皮肤毛孔照片诊断标准评价的潜在分类变量模型研究

本文在无金标准情况下探讨皮肤毛孔标准照片制定的合理性和可行性,对医师诊断正确性进行评价。按照毛孔粗大程度制定分类为5水平的毛孔标准照片。对128名女性志愿者制作鼻翼毛孔照片,5位年资相近的皮肤科医师按照诊断标准和标准照片对128例自愿者照片进行独立的等级评分。诊断结果数据采用潜在分类变量模型(Latent Class Model,LCM)进行分析,分别拟合5位医师诊断条件概率一致的模型和诊断条件概率不一致的模型。计算医师诊断的条件概率和后验概率。潜变量分析结果提示诊断标准过于细化且分类模糊,依据条件概率将原始分类重新划分为3类的模型较好地拟合了诊断数据。运用客观和准确的能够真实反应和区分个体情况的诊断标准是诊断试验评价的基础和前提。潜在分类模型能够有效地处理无金标准的诊断重复性或一致性研究数据。     

Two positivity preserving flux limited,second‐order numerical methods for a haptotaxis model

Two numerical methods for a one‐dimensional haptotaxis model, which exploit the use of van Leer flux limiter, are developed and analyzed. Sufficient conditions time step size and flux limiting are given for such formulation to ensure the non‐negativity of the discrete solution and second‐order accuracy in space. Another advantage is that we avoid solving large nonlinear systems of algebraic equations. The discrete preservation of total conservation of cell density, concentration, and logarithmic density is also verified for the numerical solution. Numerical results concerning accuracy, convergence rate, positivity, and conservation properties are presented and discussed. Similar approach could be applied efficiently in the corresponding two‐ and three‐dimensional problems. © 2012 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2013     

Structural singularities of the Eu2+-doped spatially coherent [KBr0.097I0.903](0.348):[KBr0.459Cl0.511I0.030](0.652) composite as seen under the epifluorescence optical microscopy

Large crystal growths of the Eu²⁺-doped spatially coherent [KBr_0.097I_0.903](0.348):[KBr_0.459Cl_0.511I_0.030](0.652) composite were characterized by X-ray diffraction and then studied by epifluorescence optical microscopy. Doping Eu²⁺ ions were observed to prefer sites located at certain linear structural singularities of the composite matrix to be segregated at. These singularities (2.1?×?10⁷?singularities?cm^?2), identified as crystal lattice dislocations, were found to be distributed within the composite matrix so that they form periodic arrays of linear structural singularities (1.8?×?10⁴?singularities?cm^?1). These arrays, identified as grain sub-boundaries, were found to envelope individual structural domains (1–5?µm in size) of either KBr_0.459Cl_0.511I_0.030:Eu²⁺ or KBr_0.097I_0.903:Eu²⁺. These domains were found to aggregate among themselves to form the whole composite building. Small misfit angles (e.g. 7′?±?1′ and 10′?±?1′) characterize homo-phase structural domains while large misfit angles are characteristic of hetero-phase structural domains. Crystal lattice dislocations, forming the grain sub-boundaries, were found to present, as structural features, kinks and bifurcation points. The spatial configurations adopted by two of these features are carefully described.     

Theoretical studies of Ir5Th and Ir5Ce nanoscale precipitates in Ir

Experimentally, it is known that very small amounts of thorium and/or cerium added to iridium metal form a precipitate, Ir₅Th/Ir₅Ce, which improves the high-temperature mechanical properties of the resulting alloys. We demonstrate that there are low-energy configurations for nanoscale precipitates of these phases in Ir, and that these coherent arrangements may assist in producing improved mechanical properties. One precipitate/matrix orientation gives a particularly low interfacial energy, and a low lattice misfit. Nanolayer precipitates with this orientation are found to be likely to form with little driving force to coarsen. The predicted morphology of the precipitates and their orientation with the matrix phase provide a potential experiment that could be used to test these predictions.     

Effect of solute atoms on fracture toughness in dilute magnesium alloys

The effect of alloying elements on the toughness and the fracture behaviour was investigated on seven kinds of Mg-0.3?at.% X (X?=?Ag, Al, Ca, Pb, Sn, Y and Zn) alloys with a grain size of 3–5?μm. The fracture toughness and fracture behaviour in magnesium alloys were closely related to the segregation energy. The Mg–Al and –Zn alloys that had small segregation energy showed high toughness and ductile fracture in most regions, while the Mg–Ca alloy with large segregation energy exhibited low toughness and intergranular fracture. These different tendencies resulted from solute segregation at grain boundaries (GBs). The change in the lattice parameter ratio was the influential material parameter regardless of whether the GB embrittlement was for enhancement or suppression.     

Significant decrease in interfacial energy of grain boundary through serrated grain boundary transition

The mechanism of serrated grain boundary formation and its effect on liquation behaviour have been studied in a wrought nickel-based superalloy – Alloy 263. It was newly discovered that grain boundaries are considerably serrated in the absence of γ?′-phase or M₂₃C₆ at the grain boundaries. An electron energy-loss spectroscopy study suggests that serration is triggered by the discontinuous segregation of C and Cr atoms at grain boundaries for the purpose of relieving the excessive elastic strain energy. The grain boundaries serrate to have specific segments approaching one {111} low-index plane at a boundary so that the interfacial free energy of the grain boundary can be decreased, which may be responsible for the driving force of the serration. The serrated grain boundaries effectively suppress grain coarsening and are highly resistant to liquation due to their lower wettability resulting from a lower interfacial energy of the grain boundary.     

Elastic mechanical grain interactions in polycrystalline materials; analysis by diffraction-line broadening

Abstract

Experimental investigations have revealed that the Neerfeld–Hill and Eshelby–Kröner models, for grain interactions in massive, bulk (in particular, macroscopically isotropic) polycrystals, and a recently proposed effective grain-interaction model for macroscopically anisotropic polycrystals, as thin films, provide good estimates for the macroscopic (mechanical and) X-ray elastic constants and stress factors of such polycrystalline aggregates. These models can also be used to calculate the strain variation among the diffracting crystallites, i.e. the diffraction-line broadening induced by elastic grain interactions can thus be predicted. This work provides an assessment of diffraction-line broadening induced by elastic loading of polycrystalline specimens according to the various grain-interaction models. It is shown that the variety of environment, and thus the heterogeneity of the stress–strain states experienced by each of the individual grains exhibiting the same crystallographic orientation in a real polycrystal, cannot be accounted for by traditional grain-interaction models, where all grains of the same crystallographic orientation in the specimen frame of reference are considered to experience the same stress–strain state. A significant degree of broadening which is induced by the heterogeneity of the environments of the individual crystallites is calculated on the basis of a finite element algorithm. The obtained results have vast implication for diffraction-line broadening analysis and modelling of the elastic behaviour of massive polycrystals.