Comparative Study of the Enantioseparation of Uniconazole and Imazalil by HPLC on Various Cellulose Chiral Columns

Abstract

This paper reported the enantioseparation of uniconazole and imazalil using four different self‐prepared cellulose derivative columns, namely, CTB, CTMB, CTPC, and CDMPC. The mobile phase composition including the type of the alcohol modifier and the ethanol concentration in hexane changed, and the influence on the retention factor (k′); for each enantiomer, the separation factor (α) and the resolution (R_S) was studied. The influence of the structures of the analytes on the chiral separation was investigated. The results showed that uniconazole obtained the best resolution of 2.16 on CTPC, while imazalil obtained the best separation on CTMB, with the maximal resolution of 4.83. It was concluded that the structure of solutes and CSP play a key role in the chiral recognition. And the chiral attraction between them is the predominant factor.     

手性流动相添加法拆分酮康唑外消旋体

采用C18反相色谱柱,利用在流动相中加入手性选择剂的方法实现酮康唑对映体的拆分。研究了手性选择剂的种类及浓度、流动相pH值、甲醇比例和柱温等因素对酮康唑手性分离的影响,结果表明磺丁基-β-环糊精可以使酮康唑对映体完全分离,最后选择的流动相组成为甲醇-0.02 mol/L磷酸二氢钠(体积比为60∶40,含0.02%三乙胺和1.0 mmol/L磺丁基-β-环糊精,用稀磷酸调节pH值到3.00)。酮康唑对映体在6 min内得到基线分离,分离度为2.05。方法简便,分离效果好,对酮康唑对映体的拆分具有应用价值。     

Acoustic stop bands in almost-periodic and weakly randomized stratified media： perturbation analysis

In this paper, we analyze the effect of both deter- ministic and random perturbations of a regular multi-layered elastic structure on its stop band properties. The tool of choice is the transfer matrix method, which is both versatile and easy to implement. In both cases, we find that the stop-bands widen. We observe the appearance of very narrow pass-bands within the stop-bands, which can be observed in other instances in optics.     

New Terms for Compact Form of Electroweak Chiral Lagrangian

The compact form of the electroweak chiral Lagrangian is a reformulation of its original form and is expressed in terms of chiral rotated electroweak gauge fields, which is crucial for relating the information of underlying theories to the coefficients of the low-energy effective Lagrangian. However the compact form obtained in previous works is not complete. In this letter we add several new chiral invariant terms to it and discuss the contributions of these terms to the original electroweak chiral Lagrangian.     

Unconventional Energy Bands and Chirality of Ultracold Atoms in Trilayer Honeycomb Lattice

We investigate ultracold fermionic atoms in the trilayer honeycomb lattice. In the low energy approximation, we derive an effective Hamiltonian for pseudospins. The energy spectrum shows a cubic form of the wavevector and is gapless. The quasiparticles and quasiholes are chiral and show Berry's phase π when thewavevector adiabatically evolves along a closed circle. Furthermore, the experimental detection of the energy spectrum is proposed with Bragg scattering techniques.     

高效液相色谱手性固定相法拆分阿折地平对映体

建立了阿折地平对映体的高效液相色谱拆分方法。采用Chiralpak AD-H (250 mm×4.6 mm, 5.0 μm, Daicel公司)手性色谱柱在正相条件下直接拆分阿折地平对映体,考察了固定相种类、流动相组成及柱温等对阿折地平对映体分离的影响。确定了最佳的拆分条件: 流动相为正己烷-异丙醇(90:10, v/v),流速为0.8 mL/min,检测波长为254 nm;柱温为20 ℃;在此条件下阿折地平对映体的分离度为3.3。该法简单快速,重现性好。     

手性高效液相色谱法测定板蓝根中表告依春和告依春含量

采用Chiralpak IC手性柱(250 mm×4.6 mm, 5 μm),建立了正相高效液相色谱测定板蓝根中表告依春(R-告依春)和告依春(S-告依春)含量的方法。考察了流动相组成、流速和柱温对分离度的影响。经优化后的实验条件: 以正己烷-异丙醇(体积比为90:10)为流动相,流速为0.8 mL/min;检测波长为245 nm,柱温为20 ℃。在此优化条件下,表告依春和告依春分离度为3.4,检出限为2.0 mg/L,在0.02～2.0 g/L范围内有良好的线性关系,平均回收率为101%,相对标准偏差(RSD)小于3.0%(n=6)。本方法可将具有抗病毒活性的表告依春与其对映体告依春基线分离并测定,专属性强,能有效控制板蓝根的质量。     

Study of Radiative Decays Ds1(2536) → Ds(1968)+γ andDs1(2536) → Ds*(2112)+γ in CQM Model

There are some uncertain characteristics of the D_s1(2536), which deserves further discussion. Based on the assumption that the meson is constituted by c\bar{s}, and belongs to T doublet (1⁺,2⁺), radiative decays D_s1(2536)→D_s(1968)+γ and D_s1(2536)→ D_s*(2112)+γ are studied in the CQM model. The large branching ratios of them from our calculations not only indicate the process may be detected in the future experiments, but also can give a deep comprehension of the structure of it.     

Derivation of the Bosonic Part of the Electroweak Chiral Lagrangian from a General Underlying Technicolor Theory

Bosonic part of SU(2)_L\otimes U(1)_Y effective chiral Lagrangian for electroweak symmetry breaking is derived from an underlying technicolor theory with no approximation. The underlying theory is assumed to be the most general gauge theory without fundamental scalars. A condensate is required to exist in the theory which breaks SU(2)_L\otimes U(1)_Y dynamically to U(1)_em and the anomaly of the theory caused by gauge interaction must be cancelled. The formulation offers general definitions in terms of underlying theory for the low energy constants in effective chiral Lagrangian.     

Nuclear Matter in a Chiral SU(3) Quark Mean-Field Model

A quark meson coupling model based on SU(3)_L×SU(3)_R symmetry and scale invariance is proposed. The quarks and mesons get masses through symmetry broken. We apply this SU(3) chiral constituent quark model to investigating the nuclear matter at finite temperature and density. The effective baryon masses, compression modulus and hyperon potentials are all reasonable. The critical temperature of liquid-gas phase transition is also calculated in this model.