Quality evaluation of fingerprints of herbal medicine with chromatographic data

In this study, local least squares (LLS) and principal component analysis (PCA) were applied to deal with the disturbances in a data set of chromatographic fingerprints after necessary data transformations. It has been demonstrated that PCA with standard normal variate (SNV) transformation of data led to meaningful classification of 33 different Erigeron breviscapus herbal samples. The result was also corroborated by variance squares discriminant method. The quality of herbal objects was further evaluated, and the causes of this fact have been explained from a chemical point of view. At the same time, it implied an idea for qualitative evaluation of the herbal objects with a common class pattern of chromatographic fingerprints.     

硫酸颜色反应用于荧光法测定利血平研究

提出了硫酸颜色反应用于利血平的荧光分析新方法。利用血平与浓硫酸反应，生成强荧光物质，所得产物的荧光强度与利血平的浓度在０－０．６μｇ／ｍＬ范围内有良好的线性关系。检测限为０．２ｎｇ／ｍＬ。本法可直接用于尿液中利血平的定量分析，回收率为８２．５％－８４．２％。     

A non-catalytic approach to the synthesis of 5,6-dihydrobenzo[h]quinolines

A concise synthesis of highly functionalized 5,6-dihydrobenzo[h]quinoline-3-carbonitriles is delineated through base induced ring transformation of 4-sec-amino-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitriles with S-methylisothiourea sulfate and 1-carboxamidinepyrazole hydrochloride, separately, in DMF. Under analogous reaction conditions the ring transformation of 4-sec-amino-2-oxo-5,6-dihydro-2H-benzo[h]chromene-3-carbonitriles by formamidine acetate provided 4-sec-amino-benzo[h]quinoline-3-carbonitriles in moderate yields, while with benzamidine hydrochloride, the reaction followed the same mechanism to yield 2-phenyl-4-sec-amino-5,6-dihydrobenzo[h]quinoline-3-carbonitriles.     

An unusual synthesis of tetrahydrobenzo[f]isoquinolines

A facile and short synthesis of 2-oxo-4-sec-amino-2,3,5,6-tetrahydrobenzo[f]isoquinoline-1-carbonitriles has been delineated through base catalyzed ring transformation of 5,6-dihydro-2-oxo-4-sec-amino-2H-benzo[h]chromene-3-carbonitrile by cyanoacetamide in excellent yields.     

Solid-state synthesis, structural variants and transformation of three-dimensional sulfides, AGaSnS4 (A=Na, K, Rb, Cs, Tl) and Na1.263Ga1.263Sn0.737S4

New cubic-AGaSnS₄ (A=Na, K, Rb, Cs, Tl) and orthorhombic-NaGaSnS₄ compounds were synthesized by solid-state reactions and characterized by X-ray diffraction and diffuse reflectance spectroscopy. Single crystals of orthorhombic-Na_1.263Ga_1.263Sn_0.737S₄ were obtained in the crystal growth attempts of sodium compound. All six new compounds have orthorhombic AgGaGeS₄ and cubic BaGa₂S₄ structures, as determined from single crystal X-ray structures of Na_1.263Ga_1.263Sn_0.737S₄ and cubic-AGaSnS₄ (A=Na, K, Rb). Orthorhombic-NaGaSnS₄ and known layered-KGaSnS₄ undergo structural transformation to thermodynamically stable cubic form.     

Reversible Full‐Range Color Control of a Cholesteric Liquid‐Crystalline Film by using a Molecular Motor

By using a chiral molecular motor as a dopant in a cholesteric liquid‐crystalline film, fully reversible control of the reflection color of this film across the entire visible spectrum is possible. The large difference in helical twisting power between the two isomeric forms of the motor allows efficient light‐ and heat‐induced switching of the helicity of the cholesteric liquid‐crystal superstructure.     

老年人彩度对比敏感度函数研究及滤波应用

为研究老年人彩色视觉频率响应特性，获取彩度对比敏感度与空间频率之间的函数关系，本文在LCH均匀颜色空间基础上，固定明度和色调角值，以彩度作为变量，设计人眼彩度对比敏感度实验，进行人眼视觉观察实验。获得彩度对比敏感度与空间频率的关系，并构建指数型对比敏感度函数模型。经分析表明老年人眼彩度对比敏感度随着空间频率的增加，产生先升高再缓慢降低的变化，各色调角下彩度对比度存在差异。经分析人眼对比敏感度差异与人眼视觉辨色特性有很大的相关性。并且，将构建的对比敏感度函数模型用于实现基于人眼视觉系统的滤波处理。     

In vitro TRANSFORMATION OF RAT ESOPHAGEAL EPITHELIAL CELLS BY FUSARIN C

Fusarin C (FC) is a mutagenic and carcinogenic mycotoxin which was isolated from Fu-sarium moniliforme culture extracts. The Fusarium moniliforme is one of most prevalent fungi found on corn in Linxian, a high risk area for esophageal cancer. This paper reports, for the first time, the malignant transformation of rat esophageal epithelial cells induced by FC. The transformed cells showed several characteristics of transformation. Colonies were formed after seeding these transformed cells either into selective medium free of epidermal growth factor (EGF) and serum, or on semi-solid agar; there was an increase in chromosome number; the expression of c-myc and v-erb-B oncogenes was enhanced in the cells; and squamous cell carcinomas arose after inoculating the cells into nude mice. The results demonstrated transforming effect of FC on rat esophageal epithelial cells, and indicate that the abnormal expression of some oncogenes could serve as a hew property of transformed cells.