A panel of three lipid-modified, functionalized biphenyl cross-linkers (fBph) were synthesized and subsequently employed in the preparation of the stapled oxyntomodulin (OXM) analogs. In a luciferase-based reporter assay, these stapled OXM analogs showed varying degree of potency in activating GLP-1R and GCGR, presumably due to the disparate effect of the lipid chains on the local environment close to the ligand-receptor binding interface. In particular, the fBph-1 cross-linked peptide with the lipid chain attached to position-3 of the biphenyl cross-linker exhibited the highest dual agonist activity. 相似文献
Polymer particle growth in catalytic ethylene slurry polymerizations with SiO2‐supported metallocene and post‐metallocene catalysts was monitored online using a Lasentec FBRM probe inserted into the stirred reactor. FBRM enabled the online monitoring of particle numbers and size distributions. Trend analyses provided time‐resolved information on selected variables of the particle growth processes. FBRM was combined with simultaneous ethylene mass flow measurements in order to distinguish between ideal particle growth and more complex growth processes involving particle fragmentation and aggregation. Additional use of a Lasentec PVM video microscopy probe during ethylene polymerization on a MgCl2‐supported Ziegler catalyst enabled the online visualization of PE particles, complementing the data generated by FBRM online monitoring.
The fractional multi time Lagrangian equations has been derived for dynamical systems within Riemann-Liouville derivatives. The
fractional multi time Hamiltonian is introduced as Legendre transformation of multi time Lagrangian. The corresponding fractional
Euler-Lagrange and the Hamilton equations are obtained and the fractional multi time constant of motion are discussed. 相似文献