纤维素2,3-位和2,3,6-位苯基氨基甲酸酯手性固定相的选择性研究

合成了纤维素-2,3,6-三苯基氨基甲酸酯、纤维素-2,3-二苯基氨基甲酸酯、纤维素-2,3,6-三(3,5-二甲基苯基氨基甲酸酯)和纤维素-2,3-二(3,5-二甲基苯基氨基甲酸酯)4种纤维素衍生物手性固定相,用正己烷-异丙醇（体积比为9∶1）混合液作流动相,对9种手性化合物进行了高效液相色谱拆分。实验结果表明:对所测的9个样品,纤维素-2,3-二苯基氨基甲酸酯的手性选择性大大好于纤维素-2,3,6-三苯基氨基甲酸酯;而纤维素-2,3-二(3,5-二甲基苯基氨基甲酸酯)与纤维素-2,3,6-三(3,5-二甲基苯基氨基甲酸酯)的分离因子针对不同的对映体各有优点,但前者通常具有更小的保留因子,可以缩短一定的分析时间。     

聚合反应制备键合型纤维素-三(4-甲基苯基甲酸酯)衍生物类手性固定相

合成了带有甲基丙烯酰基的纤维素-三(4-甲基苯基甲酸酯)衍生物(CTMB),并通过聚合反应将其键合在具有双键的硅胶表面,得到手性固定相(CSP)。用所得到的CSP对9种对映体化合物(丁苯酞、酮基布洛芬、反-2,3-二苯环氧乙烷、安息香、安息香类似物、托葛尔碱、华法令、4,4′-二甲氧基-5,6,5′,6′-二次甲二氧基-2,2′-羰甲基甲酯联苯、4,4′-二甲氧基-5,6,5′,6′-二次甲二氧基-2-羰甲基甲酯-2′-羰甲基乙酯联苯)进行了拆分。考察了CSP制备过程中甲基丙烯酰氯的用量、键合方式以及硅胶     

流动相组成对外消旋阿苯达唑亚砜对映体拆分的影响

涂敷直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)(ADMPC)于自制的球形氨丙基硅胶上,制备了一种手性固定相。采用高效液相色谱法(HPLC),在正相条件下用该固定相直接拆分了广谱驱虫药物阿苯达唑的代谢产物阿苯达唑亚砜(albendazole sulfoxide, ABZSO)的外消旋对映体。系统地选用了多种二元及三元流动相体系对样品进行拆分,结果表明,流动相中不同种类的醇改性剂及其含量的不同对样品的保留时间和立体选择性有不同程度的影响,甲醇、乙醇等作改性剂用于拆分样品的效果较好;采用三元流动相体系正己烷-     

手性催化剂(4R)-苄氧基-(S)-脯氨酸的合成及其对不对称羟醛反应的催化活性

手性催化剂(4R)-苄氧基-(S)-脯氨酸的合成及其对不对称羟醛反应的催化活性;羟醛反应     

Equation of State of Nuclear Matter in Chiral σ-ω Model

The equation of state of nuclear matter is studied in the 1-loop approximation of chiral linear σ-ω model. By introducing the density-dependent coupling constants, the problem of tachyon pole in the chiral σ-ω model is resolved. The 1-loop contributions of σ and π mesons to the nucleon's binding energy are included, while the empirical properties of nuclear matter such as saturation density, binding energy, and incompressibility are well reproduced.     

Dispersion Relation of σ Meson and Pion at Finite Nuclear Density in Chiral σ Model

The propagators of pion and sigma meson at a finite nuclear density and zero temperature are studied in chiral σ model. Their dispersion relations are calculated numerically in one-loop approximation. In order to avoid the so-called tachyon pole appearing in the one-loop propagators of pion and sigma meson, we regard the mass of sigma meson m_σ as a free parameter and adjust it to fit the nuclear saturation properties. For m_σ equal to 3075 MeV, the tachyon pole does not appear at the normal nuclear density. Thus the dispersion relation can be calculated in chiral σ model in one-loop level for the first time.     

液相色谱手性固定相法直接拆分外消旋金属簇合物

在自制的涂敷型纤维素-三(3,5-二甲基苯基氨基甲酸酯)手性固定相上直接拆分了新近合成的外消旋四面体金属簇合物,得到了满意的色谱分离结果,为进一步实现色谱制备具有旋光活性的金属簇合物提供了基础条件。同时还考察了温度及流动相中的极性改性剂醇的种类及结构对手性拆分的影响。结果发现,醇的立体结构 极性对簇合物的手性拆分均有影响。在相同的色谱条件下,用正构醇作极性改性剂对该金属簇合物的拆分效果比用异丙醇好。     

手性铝催化剂在不对称合成中的应用

综述了手性铝催化剂在不对称Diels-Alder、Michael加成、1, 3-偶极环加成、Ene反应、磷氢化、氰硅化、烯丙基化、氢化、Claisen重排、Friedel-Crafts烷基化、Aldol等反应中的应用.     

Non-commutative Chiral QCD2 Model

The effective action of chiral QCD₂ was studied in two-dimensional non-commutative space-time by using path integral approach. It is shown that vector boson has a mass generation and the effective Lagrangian contains a term corresponding to a Wess-Zumino-Witten-like term.     

Structures of（ΩΩ）0＋and（[1]Ω）1＋in Extended Chiral SU（3） Quark Model

The structures of (ΩΩ)0 and ([1]Ω)1 are studied in the extended chiral SU(3) quark model in which vector meson exchanges are included. The effect from the vector meson fields is very similar to that from the one-gluon exchange (OGE) interaction. Both in the chiral SU(3) quark model and in the extended chiral SU(3) quark model,di-omega (ΩΩ)0 is always deeply bound, with over one hundred MeV binding energy, and ([1]Ω)1 ‘s binding energy is around 20 MeV. An analysis shows that the quark exchange effect plays a very important role for making di-omega (ΩΩ)0 deeply bound.