新辅助化疗在软组织肉瘤治疗中的应用分析

目的研究并探讨新辅助化疗在软组织肉瘤治疗中的应用效果。方法选取2013年1月—2016年6月期间甘肃中医药大学临床医学院收治的软组织肉瘤共80例作为研究对象,采取单盲随机分组法随机分为对照组和观察组各40例,对照组实施手术治疗,观察组在手术前实施新辅助化疗,比较两组患者的保肢率、治疗效果、术后半年复发情况。结果观察组患者的保肢手术率为77.50%,对照组患者为55.00%,差异具有统计学意义(P0.05);观察组患者的治疗总有效率明显高于对照组(P0.05);术后半年随访发现,观察组的复发率明显低于对照组(P0.05);观察组患者在新辅助化疗期间未出现严重的不良反应。结论在软组织肉瘤患者行手术治疗前实施新辅助化疗,可提高患者的保肢率,提高治疗效果,减少复发,有利于改善预后。     

Tissue distribution of capilliposide B,capilliposide C and their bioactive metabolite in mice using liquid ‐tandem mass spectrometry

Lysimachia capillipes Hemsl (Primulaceae), a folk medicinal plant in China, showed significant anti‐tumor activities in vivo and in vitro . Capilliposide B (LC‐B) and capilliposide C (LC‐C) are the main bioactive components in this plant. To explore their tissue distribution, a reliable bioanalytical method for the quantification of LC‐B, LC‐C and their bioactive metabolite, capilliposide A (LC‐A), in mouse tissues was developed and validated. In this study, the tissue distribution profiles of the three compounds were examined after intravenous administration of pure LC‐B and oral administration of total saponins of L. capillipes Hemsl extract (LCE) for 10 days. Method validation was conducted over the curve range 10.0–5000 ng/mL for all three analytes in various tissue homogenates. The relative standard deviation of intra‐day and inter‐day precision of the QC samples was <14.7%, and the accuracy ranged from 85.9 to 114.0%. The results indicated that LC‐B was rapidly and widely distributed throughout the whole body except for muscle following intravenous administration of LC‐B. In addition, LC‐A was only in liver, intestine, lung and stomach. After oral administration of LCE, LC‐B and LC‐C were distributed into various tissues. The highest levels were observed in stomach and intestine.     

Development of solid‐phase microextraction coupled with liquid chromatography for analysis of tramadol in brain tissue using its molecularly imprinted polymer

In this work, performance of a molecularly imprinted polymer (MIP) as a selective solid‐phase microextraction sorbent for the extraction and enrichment of tramadol in aqueous solution and rabbit brain tissue, is described. Binding properties of MIPs were studied in comparison with their nonimprinted polymer (NIP). Ten milligrams of the optimized MIP was then evaluated as a sorbent, for preconcentration, in molecularly imprinted solid‐phase microextraction (MISPME) of tramadol from aqueous solution and rabbit brain tissue. The analytical method was calibrated in the range of 0.004 ppm (4 ng mL⁻¹) and 10 ppm (10 μg mL⁻¹) in aqueous media and in the ranges of 0.01 and 10 ppm in rabbit brain tissue, respectively. The results indicated significantly higher binding affinity of MIPs to tramadol, in comparison with NIP. The MISPME procedure was developed and optimized with a recovery of 81.12–107.54% in aqueous solution and 76.16–91.20% in rabbit brain tissue. The inter‐ and intra‐day variation values were <8.24 and 5.06%, respectively. Finally the calibrated method was applied for determination of tramadol in real rabbit brain tissue samples after administration of a lethal dose. Our data demonstrated the potential of MISPME for rapid, sensitive and cost‐effective sample analysis.     

Depth-adaptive regularized reconstruction for reflection diffuse optical tomography

We study reflection diffuse optical tomography using two-dimensional (2D) continuous-wave source-detector arrays on the surface of semi-infinite medium, aiming at imaging the perfusion and the hemoglobin oxygen saturation variation of human cerebral cortex with brain activation. We had previously formulated the inverse problem with Moore-Penrose inversion. When we use simple regularization in this inverse problem, the reconstruction sensitivity decreases markedly with the depth so that the signal in the deep range may be masked by an unwanted signal in the shallow range. In this paper, we propose a depth-adaptive regularized reconstruction, in which we assign a smaller regularization parameter with the depth. We demonstrate improvement of the three-dimensional (3D) reconstruction uniformity using the proposed scheme.     

Structural, electronic and optical properties of SrCl2 under hydrostatic stress

The results of first-principles theoretical study of the structural, electronic and optical properties of SrCl₂ in its cubic structure, have been performed using the full-potential linear augmented plane-wave method plus local orbitals (FP-APW+lo) as implemented in the WIEN2k code. In this approach both the local density approximation (LDA) and the generalized gradient approximation (GGA) are used for the exchange-correlation (XC) potential. Also we have used the Engel-Vosko GGA formalism, which optimizes the corresponding potential for band structure calculations. We performed these calculations with and without spin-orbit interactions. Including spin-orbit coupling cause to lifts the triple degeneracy at Γ point and a double degeneracy at X point. Results are given for structural properties. The pressure dependence of elastic constants and band gaps are investigated. The dielectric function, reflectivity spectra and refractive index are calculated up to 30 eV. Also we calculated the pressure and volume dependence of the static optical dielectric constant.     

Generic structure of externally driven tearing modes instabilities

A major limit to steady state and advanced high operation of tokamaks of reactor class is due to the onset of tearing modes that develop magnetic and may cause loss of energy confinement or a major disruption. Here the structure of a classical problem about the effects of external control helical fields is analysed and it is shown to offer a general paradigm of response of low order classical and neoclassical tearing modes to a wide class of external perturbations. New results of principle on the structural stability of the response model are obtained, leading to a clear interpretation of the role of “seed islands" in the onset of neo-classical tearing modes and the role of finite ion larmor radius corrections to Ohm's law. Received 12 November 2001 and Received in final form 4 January 2002     

Radiation inhibition effects in the coherent-state many-atom Jaynes-Cummings model

Summary Radiation inhibition in the many-atom Jaynes-Cummings model being a consequence of cooperative as well as cavity detuning effects is examined. Numerical solutions for the time evolution of the atomic population inversion exhibiting quasi-stationary behaviour are presented. Furthermore, the cooperative energy shift of these quasi-stationary states is numerically computed by using a special projection operator. The authors of this paper have agreed to not receive the proofs for correction.     

Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by P and H NMR metabolic images under A 2-T magnetic field

The relationships among tissue edema, lactate accumulation, and intracellular pH in middle cerebral artery (MCA)-occluded rats were investigated with multiecho ¹H magnetic resonance imaging and spatially resolved metabolic images constructed by ¹H and ³¹P nuclear magnetic resonance (NMR) chemical shift imaging (CSI). For the effective and sensitive detection of NMR signals from the brain, outer volume suppression (OVS), reduced k-space sampling and proton irradiation were incorporated into the CSI sequences. The consecutive three measurements of calculated T₂ image, lactate image, and pH image which were required for 3.75 h were repeated for four cycles of 1–16 h after MCA occlusion. Tissue edema and lactate accumulation in the infarcted region were gradually and consistently increased during the 15-h observation period. In contrast, severe acidosis was already detected on the first pH image (2–4.7 h after MCA occlusion); thereafter, the degree of acidosis became milder and showed no further progression. The dissociation between the time courses of the lactate accumulation and pH decrease was clearly demonstrated by the NMR metabolic images. Acid-base balance in cerebral infarction might be affected not only by lactate production but also by complicated interactions with tissue edema and some other factors.     

Quantum theory of rotation angles: The problem of angle sum and angle difference

We reconsider the problem of the sum and difference of two angle variables in quantum mechanics. The spectra of the sum and difference operators have widths of , but angles differing by are indistinguishable. This means that the angle sum and difference probability distributions must be cast into a range. We obtain probability distributions for the angle sum and difference and relate this problem to the representation of nonbijective canonical transformations. Received: 6 December 1997 / Revised: 15 April 1998 / Accepted: 7 May 1998     

A scenario for the electronic state in the manganese perovskites: the orbital correlated metal

We propose a novel scenario for the electronic state in the manganese perovskites. We argue that, at low temperatures and within the ferromagnetic state, the physics of these colossal magnetoresistance compounds may be characterized by a correlated metallic state near a metal insulator transition where the orbital degrees of freedom play the main role. This follows from the observation that a two-band degenerate Hubbard model under a strong magnetic field can be mapped onto a para-orbital single band model. We solve the model numerically using the quantum Monte-Carlo technique within a dynamical mean field theory which is exact in the limit of large lattice connectivity. We argue that the proposed scenario may allow for the qualitative interpretation of a variety of experiments which were also observed in other (early) transition metal oxides. Received: 3 October 1997 / Revised: 9 December 1997 / Accepted: 12 January 1998