Insights into the Allosteric Effect of SENP1 Q597A Mutation on the Hydrolytic Reaction of SUMO1 via an Integrated Computational Study

Small ubiquitin-related modifier (SUMO)-specific protease 1 (SENP1) is a cysteine protease that catalyzes the cleavage of the C-terminus of SUMO1 for the processing of SUMO precursors and deSUMOylation of target proteins. SENP1 is considered to be a promising target for the treatment of hepatocellular carcinoma (HCC) and prostate cancer. SENP1 Gln597 is located at the unstructured loop connecting the helices α4 to α5. The Q597A mutation of SENP1 allosterically disrupts the hydrolytic reaction of SUMO1 through an unknown mechanism. Here, extensive multiple replicates of microsecond molecular dynamics (MD) simulations, coupled with principal component analysis, dynamic cross-correlation analysis, community network analysis, and binding free energy calculations, were performed to elucidate the detailed mechanism. Our MD simulations showed that the Q597A mutation induced marked dynamic conformational changes in SENP1, especially in the unstructured loop connecting the helices α4 to α5 which the mutation site occupies. Moreover, the Q597A mutation caused conformational changes to catalytic Cys603 and His533 at the active site, which might impair the catalytic activity of SENP1 in processing SUMO1. Moreover, binding free energy calculations revealed that the Q597A mutation had a minor effect on the binding affinity of SUMO1 to SENP1. Together, these results may broaden our understanding of the allosteric modulation of the SENP1−SUMO1 complex.     

Gabor Analysis on Finite Product of Cyclic Groups

We present a complete characterization of Gabor frame operators on finite dimensional Hilbert space $L^2(\Gamma)$, where $\Gamma = \mathbb{Z}_{m_1} \times \mathbb{Z}_{m_2} \times \dots \times \mathbb{Z}_{m_p}$ and $m_1,m_2,\dots,m_p$ are positive integers. The notion of generalized $B$-modulation and generalized $B$-translation is introduced and some significant properties of the generalized pseudo $B$-Gabor like frames are discussed.     

Brewster-angle cut doubled light shutter

New types of doubled electro-optic, and low voltage controlled doubled elasto-optic light shutters containing Brewster-angle cut crystals instead of separate polarizers are investigated. Light transmission characteristics show that the devices without polarizers can give a modulation depth of about 20%.     

基于串行最小频移键控的8进制调制的研究

提出了一种新型的基于串行结构的最小频移键控调制技术,产生了相位连续,频谱宽度窄,每码元时间有两次π/2相移,类似于传统最小频移键控调制信号,给出了该调制方案的理论推导,并将其应用于8进制的多维多阶调制系统中。理论和仿真分析了不同的8进制调制方案在频谱特性,残留色散容限,自相位调制容限的不同,还分析了其受到系统滤波带宽的影响。最后仿真实现了通过350km的色散完全补偿的光纤120Gb/s的数据传输。     

温度对铌酸锂电光相位调制特性的影响

利用折射率椭球基本理论对线性电光效应进行了分析,对单轴晶体铌酸锂电光相位调制器的温度特性进行了研究。通过计算机进行数值模拟计算,分析了加电场时光通过LiNbO3电光调制器后出射光的相位变化与温度间的关系,得出在横向和纵向调制中温度对相位改变的影响。研究发现,无论在横向还是在纵向调制下,入射光偏振方向不同但其各自受温度影响的相位变化趋势大体一致,即随着晶体中温度的增加而增大。计算结果表明,LiNbO3电光调制的最佳使用方案为：电场沿x主轴方向施加,入射光偏振方向为感应主轴x’方向,且LiNbO3电光调制器粟用横向相位调制方式。     

天然气管道泄漏可调谐二极管激光遥感探测的研究

天然气管道泄漏不仅造成经济损失而且是危险之源。传统的天然气管道泄漏检测技术效率低、速度慢,难以满足实际应用的需要。近年来以近红外二极管激光吸收光谱为基础的光学传感器由于具有灵敏度高、体积小、重量轻和无需维护等优点而得到了广泛的应用。文章以可调谐二极管激光吸收光谱和谐波探测技术为基础进行天然气管道泄漏遥感探测技术的研究,采用二次谐波与一次谐波信号的比值作为系统浓度标定,结果显示浓度与比值之间具有较好的一致性。文章还就不同地形散射体对探测结果的影响进行了测量和分析,实验结果表明二次谐波与一次谐波信号比值标定技术对便携式二极管激光光学测量能够很好的满足实际应用的需要。     

Unidimensional continuous-variable quantum key distribution with discrete modulation

In this paper, we proposed an unidimensional continuous-variable quantum key distribution (CV-QKD) protocol with discrete modulation, which waives the necessity in one of the quadrature modulations and further simplified the implementation of the CV-QKD protocol. On the basis of the Heisenberg uncertainty relation, we analyze the boundary between the unphysical and physical region. Besides, we utilize a novel proof approach to achieve a lower bound valid of transmission distance. This scheme shows an available method to further simplified the implementation of the QKD.     

Cross-gain modulation in closely spaced energy states quantum dash semiconductor optical amplifiers

A detailed small-signal analysis of cross-gain modulation is performed for closely spaced energy state quantum dash (QDsh) semiconductor optical amplifier (SOA). The analysis takes into account the carrier transition in all electron and hole states, the gain dispersion of the active layer, the effect of the energy detuning between the probe and pump signals and the effect of doping on the characteristics of cross-gain wavelength conversion. Our analysis reveals that broadband conversion efficiency can be obtained in QDsh SOA when the energy of the pump signal is at − 20 meV below the ground state. Also we find that large 3 dB bandwidth can be achieved when the energy of the pump and the probe signals is at + 30 meV. Our analysis shows that doping the dashes with P-type concentration can enhance the efficiency and the intrinsic 3 dB bandwidth of cross-gain wavelength conversion.     

非腔长匹配相干叠加脉冲锁模激光器的理论研究

提出了一个新的非腔长匹配相干叠加脉冲锁模激光器的物理模型,建立了它的数学方程,并进行了模拟计算.计算结果给出了各个参数对相干叠加脉冲锁模激光器运转的影响,以及脉冲宽度压缩速度和各参数之间的关系,获得了实现非腔长匹配相干叠加脉冲锁模激光器运转的最佳条件.     

用频谱分析法测量声光驻波调制器的调制度

从调制的基本概念出发，指出声光驻波调制器件为宽带频率调制型。讨论了调制度概念的成立条件和适用范围。理论上求出其成立条件为ｖ＜０．９（ｖ＝２πＬ△ｕ／λ为衍射光强Ｉ（θ，ｔ）中的自变量）。鉴于一般驻波型声光器件都是含有一定的行波成份，但行波声场和驻波声场在拉曼－奈斯衍射范围内衍射角均遵从ｓｉｎθｍｉ＝土ｍλ／，故两者在空间上是无法分开的。文中给出了从频域上测量调制度Ｍ的一种新方法。并给出了零级和一般衍射光的测量值。