Markierung von Humanserumalbumin mit 131J durch elektrochemische Oxydation von Jodid zum Jod

Es wird über eine Methode und deren optimale Bedingungen berichtet, die eine schnelle, schonende und fernbediente Markierung von Humanserumalbumin mit ¹³¹ J gestattet. Die Markierungsausbeuten, bezogen auf das eingesetzte Jod, sind gut reproduzierbar und liegen bei über 90%.     

Mathematical models for job-shop scheduling problems with routing and process plan flexibility

As a result of rapid developments in production technologies in recent years, flexible job-shop scheduling problems have become increasingly significant. This paper deals with two NP-hard optimization problems: flexible job-shop scheduling problems (FJSPs) that encompass routing and sequencing sub-problems, and the FJSPs with process plan flexibility (FJSP-PPFs) that additionally include the process plan selection sub-problem. The study is carried out in two steps. In the first step, a mixed-integer linear programming model (MILP-1) is developed for FJSPs and compared to an alternative model in the literature (Model F) in terms of computational efficiency. In the second step, one other mixed-integer linear programming model, a modification of MILP-1, for the FJSP-PPFs is presented along with its computational results on hypothetically generated test problems.     

大一学生化学实验室安全基础知识调查研究*

为考察大一学生化学实验室安全基础知识,对天津理工大学化学化工学院大一学生警示标识、危险化学品性质、废弃物处理及意外处置等安全知识进行问卷调查。结果表明:60.4%的学生将易燃标识与氧化剂标识混淆;在危险化学品性质和酸/碱撒漏处理方面有待加强。基于以上结果,在后续安全教育过程中,普及GHS标识及MSDS,对相关知识进行针对性的查漏补缺;充分利用线上资源,弥补线下教育因时间有限、容量有限导致的不足。     

On the importance of behavioral operational research: The case of understanding and communicating about dynamic systems

We point out the need for Behavioral Operational Research (BOR) in advancing the practice of OR. So far, in OR behavioral phenomena have been acknowledged only in behavioral decision theory but behavioral issues are always present when supporting human problem solving by modeling. Behavioral effects can relate to the group interaction and communication when facilitating with OR models as well as to the possibility of procedural mistakes and cognitive biases. As an illustrative example we use well known system dynamics studies related to the understanding of accumulation. We show that one gets completely opposite results depending on the way the phenomenon is described and how the questions are phrased and graphs used. The results suggest that OR processes are highly sensitive to various behavioral effects. As a result, we need to pay attention to the way we communicate about models as they are being increasingly used in addressing important problems like climate change.     

How to acquire new biological activities in old compounds by computer prediction

Due to the directed way of testing chemical compounds' in drug research and development many projects fail because serious adverse effects and toxicity are discovered too late, and many existing prospective activities remain unstudied. Evaluation of the general biological potential of molecules is possible using a computer program PASS that predicts more than 780 pharmacological effects, mechanisms of action, mutagenicity, carcinogenicity, etc. on the basis of structural formulae of compounds, with average accuracy 85%. PASS applications to both databases of available samples included hundreds of thousands compounds, and small collections of compounds synthesized by separate medicinal chemists are described. It is shown that 880 compounds from Prestwick chemical library represent a very diverse pharmacological space. New activities can be found in existing compounds by prediction. Therefore, on this basis, the selection of compounds with required and without unwanted properties is possible. Even when PASS cannot predict very new activities, it may recognize some unwanted actions at the early stage of R&D, providing the medicinal chemist with the means to increase the efficiency of projects.     

Mössbauer Spectroscopy on Nuclear Power Plant Materials

Experimental results of original irradiated reactor pressure vessel surveillance specimens are presented and discussed in the paper. In 1994, the new Extended Surveillance Specimen Program for Nuclear Reactor Material Study was started in collaboration with the nuclear power plant (NPP) Bohunice and NPP Research Institute Trnava (Slovakia). Three batches of special prepared Mössbauer samples (after 1, 2 and 3 years stay in irradiation channels) were measured and interpreted using the new four components approach of Mössbauer spectra evaluation with the aim to observe microstructural changes due to thermal and neutron treatment resulting from operating conditions in NPP. The systematic changes in the relative areas of Mössbauer spectra components were observed and discussed.     

模糊广义判断矩阵的一致性检验及合成排序

决策评价过程中往往包含诸多不确定性、随机性和模糊性,广义判断下的ＡＨＰ－ＧＪＡＨＰ是一种广义ＡＨＰ,Ｆｕｚｚｙ 环境下的ＧＪＡＨＰ决策方法是应用集值统计的方法,在区间判断标度基础上确定模糊判断矩阵元素的正模糊数表示,并根据模糊集理论的扩展原理,求得Ｆｕｚｚｙ 环境下的模糊排序权值向量。本文给出模糊广义判断矩阵的一致性定义,讨论了各类判断形式条件下的一致性检验法与Ｆｕｚｚｙ 环境下递阶层次结构中的合成排序问题     

On the M/G/1 retrial queueing system with linear control policy

Summary This paper is concerned with the study of a newM/G/1 retrial queueing system in which the delays between retrials are exponentially distributed random variables with linear intensityg(n)=α+nμ, when there aren≥1 customers in the retrial group. This new retrial discipline will be calledlinear control policy. We carry out an extensive analysis of the model, including existence of stationary regime, stationary distribution of the embedded Markov chain at epochs of service completions, joint distribution of the orbit size and the server state in steady state and busy period. The results agree with known results for special cases.     

Rate of Convergence for the Empirical Distribution Function and the Empirical Characteristic Function of Mixing Processes

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Thermal aqueous liquid chromatography—the TALC technique

Thermal Aqueous Liquid Chromatography (TALC) using pure water as a mobile phase should be a very attractive technique promoting the use of liquid chromatography in routine analysis, either in the laboratory or in future on-line process control. This simple form of chromatography, the selectivity of which depends on the fixed phase only, would allow the use of flame ionization as an almost universal, low-cost detector in liquid chromatography. The potential of the TALC technique is illustrated by selected examples.