We describe a selective and mild chemical approach for controlling RNA hybridization, folding, and enzyme interactions. Reaction of RNAs in aqueous buffer with an azide‐substituted acylating agent (100–200 mm ) yields several 2′‐OH acylations per RNA strand in as little as 10 min. This poly‐acylated (“cloaked”) RNA is strongly blocked from hybridization with complementary nucleic acids, from cleavage by RNA‐processing enzymes, and from folding into active aptamer structures. Importantly, treatment with a water‐soluble phosphine triggers a Staudinger reduction of the azide groups, resulting in spontaneous loss of acyl groups (“uncloaking”). This fully restores RNA folding and biochemical activity. 相似文献
The aim of this work is to derive sharp quantitative estimates of the qualitative convergence results developed by Li et al. (2015) for regularized full- and partial-cloaks through transformation optics approach. Let Γ0 be a compact set in ?3 and Γδ be a δ-neighborhood of Γ0 for δ∈?+. Γδ represents the virtual domain used for the blow-up construction. By incorporating suitably designed lossy layers, it is shown that if the generating set Γ0 is a generic curve, then one would have an approximate full-cloak within δ2 to the perfect full-cloak, whereas if Γ0 is the closure of an open subset on a flat surface, then one would have an approximate partial-cloak within δ to its perfect counterpart. The estimates derived are independent of the contents being cloaked; that is, the cloaking devices are capable of nearly cloaking an arbitrary content. Furthermore, as a significant by-product, our argument allows the relaxation of the convexity requirement on Γ0 by Li et al. (2015), which is critical for the Mosco convergence argument therein. 相似文献
A major aim of researchers working in the field of optics and photonics is to mold the flow of light in optical structures and devices. In the regime of ballistic light propagation, transformation optics has given a certain boost, for which optical invisibility cloaking devices are striking examples. Our capability to mold the flow of light in the regime of diffuse light propagation in light‐scattering media has fallen behind—while diffuse light from clouds, white wallpaper, computer monitors, and light‐emitting diodes is literally all around us every day. In this review, we summarize progress in steering the flow of diffuse light in turbid media which was triggered by the mathematical analogy between electrostatics, magnetostatics, stationary heat conduction, and stationary light diffusion. We give an extensive tutorial introduction to the mathematics of the diffusion equation for light and its solutions, present an overview on the current experimental state‐of‐the‐art of simple core–shell invisibility cloaking, and compare these experiments with diffusion theory as well as with more advanced modelling based on Monte Carlo simulations. The latter approach enables spanning the bridge from diffusive to ballistic light propagation.
Metamaterials are artificial composite materials engineered to have properties that may not be found in nature. By exploring locally resonant effect of the building units, elastic metamaterials are able to possess negative values of effective mass, effective bulk or shear modulus. Mass-spring and continuum material versions of these elastic metamaterials are reported and the physical mechanisms of negative effective parameters are demonstrated. Applications of metamaterials to acoustic cloaking and superlensing are also discussed. 相似文献
Transformational acoustics offers the theoretical possibility of cloaking obstacles within fluids, provided metamaterials having continuously varying bulk moduli and densities can be found or constructed. Realistically, materials with the proper, continuously varying anisotropies do not presently exist. Discretely layered cloaks having constant material parameters within each layer are a viable alternative, but due to their discrete nature, may become ineffective outside of narrow frequency ranges. Because of such limitations, there is interest in finding discretely layered systems that can be effective in as wide as possible bandwidth without the need for unrealizable material properties within each layer. The present work introduces a novel methodology for finding optimal material parameters for use in such layered cloaks. In principle, the technique could be applied to any acoustic or electromagnetic scattering problem, but for purposes of demonstration, this paper considers a fluid-loaded acoustically hard sphere with a cloak that comprised layered pentamodes, whose material properties are constrained to lie within reasonable ranges relative to the density and bulk modulus of water. 相似文献