离子液体功能化二氧化硅催化Knoevenagel反应

在100 ℃, 无外加溶剂条件下, 离子液体功能化二氧化硅催化一系列芳醛和活泼亚甲基化合物进行Knoevenagel 缩合反应, 以高产率生成相应产物. 当反应底物为水杨醛与氰基乙酸乙酯的时候, 产物为3-乙氧基羰基香豆素, 这是水杨醛和氰基乙酸乙酯缩合关环, 再发生氰基醇解的产物. 采用离子液体功能化二氧化硅作为反应催化剂, 反应后催化剂可回收再利用.     

“树脂-捕获-释放”技术在有机合成中的应用

“树脂-捕获-释放”技术使用功能化聚合物清除剂选择性地吸附目标产物,液 相组合合成小分子化合物库。这一技术结合了固相和液相的优点,操作简便、快捷 ,反应容易控制,产物易分离,且产率高,纯度好。     

Morpholino‐Functionalized and Heteroaryl‐Substituted Titanocene Anti‐Cancer Drugs: Synthesis and Cytotoxicity Studies

From the carbolithiation of 6‐morpholino fulvene ( 3a ) and different ortho‐lithiated heterocycles (furan, thiophene and N‐methylpyrrole), the corresponding lithium cyclopentadienide intermediate ( 4a – c ) was formed. These three lithiated intermediates underwent a transmetallation reaction with TiCl₄ resulting in morpholino‐functionalised titanocenes 5a – c . When these titanocenes were tested against LLC‐PK cells, the IC₅₀ values obtained were of 58, 63 and 115 μM for titanocenes 5a – c respectively. The most cytotoxic titanocene 5a with an IC₅₀ value of 58 μM is found to be approximately 20 times less cytotoxic than cis‐platin, which showed an IC₅₀ value of 3.3 μM, when tested on the LLC‐PK cell line, and 10 times less cytotoxic than its dimethylamino‐functionalised analogue (Titanocene C , IC₅₀ = 5.5 μM).     

苯并噻唑功能化的金属螯合剂的合成及生物活性

设计、合成了2种苯并噻唑功能化的金属螯合剂:N,N′-双(水杨醛)缩-2,2′-(3-(苯并[d]噻唑-2-基)-1,2-苯基)二氧乙基二胺L1和N,N′-双(水杨醛)缩-2,2′-(4-(苯并[d]噻唑-2-基)-1,2-苯基)二氧乙基二胺L2。并通过比浊度分析、BCA实验、HRP/Amplex Red实验以及MTT实验检测它们的生物活性。发现这2种螯合剂都能有效抑制金属离子(Zn~(2+)、Cu~(2+))诱导的Aβ_(1～40)的聚集,能大幅减少Cu-Aβ加合物产生H_2O_2的量,有效抑制Zn~(2+)、Cu~(2+)诱导Aβ聚集而产生的神经细胞毒性,并大幅提高细胞存活率。作为比较,对非苯并噻唑功能化但螯合部位相同的螯合剂做了相同的生物活性测试,但其生物活性明显比苯并噻唑功能化的金属螯合剂的低。     

官能团化聚丙烯对Mg(OH)2/PP结晶与熔融行为的影响

制备了官能团化聚丙烯改性Mg(OH)2/PP复合材料，并用DSC研究了改性PP，Mg(OH)2/PP和改性Mg/(OH)2/PP中PP的结晶与熔融行为，官能团化PP（FPP），丙烯酸（AA）和Mg(OH)2都能提高PP的结晶温度，归结于异相成核作用，AA和FPP加入进一步使Mg(OH)/PP中PP结晶温度提高，但AA用量增加对PP结晶温度无影响。     

Mucin Interactions with Functionalized Polystyrene Latexes

The interactions of pig gastric mucin and bovine submaxillary mucin with carboxylate (PCM) and amino (PAM) polystyrene latexes with 750 and 1000 nm diameters have been studied in vitro. The mucin interaction increased when the pH decreased from 7.4 to 3.0 and when the electrolyte concentration increased from 86 to 205 mM. The driving force of the interaction was very probably nonionic. Under certain conditions, electrostatic attraction also was important for PAM. Under all experimental conditions tested, the mucins interacted less with PAM than with PCM. The functional groups of the latexes directed the conformation of the adsorbed mucins at the interface. At low pH, the mucins probably were adsorbed in multilayers.     

Biological activity of functionalized SiO2 thin films prepared by sol-gel method

In this work we investigated the biological properties of sol-gel films in aqueous medium. Functionalized silica films were prepared by the sol-gel process, from organically modified silicon alkoxides with amino or thiol groups. Covalent binding of proteins with different orientations according to the hydrophilic or hydrophobic character of the surface was studied. This binding occurred via a covalent coupling agent providing a very stable linkage. No denaturation was detected and a good detection of the antigen was observed. Immunoassays have demonstrated the biological activity of grafted antibodies.     

Displacement of adsorbed functionalized polystyrene-block-butadiene copolymers by small molecules

This work deals with the displacement of end-anchored copolymers by the addition of solvent displacer. The adsorption behavior of functionalized polystyrene-block-polybutadiene diblock copolymers from dilute solution in toluene using silicon wafers as solid substrates is investigated by means of null-ellipsometry. The desorption phenomena are observed by adding displacers of low molecular weight to the mixture. The displacers used are tetrahydrofuran (THF) and acetone. The critical composition of the binary solvent mixture at which the desorption is complete, is determined experimentally.     

Fabrication of ultra‐small ruthenium nanoparticles on porous modified reduced graphene oxide and its application in solvent‐free oxidation of cyclohexene with molecular oxygen

In the present work, ruthenium nanoparticles were synthesized on functionalized reduced graphene oxide (rGO). First, the surface of rGO was modified with two para‐arsanilic acid and dithiooxamide promoters to create the rGO with scattered hydrophilic positions. The ruthenium nanoparticles were synthesized and immobilized simultaneously in small hydrophilic micro‐reactors under mild conditions. Characterization of the synthesized nanocatalyst was confirmed with different techniques, such as transmission electron microscopy (TEM), X‐ray diffraction, Fourier transform‐infrared and scanning electron microscopy. TEM images of the synthesized catalyst show the Ru nanoparticles have diameters less than 6 nm. The designed nanocatalyst was investigated for the selective liquid phase oxidation of cyclohexene with molecular oxygen in an autoclave under solvent‐free conditions, which obtained a maximum of 91% conversion and 90% selectivity under optimized conditions. The catalytic activity over rGO‐AO‐TO/Ru recycled catalyst remained at a satisfactory state after at least five runs.     

Polymorphism of nylon-6 in nylon-6/nanoclay/functionalized polyolefin blends

The crystallization behavior of Nylon-6 and the interaction in Nylon-6/nanoclay/functionalized polyolefin blends were investigated by X-ray diffraction and Fourier transform infrared spectroscopy. For samples without any thermal history, the interaction between Nylon-6 and nanoclay or the interaction between Nylon-6 and functionalized polyolefin favors the formation of γ form crystal. In contrast, the presence of both nanoclay and functionalized polyolefin together in Nylon-6 was found to have an antagonistic effect on each other's ability to promote the formation of γ form crystal. This was attributed to the complex interactions between the constituents. The crystallization behavior of Nylon-6 in Nylon-6/nanoclay/functionalized polyolefin blends is clearly affected by the cointeraction of these effects. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 1494–1502, 2007