基于三维成像技术的四轮定位参数建模方法

鉴于现有四轮定位仪参数求取方法误差大、参数项目少、对测量环境要求高等不足,提出了一种基于三维成像技术的四轮定位参数建模方法;该方法通过双摄像机对目标板拍摄获得的图像信息,应用空间向量方法,求取车体运动状态下的轮轴信息,动态建立四轮定位参数测量模型,解决测量平面的动态建立、测量平台的补偿等问题;经过零标定平台测试,当车轮旋转在18~22°时,定位参数求取方法正确有效,通过实车对比测量验证,平均误差小于0.07°。     

Dual-Color Quantum Dot–Encoded Nanoprobe for DNA Assays and Cell Imaging

In this article, a novel dual-color quantum dot–encoded fluorescent nanoprobe was prepared by the reverse microemulsion method and layer-by-layer assembly method. First, red fluorescence–emitting CdTe quantum dots were encapsulated in silica nanoparticles by the reverse microemulsion method. Yellow fluorescence–emitting quantum dots were deposited on the surface of silica nanoparticles to form a dual-color quantum dot@silica beads/quantum dot nanoprobe. Then capture DNA was linked to a QSQ nanoprobe via covalent bonding. We utilized the quantum dot@silica beads/quantum dot nanoprobe to capture and detect the mutant BRAF DNA sequence through the competitive immunoassay method. The resulting quantum dot@silica beads/quantum dot nanoprobe-capture DNA conjugates showed sequence-specific hybridization with target DNA. Furthermore, a multispectral imaging system was utilized to distinguish the quantum dot optical code in the quantum dot@silica beads/quantum dot nanoprobe. The quantum dot@silica beads/quantum dot nanoprobe was used in human osteoblast-like HepG2 cell imaging. The proposed quantum dot@silica beads/quantum dot nanoprobe and decoding analysis method could be used for targeting imaging, biological assays, and early detection of cancer.     

Multi-frequency harmonic arrays: initial experience with a novel transducer concept for nonlinear contrast imaging

Nonlinear contrast imaging modes such as second harmonic imaging (HI) and subharmonic imaging (SHI) are increasingly important for clinical applications. However, the performance of currently available transducers for HI and SHI is significantly constrained by their limited bandwidth. To bypass this constraint, a novel transducer concept termed multi-frequency harmonic transducer arrays (MFHA's) has been designed and a preliminary evaluation has been conducted. The MFHA may ultimately be used for broadband contrast enhanced HI and SHI with high dynamic range and consists of three multi-element piezo-composite sub-arrays (A-C) constructed so the center frequencies are 4f(A) = 2f(B) = f(C) (specifically 2.5/5.0/10.0 MHz and 1.75/3.5/7.0 MHz). In principle this enables SHI by transmitting on sub-array C receiving on B and, similarly, from B to A as well as HI by transmitting on A receiving on B and, likewise, from B to C. Initially transmit and receive pressure levels of the arrays were measured with the elements of each sub-array wired in parallel. Following contrast administration, preliminary in vitro HI and SHI signal-to-noise ratios of up to 40 dB were obtained. In conclusion, initial design and in vitro characterization of two MFHA's have been performed. They have an overall broad frequency bandwidth of at least two octaves. Due to the special design of the array assembly, the SNR for HI and SHI was comparable to that of regular B-mode and better than commercially available HI systems. However, further research on multi-element MFHA's is required before their potential for in vivo nonlinear contrast imaging can be assessed.     

Use of tunable second‐harmonic signal from KNbO3 nanoneedles to find optimal wavelength for deep‐tissue imaging

Nonlinear optical (NLO) responses of perovskite‐type nanostructures have a variety of potential applications owing to the highly efficient frequency conversion guaranteed by both the material itself and the nanometer‐scale configuration. KNbO₃ (KN) nanoneedles have been identified as a promising NLO material because of the superior broadband frequency conversion efficiency, and if incident light is propagating in a direction perpendicular to the axis of a nanoneedle, then the phase‐matching constraint can be relaxed. Here, the second‐harmonic generation (SHG) and third‐harmonic generation (THG) responses of both individual and clustered KN nanoneedles are reported. Based on these results, a novel method is proposed for determining the optimal excitation wavelength for NLO imaging of several biological samples, with KN nanoneedles acting as NLO agents. The method is shown to provide the optical features in the focal plane and a more reliable estimation of the optimal excitation wavelength for deep‐tissue imaging.     

Analysis of the lateral displacement and optical path difference in wide-field-of-view polarization interference imaging spectrometer

The mechanism of beam splitting and principle of wide-field-of-view compensation of modified Savart polariscope in the wide-field-of-view polarization interference imaging spectrometer (WPIIS) are analyzed and discussed. Formulas for the lateral displacement and optical path difference (OPD) produced by the modified Savart polariscope are derived by ray-tracing method. The theoretical and practical guidance is thereby provided for the study, design, modulation, experiment and engineering of the polarization interference imaging spectrometers and other birefringent Fourier-transform spectrometers based on Savart polariscopes.     

多波段微量TNT成像探测的数值分析和实验研究

建立了CO2激光器辐照微量爆炸物温升分布三维模型,对激光辐照过程和冷却过程中8~14μm和3~5μm波段内的目标表面辐射温度变化特性分别进行分析.利用设计的探测系统对目标进行初步探测,用8~14μm和3~5μm热像设备对目标进行观察分析.研究表明:在10.6μm激光照射过程中,8~14μm波段内沾有TNT目标的辐射温度分别由TNT、基底在8~14μm波段的发射率和对激光辐照的反射率共同决定;在3~5μm内目标辐射温度主要由TNT、基底在3~5μm波段的自身发射率决定.在探测过程中,8~14μm波段内沾染TNT区域的辐射温度明显高于周围区域,而在3~5μm波段内,目标表面辐射温度整体下降,并且沾染区域的辐射温度变得低于周围.     

The Munich Compact Light Source: initial performance measures

While large‐scale synchrotron sources provide a highly brilliant monochromatic X‐ray beam, these X‐ray sources are expensive in terms of installation and maintenance, and require large amounts of space due to the size of storage rings for GeV electrons. On the other hand, laboratory X‐ray tube sources can easily be implemented in laboratories or hospitals with comparatively little cost, but their performance features a lower brilliance and a polychromatic spectrum creates problems with beam hardening artifacts for imaging experiments. Over the last decade, compact synchrotron sources based on inverse Compton scattering have evolved as one of the most promising types of laboratory‐scale X‐ray sources: they provide a performance and brilliance that lie in between those of large‐scale synchrotron sources and X‐ray tube sources, with significantly reduced financial and spatial requirements. These sources produce X‐rays through the collision of relativistic electrons with infrared laser photons. In this study, an analysis of the performance, such as X‐ray flux, source size and spectra, of the first commercially sold compact light source, the Munich Compact Light Source, is presented.     

用于同步辐射光源的成像板粉末衍射系统

报道了我们研制的一套成像板粉末衍射装置,对其误差来源进行了详细的分析讨论,并与衍射仪进行了比较.该装置的半径为143.3mm,最大测量角度范围不160°，最大角度(2q )偏差小于0.03°,这些性能指标已被实验所证实,完全可应用于粉末衍射全谱的测量.     

Near field imaging in microwave regime using double layer split-ring resonator based metamaterial

A planar metamaterial structure consisting of two layers of split-ring resonator (SRR) arrays is demonstrated to form the image of a point source with subwavelength resolution. The source frequency is swept through the resonance gap of the metamaterial layers and the lateral field intensity distribution is recorded on the transmission side of the metamaterial. When the source is tuned to the resonance frequency of SRRs, the metamaterial acts as a high permeability medium and a distinct image with subwavelength resolution in the lateral direction is obtained. Increasing the distance between the individual SRR layers reduces the interlayer coupling, and the intensity and spatial resolution of the image decrease rapidly.     

同步辐射X射线成像光束线劳厄双晶单色器设计

上海光源X射线成像光束线采用多极扭摆器(wiggler)作为辐射光源, 提出一种劳厄双弯晶单色器的设计方案. 计算结果显示, 可获得固定出口的平行单色光束, 能量调谐范围覆盖19—120keV, 在33keV时, 输出光子通量及通量密度分别为1.9×10¹³phs/s和3.8×10¹⁰phs/s/mm². 分析了劳厄晶体的聚焦及单色化性能, 计算了输出光子通量及单色器的热负载情况. 与传统的双平晶方案相比, 本设计在获得高通量和解决热负载等方面有明显的优越性, 并能有效控制热形变.