W波段边廊模回旋管准光模式变换器的研究与设计

详细研究并设计了一个由Vlasov螺旋开口辐射器和两级曲面反射器组成的边廊模回旋管准光模式变换器.首先采用几何光学理论研究了设计的Vlasov型准光模式变换器的工作机理,在此基础上,再利用矢量绕射理论中的口径场积分法和表面电流积分法编写了模拟仿真程序,最后结合W波段边廊模回旋管的具体设计参数,应用所编写程序详细分析了工作模式在此变换器中的模式变换过程.模拟结果表明,W波段回旋管中的TE_12,2边廊模在输出窗处被转换为能量集中的准Gauss波束.     

三苯基膦：转换硫醇保护的纳米粒子成[Au25(PPh3)10(SR)5Cl2]2+

我们在此报道了一种未曾发现的有趣现象：尽管[Au₂₃(SC₆H₁₁)₁₆]⁻、Au₂₄(SC₂H₄Ph)₂₀ (Ph:苯环)、Au₃₆(TBBT)₂₈ (TBBTH:对叔丁基苯硫酚)、Au₃₈(SC₂H₄Ph)₂₄、混合Au_x(SC₂H₄Ph)_y团簇及3 nm的金纳米粒子有不同的组成、结构、尺寸和保护性硫醇配体,但它们在三苯基膦(PPh₃)作用下,均能统一地经由亚稳的[Au₁₁(PPh₃)₈Cl₂]²⁺最终转化为稳定的双二十面体[Au₂₅(PPh₃)₁₀(SR)₅Cl₂]²⁺ (SR:硫醇配体)。换句话说,三苯基膦是这些硫醇保护的纳米粒子的统一转化器。然而,聚乙烯吡咯烷酮(PVP)/柠檬酸盐(Citrate)保护的金纳米粒子和[Ag₂₅(SPhMe₂)₁₈]⁻ (Me:甲基)在同样的条件下,却不能转化为[Au₂₅(PPh₃)₁₀(SR)₅Cl₂]²⁺或[Ag₂₅(PPh₃)₁₀(SR)₅Cl₂]²⁺,暗示了硫醇保护的金纳米粒子具有与三苯基膦反应的独特性能。另外,我们考察了配体对双二十面体[Au₂₅(PPh₃)₁₀(SR)₅Cl₂]²⁺团簇荧光性能的影响。     

Axion detection with negatively coupled cavity arrays

Using eigenmode analysis and full 3D FEM modelling, we demonstrate that a closed cavity built of an array of elementary harmonic oscillators with negative mutual couplings exhibits a dispersion curve with lower order modes corresponding to higher frequencies. Such cavity arrays may help to achieve large mode volumes for boosting sensitivity of the axion searches, where the mode volume for the composed array scales proportional to the number of elements, but the frequency remains constant. The negatively coupled cavity array is demonstrated with magnetically coupling coils, where the sign of next-neighbour coupling (controlled with their chirality) sets the dispersion curve properties of the resonator array medium. Furthermore, we show that similar effects can be achieved using only positively coupled cavities of different frequencies assembled in periodic cells. This principle is demonstrated for the multi-post re-entrant system, which can be realised with an array of straight metallic rods organised in chiral structures.     

基于全可编程SoC和LabVIEW的磁共振接收系统设计

本文提出了基于全可编程片上系统（System-on-a-Chip,SoC）和实验室虚拟仪器工程平台（Laboratory Virtual Instrument Engineering Workbench,LabVIEW）的磁共振信号接收系统设计.使用集成了ARM（Advanced RISC Machines）和现场可编程门阵列（Field Programmable Gate Array,FPGA）的全可编程SoC作为接收机的主芯片,利用Xilinx提供的数字信号处理（Digital Signal Processing,DSP）开发工具System Generator设计了数字下变频（Digital Down Converter,DDC）算法,并实现了接收机硬件电路.使用可视化编程平台LabVIEW设计了磁共振上位机软件,完成了磁共振信号的显示、存储和与接收机通信的工作,提高了软件开发效率.实验结果表明,本文设计的接收机能正确接收磁共振回波信号,且具有较高的信噪比.     

单轴各向异性异向介质平板波导中的导模特性

 推导了介电常数张量和磁导率张量中各分量带有不同符号的单轴各向异性异向介质平板波导的导行条件。根据分量符号的正负组合,分情况讨论了导行TE波的偶模特性,画出了平板波导中为实横波数时的布里渊图。结果表明,在特定条件下此平板波导中有无穷多导模,这与传统介质波导及各向同性异向介质平板中只有有限数量模式存在有很大不同。此外,还发现当分量参数满足一定条件时,出现了多个虚横波数的传输模式解,并且该模式存在高频截止。     

Targeted Synthesis of Anthranilic Diamides Insecticides Containing Trifluoroethoxyl Phenylpyrazole

Aseries of novel anthranilic diamides analogues(9a-9t) containing trifluoroethoxyl pyrazole moiety was designed and synthesized and their insecticidal bioactivities against Mythimna separata(Walker, M. separata) and Plutellaxylostella (P. xylostella) were evaluated. The structures of the title compounds were confirmed by ¹H NMR, ¹³C NMR and HRMS. Preliminary insecticidal activities showed that some of the title compounds possessed good to excellent bioactivities towards M. separata and P. xylostella. Compounds 9c and 9t exhibited 100% mortality rate against M. separate at 0.2 mg/L. For the P. xylostella, the synthesized compounds(9c-9e, 9i and 9o) showed 70%, 80%, 75%, 65% and 60% insecticidal activities at 1×10^-6 mg/L, respectively, higher than that of chlorantraniliprole(0). Based on excellent insecticidal activities, the mode of the action was tested by the calcium-imaging technique, the results of which demonstrated that the novel compounds shared the same target with chlorantraniliprole. The binding pose of the most active compound 9t in RyRs of P. xylostella was predicted by molecular docking, which showed that compound 9t interacted with the residues Glu140(A) and His147(A) via hydrogen bond.     

高功率聚变磁体电源桥臂直通故障分析及仿真

高功率聚变磁体电源采用三电平中点钳位型(NPC)电压源变流器(VSC)拓扑，在变流器桥臂直通故障情况下，其直流侧电容的充放电使故障暂态过程较为复杂，为变流器故障分析带来挑战。针对这一问题，以3kV、6kA三电平IGCT大功率VSC为背景，建立了桥臂直通故障暂态等效数学模型。将整个故障过程分为直流侧电容放电和二极管导通两个阶段，详细分析了该故障情况下电压及电流的变化趋势，为后期保护方案的设计奠定基础。Matlab仿真结果表明了该分析方法的可靠性。     

Deciphering the Biological Activities of Antifungal Agents with Chemical Probes

The growing number of fungal infections caused by pathogens resistant to one or more classes of antifungal drugs emphasizes the threat that these microorganisms pose to animal and human health and global food security. Open questions remain regarding the mechanisms of action of the limited repertoire of antifungal agents, making it challenging to rationally develop more efficacious therapeutics. In recent years, the use of chemical biology approaches has resolved some of these questions and has provided new promising concepts to guide the design of antifungal agents. By focusing on examples from studies carried out in recent years, this minireview describes the key roles that probes based on antifungal agents and their derivatives have played in uncovering details about their activities, in detecting resistance, and in characterizing the interactions between these agents and their targets.