Online Flowing Colloidosomes for Sequential Multi-analyte High-Throughput SERS Analysis

3D plasmonic colloidosomes are superior SERS sensors owing to their high sensitivity and excellent tolerance to laser misalignment. Herein, we incorporate plasmonic colloidosomes in a microfluidic channel for online SERS detection. Our method resolves the poor signal reproducibility and inter-sample contamination in the existing online SERS platforms. Our flow system offers rapid and continuous online detection of 20 samples in less than 5 min with excellent signal reproducibility. The isolated colloidosomes prevent cross-sample and channel contamination, allowing accurate quantification of samples over a concentration range of five orders of magnitude. Our system demonstrates high-resolution multiplex detection with fully preserved signal and Raman features of individual analytes in a mixture. High-throughput multi-assay analysis is performed, which highlights that our system is capable of rapid identification and quantification of a sequence of samples containing various analytes and concentrations.     

Interband Absorption Enhanced Optical Activity in Discrete Au@Ag Core–Shell Nanocuboids: Probing Extended Helical Conformation of Chemisorbed Cysteine Molecules

Detailed understanding of the interaction between a chiral molecule and a noble metal surface is essential to rationalize and advance interfacial self‐assembly of amino acids and metal‐mediated anchoring of proteins. Here we demonstrate that individual Au@Ag core–shell nanocuboids can serve as a plasmonic reporter of an extended helical network formed among chemisorbed cysteine molecules, through generating an interband absorption enhanced, Ag‐surface‐exclusive circular dichroism (CD) band in the UV region. The observed unusual, strong CD response in the hybrid Au@Ag–cysteine system can be used to probe in real time conformational evolution and structural rearrangement of biomolecules in general and also monitor the interfacial interaction between a metal surface and an adsorbed molecule, opening up the possibility of using Ag nanostructures as promising stereochemically attuned nanosensors.     

黑体辐射公式的多种推导及其在近代物理构建中的意义(Ⅰ)

黑体辐射是近代物理史上一只会下金蛋的鹅,是近代物理的摇篮。黑体辐射研究的意义还在于这是唯一一个涉及c,k,h三个普适常数的物理情景。黑体辐射谱抗测量误差的特性带来了辐射标准和绝对温度参照,谱分布公式对模型的不敏感则使得黑体辐射成为独特的物理研究母题。黑体辐射谱分布公式,普朗克多角度推导过,德拜推导过,艾伦菲斯特推导过,劳厄推导过,洛伦兹和庞加莱深入讨论过,泡利推导过,玻色推导过,爱因斯坦在20多年的时间里多角度推导过且产出最为丰硕,近代还有从相对论角度的推导,每一个角度的推导都带来了物理学的新内容,这包括量子力学、固体量子论、受激辐射、量子统计、相对论统计,等等。认真回顾黑体辐射研究的历史细节,考察其中的思想概念演化,不啻于体验一次教科书式的学(做)物理之旅,比如也可以尝试给出能量局域分立化的简单新证明。