Accounting for nonspecific enhancement in neuronal tract tracing using manganese enhanced magnetic resonance imaging

Manganese enhanced MRI (MEMRI) is an emerging technique for tracing neuronal pathways in vivo. However, manganese may leak into blood vessels or cerebrospinal fluid (CSF) after local injection and can be circulated to and taken up by brain regions that may not have connections to the targeted pathways. Comparing enhancement time courses after intranasal injection with intravenous infusion of MnCl₂ in rats, the early enhancements in the pituitary gland (Pit) and hippocampus indicate the contrasts in those regions in the olfactory tract-tracing experiment were caused by such systemic effects. Since the Pit has easy access to manganese from the blood and its signal is proportional to other brain regions after intravenous infusion, it was used as an internal reference for the systemic effects. Applying intensity normalization by the Pit signal to tract-tracing data from the olfactory bulb led to reduced contrast in the hippocampus. These results demonstrate that nonspecific enhancements in MEMRI tract-tracing studies may have to be taken into account and that normalization by the Pit signal can compensate these effects.     

反射式旋转对称光学系统中的偏振像差分析

为了控制反射式旋转对称光学系统中的偏振效应,对该类系统中的偏振像差进行了分析。在偏振像差理论的基础上,通过偏振光线追迹的方法,导出反射式旋转对称光学系统的偏振像差的计算公式,提出了反射界面产生的偏振像差的影响因子,对影响其偏振像差的因素进行了分析。实例分析结果表明,对于具有宽光谱、大入射角、大视场等特点的反射式旋转对称光学系统,要想提高其光学系统的性能,必须控制光学系统的偏振像差。提出尽可能减小入射角的大小,并通过薄膜设计减小偏振分离来降低系统中的偏振效应,是控制反射式旋转对称光学系统中的偏振像差的有效措施。     

线激光束均匀化整形方法研究

为解决核物理工程、表面热处理、激光加工、激光通信中传输激光束的均匀性问题,提出采用三角楔柱透镜改善线激光均匀性的新方法,并在ZEMAX开发环境下建立了整形光路系统的理论模型。利用所建立的模型,分析了整形柱透镜在不同半径、斜面夹角、透镜介质折射率等参数下光束的均匀性。研究表明：在远场条件下,通过改变整形柱透镜的参数,能够得到能量分布均匀的线激光。在实际应用中,可以采用1个半圆柱和2个相同三角楔胶合成型的简单工艺。进一步模拟发现,两种整形系统所得到的均匀度和线宽一致。     

漫反射各向异性散射介质内的温度热流场

本文采用射线踪迹结合节点分析法和谱带模型,研究了漫反射不透明边界下吸收、发射、各向异性散射介质内的热辐射传递过程。考虑介质辐射能的入射和散射方向,导出漫反射、不透明边界、各向异性散射介质的辐射传递系数。在辐射平衡的情况下,考察了表面发射率和散射反照率对介质内辐射热流和温度场的影响。研究表明,介质不透明边界处存在温度跃迁现象,而且,内界面发射率越大,相应界面温度跃迁越小。     

利用边缘相位校正实现光束整形的高精度优化

提出利用边缘相位校正的新方法,校正用追迹法设计的产生环形光束的衍射光学元件的相位分布,从而实现光束整形中的高精度优化。通过将高斯光束整形为环形光束,将该方法、G-S(Gerchberg-Saxton)算法和改进的G-S算法设计得到的整形结果作了比较,结果表明,G-S算法的整形结果虽然衍射效率最大,但是均方根值和最大偏差也太大;改进的G-S算法可以有效的降低均方根值和最大偏差,但衍射效率也有较大的下降;而用边缘相位校正可以在衍射效率略微下降的情况下,更大的降低均方根值和最大偏差,其整形结果是综合了衍射效率、均方根值和最大偏差这三个评价指标以后得到的最优化结果,已接近理想的环形光束。     

1×7锥形混合棒塑料光纤耦合器

利用光线追迹法进行数值仿真得到了锥形混合棒塑料光纤耦合器的分光比与其长度的关系.数值仿真表明:这种耦合器的分光比随锥形光波导长度增加,在0.143(即均分处)上下呈振荡型变化.选择一均分且分光比变化平缓的区域作为制作光波导的长度,通过拉伸粗的光波导棒成锥形且达到所需的长度,并采用精密的机械连接,制作出了1×7塑料光纤耦合器.测试数据表明:这种塑料光纤耦合器具有很高的均匀性.     

Alkaloids from the Leaves and Stems of Daphniphyllum calycinum

One new alkaloid, named caldaphnidine H ( 1 ), together with eight known ones, daphnioldhanin G ( 2a ), methyl homosecodaphniphyllate ( 3 ), daphnezomine M ( 4 ), daphniyunine A ( 5 ), calyciphylline A ( 6 ), deoxycalyciphylline B ( 7 ), deoxyisocalyciphylline B ( 8 ), and calyciphylline B ( 9 ) was isolated from the leaves and stems of Daphniphyllum calycinum. The structure of 1 was established by spectral methods, especially 2D‐NMR techniques. The structure of daphnioldhanin G ( 2b ) reported previously was revised to 2a mainly by single‐crystal X‐ray diffraction and spectral analysis.     

Building Functionality into 4′‐Hydrazone Derivatives of 2,2′: 6′,2″‐Terpyridine

The syntheses of the five 2,2′: 6′,2″‐terpyridine (tpy) ligands 5 – 9 functionalized in the 4′‐position with a hydrazone substituent RR′C?N? NH (R=R′=Me; R=H, R′=4‐BrC₆H₄, 4‐O₂NC₆H₄, 4‐MeOC₆H₄, or 3,5‐(MeO)₂C₆H₃) are described. Protonation of the tpy domain of the ligands is facile. Solution behaviour has been studied by NMR and electronic spectroscopies. Representative structural data are presented for neutral and monoprotonated ligands, and illustrate that H‐bonding involving the formal amine NH unit is a dominant structural motif in all cases.