磁性靶向药物递送中铁磁流体的动力学建模

Among the proposed techniques for delivering drugs to specific locations within human body, magnetic drug targeting prevails due to its non-invasive character and its high targeting efficiency. Magnetic targeting drug delivery is a method of carrying drug-loaded magnetic nanoparticles to a target tissue target under the applied magnetic field. This method increases the drug concentration in the target while reducing the adverse side-effects. Although there have been some theoretical analyses for magnetic drug targeting, very few researchers have addressed the hydrodynamic models of magnetic fluids in the blood vessel. A mathematical model is presented to describe the hydrodynamics of ferrofiuids as drug carriers flowing in a blood vessel under the applied magnetic field. In this model, magnetic force and asymmetrical force are added, and an angular momentum equation of magnetic nanoparticles in the applied magnetic field is modeled. Engineering approximations are achieved by retaining the physically most significant items in the model due to the mathematical complexity of the motion equations. Numerical simulations are performed to obtain better insight into the theoretical model with computational fluid dynamics. Simulation results demonstrate the important parameters leading to adequate drug delivery to the target site depending on the magnetic field intensity, which coincident with those of animal experiments. Results of the analysis provide important information and suggest strategies for improving delivery in clinical application.     

Numerical Simulation of Ferrofluid Flow for Subsurface Environmental Engineering Applications

Ferrofluids are suspensions of magnetic particles of diameter approximately 10nm stabilized by surfactants in carrier liquids. The large magnetic susceptibility of ferrofluids allows the mobilization of ferrofluid through permeable rock and soil by the application of strong external magnetic fields. We have developed simulation capabilities for both miscible and immiscible conceptualizations of ferrofluid flow through porous media in response to magnetic forces arising from the magnetic field of a rectangular permanent magnet. The flow of ferrofluid is caused by the magnetization of the particles and their attraction toward a magnet, regardless of the orientation of the magnet. The steps involved in calculating the flow of ferrofluid are (1) calculation of the external magnetic field, (2) calculation of the gradient of the external magnetic field, (3) calculation of the magnetization of the ferrofluid, and (4) assembly of the magnetic body force term and addition of this term to the standard pressure gradient and gravity force terms. We compare numerical simulations to laboratory measurements of the magnetic field, fluid pressures, and the twodimensional flow of ferrofluid to demonstrate the applicability of the methods coded in the numerical simulators. We present an example of the use of the simulator for a fieldscale application of ferrofluids for barrier verification.     

Total-reflection X-ray fluorescence: An alternative tool for the analysis of magnetic ferrofluids

This work presents the first application of the total-reflection X-ray fluorescence (TXRF) to the compositional study of magnetic ferrofluids. With the aims of validating the best analytical conditions and also, limitations of the TXRF in the compositional study of these materials, an alternative empirical method, based in the use of angle-dependence TXRF (AD-TXRF) measurements, is proposed. Three kinds of ferromagnetic nanoparticles, with different morphologies, have been studied. The techniques of inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectroscopy (ICP-OES) have been used to validate the TXRF results. In contrast with the plasma techniques, the developed TXRF procedure need not of previous chemical acid digestion. Additionally, two procedures of magnetic nanoparticles synthesis, co-precipitation and laser-pyrolysis, have been checked for the contaminants trace metals Zn, Mn and Cr. It has been found that the method of laser-pyrolysis produces nanoparticles of higher purity.     

Synthesis, surface modifications, and size-sorting of mixed nickel-zinc ferrite colloidal magnetic nanoparticles

We report on the spontaneous covalent growth of monomolecular adlayers on mixed nickel-zinc nanoferrite colloidal suspensions (ferrofluids). Synthesized nanoparticles were subjected to surface modification by means of acid chloride chemistry, leading to the formation of covalent bonds between the hydroxy groups at the nanoparticle surface and the acid chloride molecules. This procedure can be easily tailored to allow for the formation of adlayers containing both hydrophobic and hydrophilic regions stacked at predetermined distances from the magnetic core, and also providing the nanoferrites with functional carboxy groups capable of further modifications with, for example, drug molecules. Here, fluorophore aminopyrene molecules were bound to such modified nanoferrites through amide bonds. We also used the same chemistry to modify the surface with covalently bound long-chain palmitoyl moieties, and for comparison we also modified the nanoferrite surface by simple adsorption of oleic acid. Both procedures made the surface highly hydrophobic. These hydrophobic colloids were subsequently spread on an aqueous surface to form Langmuir monolayers with different characteristics. Moreover, since uniformity of size is crucial in a number of applications, we propose an efficient way of sorting the magnetic nanoparticles by size in their colloidal suspension. The suspension is centrifuged at increasing rotational speed and the fractions are collected after each run. The mean size of nanoferrite in each fraction was measured by the powder X-ray diffraction (PXRD) technique.     

Preparation of Dy‐ferrite Ferrofluids and Magnetochemical Studies on the Superparamagnetism

This paper reports unprecedented preparation of Dy‐ferrite water‐based ferrofluids stabilized by polymeric surfactant PMAA. The stability of ferrofluids was characterized in terms of the equation of criterion for the stability of ferrofluids. Magnetic susceptibility was measured with a Faraday‐type magnetic balance at different temperature and with different magnetic field intensity. According to the Langevin function, superparamagnetism of Dy‐ferrite ferrofluids has been confirmed by the curves of saturation magnetization σ versus H/ T, and the blocking temperature is between 160 and 200 K. In terms of the simplified Langevin function in the low magnetic field, the average particle size is 20 nm that coincides with the result evaluated by FHMW. In addition, chemical analysis, infrared spectra and Mossbauer spectroscopy were utilized to analyze the main components of the ferrofluids.     

Berezinskii–Kosterlitz–Thouless Order in Two-Dimensional O(2)-Ferrofluid

We study a two-dimensional ferrofluid of hard-core particles with internal degrees of freedom (plane rotators) and O(2)-invariant ferromagnetic spin interaction. By reducing the continuous system to an approximating reference lattice system, a lower bound for the two-spin correlation function is obtained. This bound, together with the Fröhlich–Spencer result about the Berezinskii–Kosterlitz–Thouless transition in the two-dimension lattice system of plane rotators, shows that our model also exhibits the same kind of ordering. Namely for a short-range ferromagnetic interaction the two-spin correlation function does not decay faster than some power of the inverse distance between particles, for small temperatures and high densities of the ferrofluid. For a long-range ferromagnetic interaction the model manifests a non-zero order parameter (magnetization) in this domain, whereas for high temperatures spin correlations decay exponentially.     

All-optical modulator based on a ferrofluid core metal cladding waveguide chip

We propose a novel optical intensity modulator based on the combination of a symmetrical metal cladding optical waveguide （SMCW） and ferrofluid, where the ferrofluid is sealed in the waveguide to act as a guiding layer. The light matter interaction in the ferrofluid film leads to the formation of a regular nanoparticle pattern, which changes the phase match condition of the ultrahigh order modes in return. When two lasers are incident on the same spot of the waveguide chip, experiments illustrate all-optical modulation of one laser beam by adjusting the intensity of the other laser. A possible theoretical explanation may be due to the optical trapping and Soret effect since the phenomenon is considerable only when the control laser is effectively coupled into the waveguide.     

垂直圆管氮气-磁性液体两相流电磁感应现象

基于磁性液体与非磁性气泡磁导率的差异,理论分析与实验研究了氮气-磁性液体两相流的电磁感应现象。以颗粒体积浓度为3.83%的水基Fe₃O₄磁性液体为工质,同时采用物性与其相近的去离子水进行流型的可视化对比研究。研究结果表明,当管内为泡状流、弹状流、搅拌流时均能产生毫伏级的感应电压,且感应电压的峰峰值随着气体流量的增加而增大,另外根据感应电压随时间变化的波形可以辨识出管内的流型。     

Hydrodynamic modelling and CFD simulation of ferrofluids flow in magnetic targeting drug delivery

Magnetic targeting drug delivery is a method of carrying drug-loaded magnetic nanoparticles to a tissue target in the human body under the applied magnetic field. This method increases the drug concentration in the target and reduces the adverse side-effects. In this article, a mathematical model is presented to describe the hydrodynamics of ferrofluids as drug carriers flowing in a blood vessel under the applied magnetic field. Numerical simulations are performed to obtain better insight into the theoretical analysis with computational fluid dynamics. A 3D flow field of magnetic particles in an idealised blood vessel model containing an aneurysm is analysed to further understand clinical application of magnetic targeting drug delivery. Simulation samples demonstrate the important parameters leading to adequate drug delivery to the target site depending on the applied magnetic field in coincidence with reported results from animal experiments. Results of the analysis provide the important information and can suggest strategies for improving delivery in favour of the clinical application.     

通过磁光效应研究磁性液体在外场下的颗粒成链现象

在对磁性液体的磁光效应的理论分析与实验测量的基础上讨论了其在磁场下的各向异性现象.首先,通过电磁理论对成链的各向异性介质模型的介电张量形式进行了一般性的分析,然后,基于磁性液体的微观理论模型讨论了磁性液体在外加磁场下出现凝聚成链的行为.基于上面的结果,我们将实验可观测量——两种传输模式的折射率差和不同颗粒数的链(长度不同的链)的比例以及磁场强度建立联系.最后,在实验上探测了磁性液体薄膜的透射光偏振状态变化随外磁场的变化,并对测得的数据进行计算机拟合分析,验证了不同长度的链的数目之间的比例关系.