杉酯碱的合成研究

天然药物高三尖杉酯碱和三尖杉酯碱是从三尖杉植物的叶和茎中分离得到的微量生物碱,是手性化合物。结构上,二者不仅含有一个共同的母核三尖杉碱,酯基侧链的α位也均为手性叔醇。因母核三尖杉碱和酯基侧链较大的空间位阻,两个结构片段的酯化偶联具有较大的挑战性。设计合成位阻较小的侧链中间体是酯化反应发生的关键。因此,化学家们相继合成了结构多样的α-羰基羧酸侧链以及含有杂环的侧链中间体,如四元内酯杂环侧链、四氢呋喃杂环侧链、六氢吡喃杂环侧链、七元内酯杂环侧链,并成功地完成了高三尖杉酯碱、三尖杉酯碱和同属其他活性生物碱的合成。本文基于本课题组的相关研究,根据侧链片段的构建策略和方法,综述了天然药物高三尖杉酯碱、三尖杉酯碱以及其他天然产物的合成研究。不仅总结了近几年来的新进展,还对我国老一辈的科学家们在此方面作出的贡献进行了回顾。