Systematic design and development of a flexible wheel for low mass lunar rover

Low mass compact rovers provide cost effective means to explore extra-terrestrial terrains. Use of flexible wheels in such applications where the wheel size is restricted, improves traction at reduced slip and sinkage. Design of a flexible wheel for a given mission is a challenging task requiring consideration of stiffness of rim and spokes, stress induced in the wheel, chassis movement during wheel rotation and the operating mode of the wheel. Also, accurate mathematical models are required to save design and development time and reduce the number of prototypes for selection. It is observed that most of the research papers deal with performance testing of flexible wheels and information on analytical formulation is scarce. Therefore, in the present work, a methodology has been formulated to systematically design a flexible wheel for a low mass lunar rover. The prototype performance is tested and compared with analytical estimates and reasons for difference are investigated. Paper contains details of design criteria, mathematical modelling, realisation of wheel prototype, test fixture and analysis test comparison. Authors believe that this work provides a useful aid to the designer to systematically design flexible wheels for low mass lunar rovers.     

线性模型中自相关的经验似然比检验

研究线性回归模型中的自相关检验问题,用经验似然的方法构造检验统计量,得到了零假设下检验统计量的渐近分布,我们的检验方法不但可以检验一阶自相关,也可以检验高阶自相关,数值模拟表明检验方法具有良好的检验功效.     

On the eigenvalues and eigenvectors of an overlapping Markov chain

Starting with a sequence of i.i.d. [uniform] random variables with m possible values, we consider the overlapping Markov chain formed by sliding a window of size k through the i.i.d. sequence. We study the limiting covariance matrix B_k of this Markov chain and give algorithms for constructing the eigenvectors of B_k. We also discuss the applicability of the results in strengthening Pearsons ² test as well as the relation to approximate entropy and the usefulness in the area of testing the hypothesis of uniformity of random number generators.Mathematics Subject Classification (2000):Primary: 60J10; Secondary: 11K45     

Point-of-Care Testing for the Detection of MicroRNAs: Towards Liquid Biopsy on a Chip

Point-of-care (PoC) testing is revolutionizing the healthcare sector improving patient care in daily hospital practice and allowing reaching even remote geographical areas. In the frame of cancer management, the design and validation of PoC enabling the non-invasive, rapid detection of cancer markers is urgently required to implement liquid biopsy in clinical practice. Therefore, focusing on stable blood-based markers with high-specificity, such as microRNAs, is of crucial importance. In this work, we highlight the potential impact of circulating microRNAs detection on cancer management and the crucial role of PoC testing devices, especially for low-income countries. A detailed discussion about the challenges that should be faced to promote the technological transfer and clinical use of these tools has been added, to provide the readers with a complete overview of potentialities and current limitations.     

Migration and Precipitation of Platinum in Anion-Exchange Membrane Fuel Cells

Despite the recent progress in increasing the power generation of Anion-exchange membrane fuel cells (AEMFCs), their durability is still far lower than that of Proton exchange membrane fuel cells (PEMFCs). Using the complementary techniques of X-ray micro-computed tomography (CT), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray (EDX) spectroscopy, we have identified Pt ion migration as an important factor to explain the decay in performance of AEMFCs. In alkaline media Pt⁺² ions are easily formed which then either undergo dissolution into the carbon support or migrate to the membrane. In contrast to PEMFCs, where hydrogen cross over reduces the ions forming a vertical “Pt line” within the membrane, the ions in the AEM are trapped by charged groups within the membrane, leading to disintegration of the membrane and failure. Diffusion of the metal components is still observed when the Pt/C of the cathode is substituted with a FeCo−N−C catalyst, but in this case the Fe and Co ions are not trapped within the membrane, but rather migrate into the anode, thereby increasing the stability of the membrane.     

Recent studies on advance spectroscopic techniques for the identification of microorganisms: A review

The continuous development of resistance to antibiotic drugs by microorganisms causes high mortality and morbidity. Pathogens with distinct features and biochemical abilities make them destructive to human health. Therefore, early identification of the pathogen is of substantial importance for quick ailments and healthcare outcomes. Several phenotype methods are used for the identification and resistance determination but most of the conventional procedures are time-consuming, costly, and give qualitative results. Recently, great focus has been made on the utilization of advanced techniques for microbial identification. This review is focused on the research studies performed in the last five years for the identification of microorganisms particularly, bacteria using advanced spectroscopic techniques including mass spectrometry (MS), infrared (IR) spectroscopy, Raman spectroscopy (RS), and nuclear magnetic resonance (NMR) spectroscopy. Among all the techniques, MS techniques, particularly MALDI-TOF/MS have been widely utilized for microbial identification. A total of 44 bacteria i.e., 6 Staphylococcus spp., 3 Enterococcus spp., 6 Bacillus spp., 4 Streptococcus spp., 6 Salmonella spp., and one from each genus including Escherichia, Acinetobacter, Pseudomonas, Proteus, Clostridioides, Candida, Brucella, Burkholderia, Francisella, Yersinia, Moraxella, Vibrio, Shigella, Serratia, Citrobacter, and Haemophilus (spp.) were discussed in the review for their identification using the above-mentioned techniques. Among all the identified microorganisms, 21% of studies have been conducted for the identification of E. coli, 14% for S. aureus followed by 37% for other microorganisms.