含IIIA或VA族杂原子的碳原子簇负离子的研究

在自制的仪器上，以脉冲激光束在高真空中溅射适当的样品，产生了一系列合有1个VA族原子（N、P、As）或ⅢA族原子（B、Al）及13个以下碳原子的原子簇负离子。在实验记录的飞行时间质谱中，这些簇离子的信号强度均因其碳原子数的奇偶而发生交替变化．对实验结果的分析研究显示：这些簇离子均为直链构型．VA或ⅢA族原子位于链的一端，所有成簇原子的价键均得到满足．     

荧光标记-高效液相色谱测定多肽（PC2～PC6）的研究

基于多肽(Polypeptides PC2~PC6)中富有巯基(-SH)官能团,其与单溴二胺(Monobromobimanes mBBr)能够发生缩合反应,生成具有荧光信号的多肽衍生物;通过优化色谱分离条件,建立了高效液相色谱(荧光检测器)测定多肽的方法;试验中利用质谱鉴定了PCs与mBBr缩合反应的比例关系。结果显示,通过比较PCs标记前后化合物的质谱图,PCs与mBBr反应比例关系为1∶1,稳定性好;高效液相色谱-荧光法测定多肽化合物,五种化合物间分离度较好,出峰时间集中在16.6~22.0min间;PC2,PC3,PC4,PC5和PC6线性相关性系数>0.999 1,方法定量限分别为0.3,0.05,0.3,0.5和0.8 mg·L-1,回收率范围为83.0%~102.0%;重线性较好,RSD<2.0%,该方法实现了多肽类化合物快速、准确定量分析。     

Structural and optical properties of CuSe2 nanocrystals formed in thin solid Cu–Se film

This paper describes the structural and optical properties of Cu–Se thin films. The surface morphology of thin films was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). Formation of Cu–Se thin films is concluded to proceed unevenly, in the form of islands which later grew into agglomerates. The structural characterization of Cu–Se thin film was investigated using X-ray diffraction pattern (XRD). The presence of two-phase system is observed. One is the solid solution of Cu in Se and the other is low-pressure modification of CuSe₂. The Raman spectroscopy was used to identify and quantify the individual phases present in the Cu–Se films. Red shift and asymmetry of Raman mode characteristic for CuSe₂ enable us to estimate nanocrystal dimension. In the analysis of the far-infrared reflection spectra, numerical model for calculating the reflectivity coefficient of layered system, which includes film with nanocrystalite inclusions (modeled by Maxwell-Garnett approximation) and substrate, has been applied.     

由季戊四醇合成季戊四硫醇的新方法

以季戊四醇为原料,先合成四对甲苯磺酸季戊四醇酯,然后四对甲苯磺酸季戊四醇酯与硫氰酸钾在N,N-二甲基甲酰胺中加热反应,生成了2,3,7,8-四硫螺[4,4]壬烷,2,3,7,8-四硫螺[4,4]壬烷经四氢化铝锂还原、酸化,得到季戊四硫醇.产物结构经熔点、红外光谱、质子核磁共振谱、拉曼光谱鉴定.     

Mass Spectrometry of Some Benzylidene Imidazolidinediones and Thiazolidinediones. II- chlorobenzyl imidazolidinedione and Fluoro or Chlorobenzyl Thiazolidinedione Compounds

In the present investigation, a study of the electron impact mass spectrometry data is reported for seven compounds of a series of some 3-(4-chlorobenzyl)-5-benzylidene-imidazolidine-2, 4-diones and 3-(4-fluoro or chlorobenzyl)-5-benzylidene-thiazolidine-2, 4-diones previously synthesized.     

A robust spin-coated optical sensing device for rapid determination of predominant metal ions in wastewater streams

The potential of an optical sensing material for determination of metal ions in wastewater streams is presented. The initial results in the development of a chromo-ionophore-based optical sensor for metal ions are detailed. An azo dye species, 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (BrPADAP), together with an ionophore and plasticiser was immobilised in a film of poly(vinyl chloride) (PVC). Initial investigations using the dye-impregnated sensing film showed a reproducible and reversible response to Pb(II) ions in aqueous solution. The response of this sensing film to Pb(II) at pH 6 was found to be linear in the 0.1-10 mg/L range, with a %RSD of 1.55%. The film can be regenerated by immersion in a low-pH buffer solution. The authors demonstrate how this method shows potential for analysis using once-off sensing probes. The sensing film response for Pb(II) occurs within 30 s.     

Measurement of the Rates of Diffusion of Halomethanes into Polymer Films Using ATR-FTIR Spectroscopy

Polymer-modified attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and FEWS (fibre-optic evanescent wave) spectroscopy have been very successful to date for sensitive detection of organic pollutants in water utilising the mid-infrared (MIR) region of the electromagnetic spectrum (4000-400 cm^?1). This sensing approach involves the use of different polymer films for preconcentration with optimisation of the sensor related to the rate of diffusion of solvent molecules into these polymer films. Compounds such as chloroform, bromoform, bromodichloromethane and dibromochloromethane which are collectively referred to as trihalomethanes (THMs) were analysed in this work. A gaseous phase experimental design was used and from experimental data the rate of diffusion of each of the halomethanes was quantified based on a Fickian type diffusion model. Individual diffusion coefficient values were found to be in the range 3.38 E-10 ± 0.01 E-10 to 4.72 E-08 ± 0.42 E-08 cm² s^?1. Multicomponent effects were observed for mixtures of compounds diffusing into polyisobutylene and ethylene-propylene copolymer.     

Isolation and Characterization of Badge Hydrolysis Products

Heating a suspension of Bisphenol A diglycidyl ether (BADGE) in 20 : 80 tetrahydrofuran/water at 70°C and subsequent passage of the resulting solution through C18 columns allowed isolation and purification to > 97% of each of the two hydrolysis products 2-[4-(2,3-dihydroxypropoxy) phenyl]-2-[4-(2,3-epoxypropoxy)phenyl]propane (1HP) and 2,2-bis[4-(2,3-dihydroxypropoxy)phenyl] propane (2HP), which were characterized by UV, IR, ₁H and _I3C NMR spectroscopy and mass spectrometry.     

High-resolution laser ablation-inductively coupled plasma-mass spectrometry imaging of cisplatin-induced nephrotoxic side effects

Two-dimensional elemental mapping (bioimaging) via laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was performed on 5 μm thick formalin-fixed, paraffin-embedded kidney tissue sections from Cynomolgus monkeys administered with increasing pharmacological doses of cisplatin. Laterally resolved pixels of 1 μm were achieved, enabling elemental analysis on a (sub-)cellular level. Zones of high Pt response were observed in the renal cortex, where proximal tubules are present, the epithelium of which is responsible for partial reabsorption of cisplatin. Histopathological evaluation, of hematoxylin and eosin-stained serial sections, adjacent to the sections probed via LA-ICP-MS, revealed minimal to mild cisplatin-related lesions (<100 μm) in the renal cortex. Necrotic proximal tubules with sloughed epithelial cells in their lumen could be linked directly to the areas with the highest accumulation of cisplatin, indicating a direct link between cellular concentration and toxicity, thereby providing more insight into the mechanisms through which renal damage occurs.     

Electrochemical Detection of Cardiac Biomarkers Utilizing Electrospun Multiwalled Carbon Nanotubes Embedded SU‐8 Nanofibers

In this paper we demonstrate synthesis and characterization of MWCNTs embedded SU‐8 electrospun nanofibers and their application towards ultrasensitive detection of cardiac biomarkers using Electrochemical Impedance spectroscopy (EIS). The composite nanofibers have excellent electrical and transduction properties owing to the presence of MWCNTs in addition to ease of functionalization and biocompatibility, which can be attributed to the presence of SU‐8. Thus the synthesized nanofibers are ideal candidates for sensitive biosensor applications. As a proof concept, the detection of cardiac biomarkers, Myoglobin (Myo), cardiac Troponin I (cTn I) and Creatine Kinase MB (CK‐MB) is demonstrated. The synthesized nanofibers were functionalized with the antibodies of the biomarkers and the detection was carried using Electrochemical Impedance Spectroscopy, an excellent technique for understanding the adsorption kinetics. A minimum detection limit of nano‐gram/ml is demonstrated using this nanobiosensor platform.