Effects of Citicoline,Homotaurine, and Vitamin E on Contrast Sensitivity and Visual-Related Quality of Life in Patients with Primary Open-Angle Glaucoma: A Preliminary Study

The aim of the present study was to evaluate the effects of supplementation with a fixed combination of citicoline 500 mg, homotaurine 50 mg, and vitamin E 12 mg (CIT/HOMO/VITE) on contrast sensitivity and visual-related quality of life in patients with primary open-angle glaucoma (POAG) in mild stage. This was a multicenter, observational, cross-over, short-term, pilot study on POAG patients with stable controlled intraocular pressure (IOP). Patients were randomly assigned to Group 1 (current topical therapy for 4 months and then current topical therapy plus CIT/HOMO/VITE for 4 months) or Group 2 (CIT/HOMO/VITE in addition to current topical therapy for 4 months and then topical therapy alone for 4 months). Best-corrected visual acuity, IOP, visual field, and the Spaeth/Richman contrast sensitivity (SPARCS) test score were recorded at baseline and after 4 and 8 months. The Glaucoma Quality of Life-15 (GQL-15) questionnaire was administered at each check time. Forty-four patients were assigned to Group 1 and 65 to Group 2. Over the follow-up period, there were no significant changes in IOP or visual field findings, whereas SPARCS and GQL-15 findings significantly varied from baseline, both being improved in subjects treated with CIT/HOMO/VITE fixed combination. These results demonstrate that a daily intake of a fixed combination of citicoline, homotaurine, and vitamin E in addition to the topical medical treatment significantly increased the total score of the contrast sensitivity test and the quality of life in patients with POAG.     

回归分析在殷墟墓葬分期中的应用

数理统计方法，在我国考古学中的应用，目前处于探索、研究阶段。本文试用回归方法，建立殷墟墓葬分期的多元线性回归模型，并确定出墓葬分期的预测区间。     

Mössbauer and ERS evidence of hemocromes in neoplastic pathologies

Summary Red blood cells collected from patients with leukaemia and breast cancer have been investigated with M?ssbauer spectroscopy. A component not usually present in red cells has been analysed. The M?ssbauer parameters, also supported by electron spin resonance measurements, suggest that they can be assigned to a hemocrome. This work was supported by Ministero Pubblica Istruzione and Italian National Research Council.     

再谈核磁共振在医学方面的应用

阐述了核磁共振的本质，论述了其在医学领域的应用及前景。     

新疆三类药用昆虫的资源状况及应用前景的预测

对新疆三类药用昆虫－芫菁、地鳖和蝉的研究表明，在已知的４１种芫菁中，有１１种种群数量较大，资源较为丰富，地鳖１种－黑冀地鳖和６种蝉类中的赭斑蝉资源亦佳，通过对三类药用昆虫药用有效成分的测定，亦证明具有良好的应用前景。     

Laser ablation parameters of atherosclerotic arteries

Summary The threshold of atherosclerotic plaque ablation in water by the XeCl laser radiation was measured to be of (1.5±0.2) J/cm². Within the simple thermal model this value corresponds to the mean temperature of about 373 K in the irradiated volume as for other angioplasty lasers. Time-of-flight probing of ablation in air by the XeCl and CO₂ lasers revealed microsecond lifetimes of ablated volumes that confirm the mechanism of explosive boiling of superheated tissue water. So the local temperature must be about 582 K which can be due to inhomogeneous light distribution and absorption. The short lifetime leads to the absence of heat diffusion and, hence, to the ablative character of tissue destruction.     

非接触二次色散法测量人体血糖的初步研究

提出了一种测量血糖浓度的新方法——二次色散法，此方法采用低相干干涉仪来测量时间相干干涉信号，通过傅里叶变换和多项式拟合获得二次色散。初步测量了三种不同浓度的糖溶液在0．55μm到0．8μm之间的二次色散，实验结果发现随着血糖浓度的增加，二次色散也随之增加。研究证明该方法是一种潜在的无接触、无伤害在线探测人体血糖浓度的方法。为设计一种非接触、无伤害在线探测人体血糖浓度的光学医疗仪器奠定基础。最后讨论了采用本方法尚需改进的问题和进一步的工作。     

Validation of two analytical methods for the determination of ochratoxin A by reversed-phased high-performance liquid chromatography coupled to fluorescence detection in musts and sweet wines from Andalusia

Some Spanish sweet wines are made from raisins, grapes dried by direct exposure to the sun after picking. This drying process can encourage ochratoxin A (OTA) formation. OTA is a mycotoxin formed by several fungi. It has been linked to nephropathy in humans, and may have a long half-life in humans. The aim of this study is to develop and to apply two procedures for the analysis of OTA in grape musts (during the raisining process) and sweet wines, respectively. Reversed-phase high-performance liquid chromatography (RP-HPLC) coupled to fluorescence detection (FLD) was employed in both analytical methods. In grape must, the method involves the direct injection of the sample in a HPLC-FLD system without any kind of prior clean-up procedure. The complexity of the sweet wine samples requires a solid-phase extraction (SPE) clean-up on a C18 column which enables the OTA to be isolated from the matrix. The methods used were statistically validated. The validation also included the comparison of the slopes of the curve obtained with standards and the regression curves obtained by the addition of a standard. Two different studies of standard additions were conducted. One method was validated without sample preparation and it was applied to must samples. The other method was validated with SPE extraction and it was applied to sweet wine samples. Recovery was always better than 89.69%. The limit of detection (S/N = 3) and limit of quantification (S/N = 10) were established at 0.22 and 0.77 μg l⁻¹, respectively. In general, the analytical data obtained provided good results at the sub-μg l⁻¹ concentration level.     

Radiation‐induced migration of additives in PVC‐based biomedical disposable devices Part 2. Surface analysis by XPS

Extruded parts of non‐sterilized and β‐irradiated (25 and 50 kGy) plasticized poly(vinyl chloride) (PVC) used for disposable medical devices have been studied to investigate the effect of sterilization on surface chemical composition. The polymer surfaces were analysed using angle‐resolved x‐ray photoelectron spectroscopy. The inner surface of the blood tubing lines showed a fairly smooth surface both before and after sterilization, so a laterally homogeneous surface can be assumed for XPS analysis. The XPS survey spectra exhibited no signals besides carbon, chlorine, oxygen and calcium. Detailed analysis of the regions showed the C 1s, Cl 2p and O 1s signals to be multi‐component, presenting signals of the PVC, the plasticizer and the other additives. Binding energies remained constant irrespective of β‐radiation dosage, but the amount of chlorine component at 198.4 ± 0.1 eV (associated with modified PVC) decreased with sterilization dosage. Angle‐resolved XPS revealed that this component is located at the outermost surface of the polymer. It can be hypothesized that the production processes themselves (extrusion and/or injection molded) already induce modifications of the polymer surface and also lead to surface segregation of the plasticizer. During the subsequent thermal sterilization of the polymer dehydrochlorination continues but, because of the very short time required by the β‐irradiation technology to sterilize devices, the atmospheric oxygen is unable to diffuse into the irradiated material, thus inhibiting further side‐degradation of the materials, such as thermo‐oxidative degradation. Copyright © 2003 John Wiley & Sons, Ltd.