GLOBAL ATTRACTOR FOR A DENSITY-DEPENDENT SENSITIVITY CHEMOTAXIS MODEL

In this paper, a chemotaxis model with reproduction term in a bounded domain R n is discussed. The existence of a global-in-time solution and a global attractor for this model are obtained.     

Global attractor for a density-dependent sensitivity chemotaxis model

In this paper, a chemotaxi model with reproduction term in a bounded domain Ω ⊂ Rⁿ is discussed. The existence of a global-in-time solution and a global attractor for this model are obtained.     

The use of a generalized born model for the analysis of protein conformational transitions: a comparative study with explicit solvent simulations for chemotaxis Y protein (CheY)

To investigate whether implicit solvent models are appropriate for mechanistic studies of conformational transition in proteins, a recently developed generalized Born model (GBSW) was applied to a small signaling protein, chemotaxis protein Y (CheY), with different combinations of the phosphorylation state and conformation of the system; the results were compared to explicit solvent simulations using a stochastic boundary condition. The subtle but distinct conformational transitions involved in CheY activation makes the system ideally suited for comparing implicit and explicit solvent models because these conformational transitions are potentially accessible in both types of simulations. The structural and dynamical properties analyzed include not only those localized to the active site region but also throughout the protein, such as sidechain methyl group order parameters, backbone hydrogen bonding lifetime and occupancy as well as principal components of the trajectories. Overall, many properties were well reproduced by the GBSW simulations when compared with the explicit solvent calculations, although a number of observations consistently point to the suggestion that the current parameterization of the GBSW model tends to overestimate hydrogen-bonding interactions involving both charged groups and (charge-neutral) backbone atoms. This deficiency led to overstabilization of certain secondary structural motifs and more importantly, qualitatively different behaviors for the active site groups (Thr 87, Ala 88, the beta4-alpha4 loop) in response to phosphorylation, when compared with explicit solvent simulations. The current study highlights the value of carrying out both explicit and implicit solvent simulations for complementary mechanistic insights in the analysis of conformational transition in biomolecules.     

一维Chemotaxis模型双曲组的解的存在性及其抛物组的行波解

研究了一类简化的 Keller- Segel模型 pt=εpxx+ a( pwxw) x,wt=λpw- b w,x∈ R,t>0 ,按照 ε=0和 ε>0两种不同的情况模型进行讨论 .当 ε=0时 ,采用特征的方法 ,通过计算特征值与黎曼不等式 ,给出问题存在局部解且不可能有整体解的一个充分条件 .当 ε>0 ,给出了它的行波解的一个形式表达式 .     

Norm behaviour of solutions to a parabolic–elliptic system modelling chemotaxis in a domain of ℝ3

In this paper, we study a parabolic–elliptic system defined on a bounded domain of ?³, which comes from a chemotactic model. We first prove the existence and uniqueness of local in time solution to this problem in the Sobolev spaces framework, then we study the norm behaviour of solution, which may help us to determine the blow‐up norm of the maximal solution. Copyright © 2004 John Wiley & Sons, Ltd.     

Boundedness in a two‐species chemotaxis system

This paper is concerned with the following coupled chemotaxis system with homogeneous Neumann boundary conditions in a bounded domain Ω?Rⁿ(n≥2) with smooth boundary, where λ, χ₁, χ₂, μ₁, μ₂, a₁, a₂, b₁, and b₂ are supposed to be positive and τ = 0,1. In the case τ = 0, based on some energy estimates for both u and v, it is shown that for any parameters, the system possesses a unique globally bounded solution if n = 2. Moreover, when τ = 1, relying on a comparison principle, for a range of parameters, the existence of a unique global bounded classical solution of problem is established for any n≥2 if Ω is convex. Copyright © 2015 John Wiley & Sons, Ltd.     

一个趋化性模型非常数平衡解的存在性

对带两个趋化性参数的趋化性模型平衡解的存在性问题进行研究.在参数满足特定的条件下,应用局部分岔理论得到非常数平衡解的局部分岔结构,从而证明了该趋化性模型存在无穷多个非常数正平衡解.     

Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils

Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (β-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils with Wnt5a caused chemotactic migration and the production of two important chemokines, CXCL8 and CCL2. CCL2 production by Wnt5a was mediated by a pertussis toxin-sensitive G-protein-dependent pathway. Wnt5a also stimulated the phosphorylation of three mitogen-activated protein kinases (MAPKs: ERK, p38 MAPK and JNK) and Akt. Inhibition of ERK, p38 MAPK or JNK by specific inhibitors induced a dramatic reduction in Wnt5a-induced CCL2 production. Supernatant collected from lipopolysaccharide-stimulated macrophages induced neutrophil chemotaxis, which was significantly inhibited by anti-Wnt5a antibody. Our results suggested that Wnt5a may contribute to neutrophil recruitment, mediating the inflammation response.     

Boundedness of solutions to parabolic–elliptic Keller–Segel systems with signal‐dependent sensitivity

This paper deals with the parabolic–elliptic Keller–Segel system with signal‐dependent chemotactic sensitivity function, under homogeneous Neumann boundary conditions in a smooth bounded domain , with initial data satisfying u₀ ≥ 0 and . The chemotactic sensitivity function χ(v) is assumed to satisfy The global existence of weak solutions in the special case is shown by Biler (Adv. Math. Sci. Appl. 1999; 9:347–359). Uniform boundedness and blow‐up of radial solutions are studied by Nagai and Senba (Adv. Math. Sci. Appl. 1998; 8:145–156). However, the global existence and uniform boundedness of classical nonradial solutions are left as an open problem. This paper gives an answer to the problem. Namely, it is shown that the system possesses a unique global classical solution that is uniformly bounded if , where γ > 0 is a constant depending on Ω and u₀. Copyright © 2014 John Wiley & Sons, Ltd.