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211.
F. M. Bautista J. M. Campelo A. Garcia D. Luna J. M. Marinas A. A. Romero M. R. Urbano 《Reaction Kinetics and Catalysis Letters》1997,62(1):47-54
The vapor-phase catalytic alkylation of phenol with methanol and dimethyl carbonate on a series of differently prepared CrPO4 (Cr/P=1) and CrPO4-AlPO4 (CrAIP) catalysts, has been studied at different temperatures (473–673 K). The reaction is first order in phenol, giving
a mixture of O- and C-alkylated products (C-alkylation taking place preferentially at theortho-position). Moreover, dimethyl carbonate is a better methylating agent than methanol. 相似文献
212.
N.V. Loginova T.V. Kovalchuk R.A. Zheldakova A.A. Chernyavskaya N.P. Osipovich G.K. Glushonok G.I. Polozov V.N. Povalishev V.L. Sorokin O.I. Shadyro 《Polyhedron》2006,25(18):3603-3610
Cu (II) complexes with 3,5-di(tert-butyl)-1,2-benzenediol (I), 4,6-di(tert-butyl)-1,2,3-benzentriol (II) and sulfur-containing sterically hindered o-diphenol derivatives such as 4,6-di(tert-butyl)-3-(2-hydroxyethylsulfanyl)-1,2-benzenediol (III) and 2-[4,6-di(tert-butyl)-2,3-dihydroxyphenylsulfanyl]acetic acid (IV) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, ESR, XPS, XPD and conductivity measurements. Antifungal activities of these ligands and their respective Cu (II) complexes have been determined against Aspergillus niger, Fusarium sp., Penicillium lividum, Mucor sp. and Botrytis cinerea. Most of the compounds (both the free ligands and the complexes) exert pronounced antifungal activities (RI 70%), and virtually all of them (apart from the Cu(LII)2 complex) have the highest inhibitory properties (RI = 100%) against B. cinerea. 相似文献
213.
Darja?Rudan-Tasic Cveto?KlofutarEmail author 《Monatshefte für Chemie / Chemical Monthly》2004,135(7):773-784
Summary. The freezing temperatures of dilute aqueous solutions of some poly(oxyethylene) glycols (PEG, HO–(CH2CH2O)
n
–H, n varying from 4 to 117) were measured over a solute to solvent mass ratio from 0.0100 to 0.3900. The second and third osmotic virial coefficient (A
22 and A
222) of poly(oxyethylene) glycols in aqueous solution were determined. The molecular weight dependence of the second virial coefficient can be described by a simple relation A
22=2×10–5
M
n
1.86, and the third virial coefficient is A
222=0.038A
22
2. The activity coefficients of the solute were calculated using the Gibbs-Duhem equation as applied by Bjerrum. From the osmotic and activity coefficients the excess Gibbs energies of solution, as well as the respective partial molar functions of solute and solvent and the virial pair interaction coefficients for the excess Gibbs energies were estimated. The second and the third osmotic virial coefficients are correlated with the Mc-Millan-Mayer virial coefficients. 相似文献
214.
Organophosphorus pesticides parathion, chlorpyrifos, and malathion inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7)
via phosphorylation of its active site. AChE reactivators and anticholinergics are compounds used as antidotes in the case of
intoxication by these AChE inhibitors. In this work, chlorpyrifos, a representative member of this pesticide family, was used
to inhibit the AChE activity of rat brain. The effect of twenty-one structurally different AChE reactivators was tested in vitro and subsequently, the relationship between their chemical structure and biological activity was outlined. 相似文献
215.
四川地区宫颈癌组织HPV18和HPV45 E6基因突变分析 总被引:1,自引:0,他引:1
采用聚合酶链反应技术对四川地区2003~2004年收集的60例宫颈癌患者的癌组织DNA进行人乳头瘤病毒(HPV) E6基因扩增, 获得HPV18和45型E6基因. 序列分析发现, 18型三例E6基因有同样的两处同义突变; 45型两例E6基因发生突变, 一例有两处碱基突变, 另一例发生六处碱基突变, 其中两处涉及氨基酸变化, 均位于E6抗原决定簇区. HPV45型E6基因中134位c→t, 157位c→t, 259位g→t和341位t→c的碱基点突变未见报道. 另外, 该地区HPV18和45型突变株之间存在碱基互变, 它们之间的最小差异比野生型HPV18和HPV45之间的差异小4.05%, 该数值比在非洲发现的突变株的要小很多, 该结果支持HPV18和HPV45可能起源于非洲的观点. 相似文献
216.
L. Leite D. Jansone M. Fleisher H. Kazhoka J. Popelis N. Veretennikova I. Shestakova I. Domracheva E. Lukevics 《Chemistry of Heterocyclic Compounds》2004,40(6):715-724
The respective 4-(arylvinyl)lactones and compounds of the Michael adduct type were synthesized by the condensation of substituted benzaldehydes with 3-cyano-4,6,6-trimethyl-5,6-dihydro-2-pyranone in the presence of catalytic amounts of sodium hydroxide. It was shown by the semiempirical AM1 method that the indicated products can be formed through one and the same intermediate compound. Some of the synthesized phenylvinyl-5,6-dihydro-2-pyranones have a cytotoxic effect, and this corresponds to the prognosis of the OREX expert system. 相似文献
217.
许多三唑类化合物具有优良的杀菌和植物生长调节活性 ,如三唑酮、三唑醇、烯效唑、烯唑醇等 ,对常见真菌病害具有很好的防治效果 ,并具有增产、抗倒和生长调节作用 ,已成为重要的杀菌剂类型 [1] .为筛选新型高活性三唑类杀菌剂和探讨其活性与结构间的关系 ,我们利用生物等排体理论以常规三唑类杀菌剂三唑酮为先导物设计合成了 1 6个含芳硫基的新三唑类化合物 ,其合成路线如下 :RCCH2 BrO+HNNNB NRCCH2O NNHAC-Na ACBr2NRCCHOBrNN(1 ) (2 ) (3 )3 +SH R′B NRCCHOS R′NN (4 )RCCH2 CH2 NMe2 .HClO+HNNNH2 O… 相似文献
218.
John H.T Luong Caide Xiao Š.Mircea Leabu Xiaolan Li Shashi Uniyal Bosco M.C Chan 《Analytica chimica acta》2004,501(1):61-69
Electric cell-substrate impedance sensing (ECIS) was applied to assess the structure-function of α2β1 integrin, receptor for collagen and laminin. On collagen-coated gold electrodes, expression of this integrin on human rhabdomyosarcoma (RD) cells (RDX2C2) yielded a five-fold increase in resistance when compared with mock transfected RD (RDpF) cells (34.5±5.2 versus 6.5±0.8 Ω/cell). An intermediate level of 16±2 Ω/cell was measured upon expression of an α2β1 mutant that lacked the α2 cytoplasmic domain (RDX2CO). On laminin, the resistance measured for RDX2C2 cells was also higher but only twice that of RDpF cells at 71±4 and 37±4 Ω/cell, respectively. In comparison, RDX2CO cells (38±4 Ω/cell), exhibiting no enhanced adhesive function, yielded a similar result to that of RDpF cells. On fibronectin, RDX2C2 and RDpF cells, exhibiting comparable levels of adhesion, were similar in resistance measurements at 85±5and 89±7 Ω/cell, respectively. It has been shown that deletion of α2 cytoplasmic domain results in dysregulated recruitment of the α2β1 mutant to focal adhesion complexes that mediate binding of fibronectin. RDX2CO cells on fibronectin, exhibiting reduced adhesive function, was associated with noticeably lower resistance (60±4 Ω/cell). Monitoring electroporation of the RD plasma membrane also indirectly validated cell attachment as reflected by the resistance measured. Results from this study demonstrated the potential of ECIS for study of the structure-function of βl integrin adhesion receptors. 相似文献
219.
An oligosaccharide homologue named SnS-2 was isolated from the root of Scrophularia ningpoensis Hemsl.SnS-2 was purified by means of gel-permeation chromatography and ion-exchange chromatography. Its physicochemical properties, including carbohydrate content and molecular weight were determined. The structure of SnS-2 was elucidated by chemical methods along with ^1H and ^13C NMR spectroscopy, including two-dimensional DQCOSY and H-detected ^1H, ^13C HMQC experiments. These results show that SnS-2 possesses a backbone consisting of terminal α-Galp-(1→, α-Galp-(1→6), α-Glcp-(1→6) and nonreducing end β-Fruf-(2→. The bioactive assay showed that it could inhibit the growth of Lewis pulmonary carcinoma implanted in mice. 相似文献
220.
Yong Deng Da Cheng Yang Yi Shen Yu Guo Zhong 《中国化学快报》2007,18(1):7-9
Based on the structure-activity relationships and antiangiogenic mechanism of RGD-containing peptides,a series of 5-amino- 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives were synthesized.The structures were characterized by ~1H NMR,MS and elementary analysis.There ability to inhibit angiogenesis were evaluated by chick embryo chorioallantoic membrane assay at 10~(-5) mol/L.Compounds 7a and 7b displayed obvious antiangiogenic activity. 相似文献