On periodic solutions of nonlinear integral equations modelling infectious disease on measure chain

The modelling of the spread of infectious disease is carried out for time t on a measure chain T. Our approach unifies the continuous case and the discrete case . The model is described by the integral equation

where x(t) represents the proportion of the population infected at time t, f(t,x(t)) denotes the proportion of the population newly infected per unit time, and τ is the length of time an individual remains infectious. Using the measure chain calculus, we shall develop criteria for the existence of a nontrivial and nonnegative periodic solution for the modelling equation. The criteria can be implemented numerically, for this we shall give an algorithm as well as illustrative examples.     

单个心肌细胞内钙波的微观动力学研究

利用基于近场光学原理构建的全内反射荧光显微镜研究了大鼠单个心肌细胞中的钙信号. 利用这种显微镜的快速成像和高信噪比的特点，观察到单个细胞中复杂的二维钙波斑图. 分析了单个钙信号释放事件在钙波形成、运动过程中的作用. 建立在fire-diffuse-fire模型基础上的模拟显示，由基本钙释放事件组成的钙波可以在心肌细胞中稳定存在. 此研究对进一步认识活体可激发系统的微观动力学行为有指导意义. 关键词： 近场光学 全内反射荧光显微镜 心肌细胞 钙波     

锌与疾病关系的探讨

综述了锌与健康的关系，包括：锌的代谢，锌的主要功能，锌与疾病治疗等方面，参考文献16篇。     

Molecular Design and Immunogenicity of a Multiple-epitope FMDV Antigen and DNA Vaccination

This article reports the design and construction of a multiple-epitope foot and mouth disease virus （FMDV） antigen, designated as OAAT. This recombinant antigen consists of the structural protein VP1 genes from serotypes A and O FMDV, five major VP1 immunodominant epitopes from two genotypes of Asial serotype, and three Th2 epitopes originating from the nonstructural protein, three ABC gene and structural protein VP4 gene. Expressions of target gene from these plasmids in HeLa cells were verified by Western-blot. BALB/c mice were immunized intramuscularly with the DNA vaccines thrice every two weeks. We found that pA could induce simultaneously specific antibodies against serotypes A, Asial, and O FMDV. Compared to those of the controls, the spots of FMDV-specific IFN-7 and cytotoxic activity from mice immunized with pA were significantly increased, pA provided full protection in 2/4 guinea pigs from challenge with FMDV O/NY00 and Asial/YNBS/58, respectively. The results show that although pA did not give full protection in 100% immunized guinea pigs from challenge with type O and Asial FMDV, respectively, OAAT may be potential immunogen against FMDV and pA may be potential DNA vaccines against FMDV.     

地质环境中微量元素与人类心血管疾病

介绍了地质环境中三种微量元素硒，铜，钼的分布特点及与人类心血管疾病的关系。     

氧自由基与心血管疾病

随着氧自由基（ＯＦＲ）在疾病中的研究日趋深入，大量的资料证实氧自由基与充血性心力衰竭，动脉粥样硬化、心肌缺血、心律失常及淋巴细胞与心力衰竭的关系诸方面的发生，发匀有密切关系。     

Travelling wave fronts in a vector disease model with delay

In this paper, we study the diffusive vector disease model with delay. This problem with strong biological background has attracted much research attention. We focus on the existence of traveling wave fronts, and find that there is a moving zone for the transition from the disease-free state to the infective state. To complete the theoretical analysis, we employ the mathematical tools including the monotone iteration technique as well as the upper and lower solution method.