抗差自适应模型预测滤波及其在组合导航中的应用

为了提高捷联惯导(SINS)/天文导航(CNS)/合成孔径雷达(SAR)组合导航系统的定位精度,在吸收模型预测滤波和抗差自适应滤波算法优点的基础上,提出了一种新的抗差自适应模型预测滤波算法。该算法首先利用模型预测滤波估计出系统模型误差,并对其进行实时修正,以抑制系统模型误差对导航解算精度的影响;然后利用抗差自适应因子控制观测异常,抑制观测噪声对导航解算精度的影响。将提出的算法应用于SINS/CNS/SAR组合导航系统进行仿真验证,并与抗差自适应滤波进行比较,结果表明,提出的算法得到的姿态误差、速度误差和位置误差分别在[0.2,0.2]、[0.3m/s,0.3m/s]和[6 m,6 m]以内,滤波性能明显优于抗差自适应滤波算法,说明该算法能有效抑制系统模型误差及观测异常对导航解的影响,提高组合导航的解算精度。     

A theoretical study on electronic structure and structure–activity properties of novel drug precursor 6‐acylbenzothiazolon derivatives

In this work, electronic properties and structure–activity relationship (SAR) parameters of 20 novel drug precursor 6‐acylbenzothiazolon derivatives with analgesic activity have been investigated theoretically by performing Austin Model‐1 (AM1) and DFT‐B3LYP/6‐31G (d) calculations with the aim to correlate the properties of each substance—particularly electronic properties and SAR parameters—with the biological interactions that are linked to their pharmacological effects. Their molecular properties were related to the biological activity of these drug precursor molecules. The relationship between octanol–water partition coefficient (log P) and each of the SAR parameters [E_LUMO–HOMO, molecular volume (V_m), ionization potential (IP), electron affinity, electronegativity (χ), chemical hardness (η), chemical softness (S), electrophilic index (ω), and molar refractivity] present linear correlation except for IP and χ. This result suggests that there are future prospects for designing or developing new drugs based on the correlation between the theoretically calculated parameters. According to AM1 calculation, the values of heat of formation of 6‐acylbenzothiazolon derivatives are negative (exothermic), which shows that these molecules are thermodynamically stable. E_LUMO–HOMO energy levels of the studied molecules are 4–5 eV, which also indicate that they are kinetically unstable. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011     

Study of the influence of the laterality of mobile phone use on the SAR induced in two head models

The objective of this paper is to investigate and to analyse the influence of the laterality of mobile phone use on the exposure of the brain to radio-frequencies (RF) and electromagnetic fields (EMF) from different mobile phone models using the finite-difference time-domain (FDTD) method.The study focuses on the comparison of the specific absorption rate (SAR) induced on the right and left sides of two numerical adult and child head models. The heads are exposed by both phone models operating in GSM frequency bands for both ipsilateral and contralateral configurations. A slight SAR difference between the two sides of the heads is noted. The results show that the variation between the left and the right sides is more important at 1800 MHz for an ipsilateral use. Indeed, at this frequency, the variation can even reach 20% for the SAR10g and the SAR1g induced in the head and in the brain, respectively. Moreover, the average SAR induced by the mobile phone in the half hemisphere of the brain in ipsilateral exposure is higher than in contralateral exposure. Owing to the superficial character of energy deposition at 1800 MHz, this difference in the SAR induced for the ipsilateral and contralateral usages is more significant at 1800 MHz than at 900 MHz. The results have shown that depending on the phantom head models, the SAR distribution in the brain can vary because of differences in anatomical proportions and in the geometry of the head models. The induced SAR in child head and in sub-regions of the brain is significantly higher (up to 30%) compared to the adult head.This paper confirms also that the shape/design of the mobile and the location of the antenna can have a large influence at high frequency on the exposure of the brain, particularly on the SAR distribution and on the distinguished brain regions.     

In vitro assessment of 3-T MRI issues for a bioabsorbable,coronary artery scaffold with metallic markers

Objective

Coronary artery stents are made from metallic mesh and, therefore, to ensure patient safety, these implants must be evaluated to determine risks associated with MRI. Recently, bioabsorbable scaffolds, which have metallic markers, have been developed for use in the coronary arteries. Because of the metallic materials, these implants may present issues for patients undergoing MRI. Therefore, the objective of this investigation was to assess MRI issues (i.e., magnetic field interactions, MRI-related heating, and artifacts at 3 T) for a new bioabsorbable, coronary artery scaffold with metallic markers.

Methods

A bioabsorbable, coronary artery scaffold (Mirage Microfiber Scaffold) underwent assessments for magnetic field interactions, MRI-related heating, and artifacts at 3-Tesla using standard techniques. MRI-related heating was evaluated with the scaffold placed in a gelled-saline-filled phantom and MRI was performed at an MR system reported, whole body averaged SAR of 2.9 W/kg for 15 minutes. Artifacts were characterized using T1-weighted spin echo and gradient echo, pulse sequences.

Results

There were no magnetic field interactions. The highest temperature rise was 1.6 °C (highest background temperature rise, 1.6 °C). Artifacts were relatively small in relation to the size and shape of this coronary artery scaffold. Notably, the lumen of the scaffold could be visualized on the GRE pulse sequence.

Conclusion

The results demonstrated that the coronary artery scaffold is acceptable (or “MR conditional,” using current MRI labeling terminology) for a patient undergoing an MRI procedure at 3 T or less. To our knowledge, this is the first bioabsorbable, coronary artery scaffold that has been evaluated for MRI issues.     

基于子带补偿的弹载聚束SAR成像算法

弹载SAR成像常用非线性变标类算法改善聚焦效果.然而,非线性变标算法由于自身的局限性,在三维匀加速聚束SAR成像模式中非常容易失效.针对这一问题,本文提出了一种子带补偿法,并将该方法结合到弹载SAR聚束成像算法中.新算法不引入三次相位操作,可有效补偿随目标位置走动的多普勒调频率.仿真结果和分析表明,与常用的非线性变标类算法相比,本文所提算法在运算量、成像结果、适用性上都具有优越性,具有一定的工程应用价值和理论意义.     

基于边缘与SURF算子的SAR与可见光图像配准方法

鉴于SAR(synthetic aperture radar)与可见光图像的成像机理存在很大差别,使得其同名特征的提取和配准十分困难,但在某些情况下,这两类图像的边缘存在一定的相关性。提出一种基于边缘与SURF(speed-up robust feature)算子的图像配准方法。通过适当预处理增强图像间的共性,采用综合性能比较好的Canny算子提取两幅图像共有的边缘特征,在边缘图像的基础上提取SURF特征;通过比值提纯法进行特征点粗匹配,RANSAC(random sample consensus)算法剔除误匹配点,计算仿射变换模型从而实现SAR与可见光图像的自动配准。实验结果表明:该算法的正确匹配率为100%,均方根误差为0.852个像素,配准精度达到亚像素水平。     

Representation of molecular structure using quantum topology with inductive logic programming in structure–activity relationships

The requirement of aligning each individual molecule in a data set severely limits the type of molecules which can be analysed with traditional structure activity relationship (SAR) methods. A method which solves this problem by using relations between objects is inductive logic programming (ILP). Another advantage of this methodology is its ability to include background knowledge as 1st-order logic. However, previous molecular ILP representations have not been effective in describing the electronic structure of molecules. We present a more unified and comprehensive representation based on Richard Bader's quantum topological atoms in molecules (AIM) theory where critical points in the electron density are connected through a network. AIM theory provides a wealth of chemical information about individual atoms and their bond connections enabling a more flexible and chemically relevant representation. To obtain even more relevant rules with higher coverage, we apply manual postprocessing and interpretation of ILP rules. We have tested the usefulness of the new representation in SAR modelling on classifying compounds of low/high mutagenicity and on a set of factor Xa inhibitors of high and low affinity.     

Improved SNR in linear reordered 2D bSSFP imaging using variable flip angles

This article presents a variable flip-angle approach for balanced steady-state free precession (bSSFP) imaging, which allows increases in signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) while keeping specific absorption rate (SAR) constant or reduces SAR for given CNR and SNR. The gain in SNR is achieved by utilizing the higher signal in the transient phase. Flip-angle variation during the echo train is realized using a trigonometric function with M steps (ramp length). Variation is combined with a linear k-space reordering such that outer parts of k-space are sampled using a lower flip angle α_min, while the central part of k-space is acquired with a higher flip angle α_max. No additional preparation or dummy cycles are applied prior to data acquisition. Several variation schemes with different starting flip angles α_min and ramp length M are considered. For example, using α_min=1° and M=96, α_max can be set to 47° without exceeding SAR limits at 3 T and gaining up to 50% in SNR, while, conventionally, α=34° is the maximal possible flip angle. Resolution seems unaffected in volunteer imaging. In all cases, no transient artifacts due to flip-angle variation were observed. This article demonstrates the use of flip-angle variations in bSSFP to increase SNR and CNR while keeping SAR constant, which is especially important at higher field strengths. Flip-angle variation can also be combined with other methods such as parallel imaging techniques for further SAR reduction.     

机载SAR用的GPS/SINS组合导航系统研究

提出了进行SINS姿态校正的四元补偿算法。采用闭环KF（卡尔曼滤波）技术实时校正惯性仪表误差，补偿四元数误差，修正位置，速度误差，GPS／SINS组合导航系统样机的试验结果表明：采用该提出的算法后，组合导航精度较高，在组合导航过程中若去掉GPS信息，短时间内纯SINS的导航精度很高，能够满足SAR对运动补偿精度的要求，待恢复GPS信息后，组合导航系统继续正常工作。     

INS／SAR组合导航系统中的误差修正方法

—本文介绍了ＩＮＳ／ＳＡＲ（合成孔径雷达）组合导航系统中的误差修正原理和方法，描述了如何获得观测量和构造ＩＮＳ／ＳＡＲ组合滤波器。给出的仿真结果证明，这种修正方法能大大提高导航精度，并且具有很强的初始捕获和对准能力。