医疗体制改革的博弈分析

医疗体制改革是我国制度改革的一项重要内容,建立完善医疗卫生体系也是构建和谐社会的一项基本要求.现阶段,我国在医疗卫生领域中还存在许多突出的问题.本文从博弈论的角度出发,通过建立的博弈模型,分析了医疗机构、政府主管部门及患者三者之间的博弈关系,并对医疗体制改革提出相应对策.     

New Textile Applications of Cyclodextrins

New areas of applications of cyclodextrins with textiles are possible. The abilityof cyclodextrins to form inclusion complexes can be used, e.g., to remove malodorfrom textile materials. The permanent fixation of cyclodextrins offers new textileswith interesting properties. Thus the formation of body odor is reduced by thecomplexation of the organic compounds of sweat. The release of perfumes fromcyclodextrins is possible by the use of textiles with fixed cyclodextrins. Pharmaceutical compounds are also set free in contact with the skin. Last but not least the analysis of the different compounds of the human sweat complexed by the cyclodextrins offers new possibilities in medical diagnostics.     

Synthetic Strategies for (−)‐Cannabidiol and Its Structural Analogs

(?)‐Cannabidiol ((?)‐CBD), a non‐psychoactive phytocannabinoid from Cannabis, and its structural analogs have received growing attention in recent years because of their potential therapeutic benefits, including neuroprotective, anti‐epileptic, anti‐inflammatory, anxiolytic, and anti‐cancer properties. (?)‐CBD and its analogs have been obtained mainly based on extraction from the natural source; however, the conventional extraction‐based methods have some drawbacks, such as poor quality control along with purification difficulty. Chemical‐synthetic strategies for (?)‐CBD could tackle these issues, and, additionally, generate novel (?)‐CBD analogs that exhibit advanced biological activities. This review concisely summarizes the historic and recent milestones in the synthetic strategies for (?)‐CBD and its analogs.     

提取医用黄腐酸的优化方案

本文介绍如何用正交试验法选择提取医用黄腐酸的最优方案 ,使提取出的医用黄腐酸达到最佳提取率 ,并符合国家药典标准     

Estimating Probabilities of Diabetes Mellitus Using Neural Networks

Abstract

Classification problems are often encountered in medical diagnosis. This paper presents an introduction to classification theory and shows how artificial neural networks can be used for classification. We also map out a bootstrapped procedure for interval estimation of posterior probabilities. The entire procedure is illustrated using the diabetes mellitus data in Pima Indians.     

Simultaneous determination of ten flavonoids of crude and wine‐processed Radix Scutellariae aqueous extracts in rat plasma by UPLC‐ESI‐MS/MS and its application to a comparative pharmacokinetic study

Radix Scutellariae (RS) is a herbal medicine with various pharmacological activities to treat inflammation, respiratory and gastrointestinal infections, etc. In this study, a rapid, sensitive and selective UPLC‐ESI‐MS/MS method was developed for simultaneous determination of 10 flavonoids – scutellarin, scutellarein, chrysin, wogonin, baicalein, apigenin, wogonoside, oroxylin A‐7‐O‐glucuronide, oroxylin A and baicalin – from RS aqueous extracts in rat plasma with propyl paraben as internal standard (IS). Chromatographic separation was achieved on a C₁₈ column using gradient elution with the mobile phase consisting of methanol and water (containing 0.1% formic acid) at a flow rate of 0.2 mL/min. The detection was performed in multiple reaction monitoring mode using electrospray ionization in negative mode. The validated method showed good linearity over a wide concentration range (r >0.9935). The intra‐ and interday assay variabilities were <9.5% and <12.4% for all analytes, respectively. The extraction recovery ranged from 71.2 to 89.7% for each analyte and IS. This method was successfully applied to pharmacokinetic comparision after oral administration of crude and wine‐processed RS aqueous extracts. There were significant differences in some pharmacokinetic parameters of most analytes between crude and wine‐processed RS. This suggested that wine‐processing exerted effects absorption of most flavonoids. Copyright © 2014 John Wiley & Sons, Ltd.     

Reactive blue 19 adsorption behaviors of magnesium hydroxide modified biochar derived from the traditional Chinese medical residual

This study examined the reactive blue 19 (RB-19) adsorption behaviors of magnesium hydroxide modified biochar (MBC) derived from the traditional Chinese medical residual. The obtained MBC was characterized using Scanning Electron Microscope (SEM), Fourier Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller (BET). The static adsorption experiment was carried out to investigate the adsorption properties. The results indicated that pH 4 was best for the adsorption removal of RB-19 in the pH range of 4–9. Compared with the pseudo-first-order model and Elovich model, the pseudo-second-order equation was best to describe the adsorption process (R² > 0.995). The Langmuir model was better than the Freundlich model to fit the experimental data (R² > 0.990). The intra-particle diffusion model showed that film diffusion and intra-particle diffusion were involved in the adsorption process. Thermodynamic parameters showed that the RB-19 adsorption by MBC was spontaneous and endothermic. The adsorption mechanism might include electrostatic interaction, pore filling, and hydrogen bond, and the MBC was a promising adsorbent.     

An Infectious Disease Model With Media Coverage and Limited Medical Resources北大核心CSCD

该文建立和分析了一类具有媒体报道效应和有限医疗资源的传染病动力学模型,定义了疾病的基本再生数,分析了平衡点的存在性和稳定性,给出了系统发生前向分支、后向分支和Hopf分支的条件.通过数值模拟发现：提高媒体报道的信息覆盖率或医院对病人的最大容纳量,可以显著降低疾病流行的峰值或稳态时的感染人数;随着参数变化,系统不仅可能会产生后向分支或前向分支,还可能会出现鞍结点分支、Hopf分支以及地方病平衡点稳定性随参数变化而变化等动力学行为.     

基于慢性病诊疗实践的参与式社区医生培训效果评价

目的 了解社区医生慢性病的诊疗知识水平,并对基于常见慢性病诊疗实践的交互式小组培训模式的效果进行评 价。方法 2013年7 月～2014年6月,对义乌市13家社区卫生服务中心的194名社区卫生服务中心一线工作人员及社区卫生服务站的责任医师进行慢性病诊疗知识问卷调查,并实施小班化互动式“二组二段式”新型培训模式,对培训效果进行评价。结果 （1）社区医生慢性病综合防治及社区管理能力水平较低,接受新型培训模式的医生慢性病危险因素知识及社区综合管理知识的平均答对率由31.8%提高到59. 0%（P＜0.01）。（2）接受新型培训模式的医生对高血压病、糖尿病和冠心病规范化诊疗水平、康复知识及社区管理知识的平均总分在培训前后均显著提高（P＜0.01）。结论 “以问题为中心,以病例为引导”的“二组二段式”小班化互动式新型社区医生慢性病规范化诊疗知识的培训模式简单实用,明显提高社区医师对慢性病的诊疗水平,可在社区医院或基层培训机构全面推广。     

2012年CUMCM A 题解答评析

根据评卷过程中收集到的信息对2012年全国大学生数学建模竞赛的“葡萄酒的评价”问题进行分析,展示了一些较好的模型和结果,并针对答卷中反映的问题提出一些建议。