Effects of Relative Permeability History Dependence on Two-Phase Flow in Porous Media

Hysteresis phenomena in multi-phase flow in porous media has been recognized by many researchers and widely believed to have significant effects on the flow. In an attempt to account for these effects, a theoretical model for history-dependent relative permeabilities is considered. This model is incorporated into 1-D two-phase nondiffusive flow system and the corresponding flow is predicted. Flow history is observed to have a notable impact on the saturation profile and fluids breakthrough.     

Motion of inviscid fluid tongues and bubbles in a Hele-Shaw cell occupied by a viscoelastic fluid

Problems of steady-state motion of an inviscid fluid tongue or bubble in a Hele-Shaw cell occupied by a viscoelastic fluid are considered. The problems generalize the well-known Saffman-Taylor problems [1, 2] in the approximation in which the pressure jump on the interface between the two fluids depends on the normal velocity of the interface [4]. In the zero approximation the results obtained by means of an iteration technique are in good agreement with the analytic solutions obtained by Saffman and Taylor [1, 2].__________Translated from Izvestiya Rossiiskoi Academii Nauk, Mekhanika Zhidkosti i Gaza, No. 1, 2005, pp. 117–123. Original Russian Text Copyright © 2005 by Entov, Kolganov, and Kolganova.     

On the Validity of Darcy's Law for Stable High-Concentration Displacements in Granular Porous Media

Recently, it has been suggested that Darcy's Law might not be applicable for modelling miscible, density-dependent flow in porous media. To investigate this, three sets of careful laboratory column experiments were performed on coarse and medium sands, consisting of upward displacement of water by sodium chloride solutions with concentrations ranging from 5 to 200g/l. Data on salt concentrations and water pressures were collected in horizontal transects along the flow direction. Salt concentration data were also collected in the influent and exit lines. The experimental data were analysed using a simplified approach based on Darcy's Law alone, applied with the assumption of a sharp interface. Darcy's Law was used to estimate porous medium permeability by fitting predictions to experimental data. Consistent estimates of permeability were obtained for each set of experiments. The results indicate that Darcy's Law adequately describes high concentration displacements through saturated coarse- and medium-grained porous media.     

主裂纹与微裂纹相互作用问题的有效数值计算方法

提出了平面弹性介质中主裂纹与微裂纹相互作用问题的有效数值计算 方法. 通过把适于单一裂纹的Bueckner原理扩充到含有多裂纹的一般体系，将原问题分解 为承受远处载荷不含裂纹的均匀问题，和在远处不承受载荷但在裂纹面上承受面力的多裂纹 问题. 于是，以应力强度因子作为参量的问题可以通过考虑后者(多裂纹问题)来解决，而 利用提出的杂交位移不连续法，这种多裂纹问题是容易数值求解的. 列举 Cai和 Faber为评价主裂纹与微裂纹相互作用问题的近似方法而列举的算例，说明 该数值方法对分析平面弹性介质中主裂纹与微裂纹相互作用问题既简单又非常有效.     

Stochastic analysis of a displacement front in a randomly heterogeneous medium

The behavior of the interface in a two-phase immiscible fluid flow in a randomly heterogeneous porous medium is investigated. The medium is described by the permeability distribution which represents a random field with given statistical characteristics. When the approach proposed is used, it turns out to be possible to relate the statistical characteristics of the interface with the statistical characteristics of the permeability field and the properties of the phases. On the basis of this relation an important characteristic of the two-phase flow, namely, the average saturation distribution in the neighborhood of the interface, can be calculated.     

不同材料参数和内压的轮胎对单腹板轮毂变形的影响

将轮胎材料简化为各向同性超弹性材料特性，考虑轮胎与轮毂和地面之间的三维接触以及轮胎中钢丝圈的影响，建立飞机单腹板机轮整体结构有限元模型。主要分析不同轮胎材料参数和内压下，单腹板轮毂轮缘处的径向变形，结果表明；轮毂剖面上测点的应变值与实验结果基本一致。轮胎下沉量与轮毂测点的径向变形和轮毂所受的载荷基本呈线性关系；凸出一侧的轮缘变形最大；轮胎下沉量较大时。轮胎材料参数对轮毂的径向变形影响明显；轮毂测点径向变形在1-2.5mm时，相同的径向变形，轮毂受到的总载荷受轮胎材料参数变化而变化，而在变形较大或较小时，影响不明显。对于同一种轮胎材料，不同的内压，轮毂的变形减轻比较大，气压越高，对于相同的轮胎下沉量，轮毂受到总体荷载也越高。     

奇性校正特解场法计算任意点应力和位移

本文将边界应力积分方程中的强奇性边界积分化为Ｃａｕｃｈｙ主值积分，证明了该主值积分的存在性，并给出它在变量替换中的比尺附加项显式；运用刚体位移法和单位应力场法将强奇性主子块和应力奇性系数矩阵表为同行副子块的线性组合，再配用极坐标变换和适当的数值求积计算各副子块。本法无论对平面问题还是空间问题，是光滑边界点、侧棱点还是角点，有限域或无限域，受载还是变温，都一概适用，而且可以扩展用来计算近边界点，公式统一，程序通用，数值效果良好。     

A new description for dispersion

Chang and Slattery (1986) introduced a simplified model for dispersion that contains only two empirical parameters, both of which can be determined in one-dimensional experiments. The traditional model for dispersion (Nikolaevskii, 1959; Scheidegger, 1961; de Josselin de Jong and Bossen, 1961; Bear, 1961a; Peaceman, 1966; Bear, 1972) has three empirical parameters, two of which can be measured in one-dimensional experiments while the third, the transverse dispersivity, must be measured in experiments in which a two-dimensional concentration profile develops. For the common one-dimensional experiment in which the signs of the concentration gradient and of the velocity field are different, the simplified model and the traditional model give identical results. For a one-dimensional experiment in which the signs of the concentration gradient and of the velocity field are at least sometimes the same and for two- and three-dimensional flows, the simplified model of Chang and Slattery (1986) gives results that can differ from those predicted using the traditional model.Only the experimental data of Bear (1961b) and of Yule and Gardner (1978) are sufficiently complete to permit a comparison of the two models. Considering the quality of the experimental data, we can not distinguish between the predicted profiles based upon the simplified model and those based upon the traditional model.     

Strand displacement amplification for ultrasensitive detection of human pluripotent stem cells

Human pluripotent stem cells (hPSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), provide a powerful model system for studies of cellular identity and early mammalian development, which hold great promise for regenerative medicine. It is necessary to develop a convenient method to discriminate hPSCs from other cells in clinics and basic research. Herein, a simple and reliable biosensor for stem cell detection was established. In this biosensor system, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4) were used to mark human pluripotent stem cells (hPSCs). Antibody specific for SSEA-3 was coated onto magnetic beads for hPSCs enrichment, and antibody specific for SSEA-4 was conjugated with carboxyl-modified tDNA sequence which was used as template for strand displacement amplification (SDA). The amplified single strand DNA (ssDNA) was detected with a lateral flow biosensor (LFB). This biosensor is capable of detecting a minimum of 19 human embryonic stem cells by a strip reader and 100 human embryonic stem cells by the naked eye within 80 min. This approach has also shown excellent specificity to distinguish hPSCs from other types of cells, showing that it is promising for specific and handy detection of human pluripotent stem cells.