空气中单个激光等离子体通道的形成条件

利用皮秒和飞秒激光研究了激光在空气中聚焦产生单个等离子体通道的条件.研究发现，能量为8—12mJ皮秒激光被焦距为15cm的透镜聚焦后，可以产生较为稳定的单个通道.通过横向纵向阴影成像分析发现，通道的管壁对聚焦产生的自发光具有箍缩作用，而通道内部却有利于光的传输.同时还发现，当采用短焦距透镜时，能量低于10mJ的飞秒激光在空气中较易形成单个等离子通道. 关键词： 等离子体通道 皮秒激光 飞秒激光 阴影成像     

Epithelial Sodium Channel Inhibition by Amiloride Addressed with THz Spectroscopy and Molecular Modeling

THz spectroscopy is important for the study of ion channels because it directly addresses the low frequency collective motions relevant for their function. Here we used THz spectroscopy to investigate the inhibition of the epithelial sodium channel (ENaC) by its specific blocker, amiloride. Experiments were performed on A6 cells’ suspensions, which are cells overexpressing ENaC derived from Xenopus laevis kidney. THz spectra were investigated with or without amiloride. When ENaC was inhibited by amiloride, a substantial increase in THz absorption was noticed. Molecular modeling methods were used to explain the observed spectroscopic differences. THz spectra were simulated using the structural models of ENaC and ENaC—amiloride complexes built here. The agreement between the experiment and the simulations allowed us to validate the structural models and to describe the amiloride dynamics inside the channel pore. The amiloride binding site validated using THz spectroscopy agrees with previous mutagenesis studies. Altogether, our results show that THz spectroscopy can be successfully used to discriminate between native and inhibited ENaC channels and to characterize the dynamics of channels in the presence of their specific antagonist.     

复合吸附剂SiO2·xH2O·yCaCl2的水蒸气吸附等温线

配制了一种由粗孔球形硅胶和氯化钙组成的新型复合吸附剂SiO2·xH2O·yCaCl2,测得了4个不同氯化钙含量的复合吸附剂样品(氯化钙质量分数分别为0.130,0.2733,0.384和0.510)、CaCl2和粗孔球形硅胶在25℃、35℃及45℃的水蒸气吸附等温线。实验结果表明,复合吸附剂的平衡吸水量随CaCl2质量分数增加而增加,最大可达到粗孔球形硅胶的10倍。用Dubinin-Astakhov方程回归测得的等温线,求得相应的参数。     

空气耦合超声检测复合材料研究综述*

复合材料普遍具有高比强度、高比刚度、高模量、耐腐蚀等优异性能,广泛应用于飞机机翼、导弹外壳、航空发动机壳体等部位。制造和服役过程中各类缺陷影响复合材料的力学性能和服役性能,必须采用有效的方法准确检测和评估复合材料中各类缺陷。空气耦合式超声检测具有完全非接触、非侵入、无损伤和无需耦合剂的特点,能够很好地运用于复合材料的在线和在位检测。该文就近年来空气耦合超声检测技术的研究现状进行了系统综述,简明扼要地分析和介绍了当前空气耦合超声检测的研究热点及进展,重点介绍了1-3型压电复合材料换能器、信号处理技术、相控聚焦式空气耦合超声检测、超声在复合材料的传播特性及其与缺陷交互作用的研究现状,探讨了空气耦合超声无损检测技术与仪器的发展方向,总结了目前空气耦合超声检测的研究热点问题,最后展望了空气耦合超声检测的发展趋势和应用前景。     

利用部分纠缠的特殊二粒子W态和部分纠缠的二粒子态传送二粒子纠缠态

提出了利用部分纠缠的特殊二粒子W态和部分纠缠的二粒子态组成量子信道,隐形传送一个二粒子纠缠态的方案。发送者进行两次Bell基测量,接受者先在{|0〉,|1〉}基下进行一次测量,然后实施一次控制—非操作,最后引进一个辅助粒子并进行一组适当的幺正变换操作,便可以一定的概率实现二粒子纠缠态的隐形传送。分析表明:当量子信道处于最大纠缠,即信道由一个特殊二粒子W态和一个Bell态组成时,本方案的传输概率达到2/3,传输效果介于完全由W态组成量子信道与完全由Bell态组成量子信道的方案之间。     

GC–MS Analysis and In Vivo and Ex Vivo Antidiarrheal and Antispasmodic Effects of the Methanolic Extract of Acacia nilotica

This present study evaluated and rationalized the medicinal use of the fruit part of Acacia nilotica methanolic extract. The phytochemicals were detected using gas chromatography–mass spectrometry (GC–MS) while the in vivo antidiarrheal test was done using Swiss albino mice. To determine the details of the mechanism(s) involved in the antispasmodic effect, isolated rat ileum was chosen using different ex vivo assays by maintaining a physiological environment. GC–MS results showed that A. nilotica contained pyrogallol as the major polyphenol present (64.04%) in addition to polysaccharides, polyphenol, amino acid, steroids, fatty acid esters, and triterpenoids. In the antidiarrheal experiment, A. nilotica inhibited diarrheal episodes in mice significantly (p < 0.05) by 40% protection of mice at 200 mg/kg, while 80% protection was observed at 400 mg/kg by the orally administered extract. The highest antidiarrheal effect was observed with loperamide (p < 0.01), used as a control drug. In the ex vivo experiments, A. nilotica inhibited completely in increasing concentrations (0.3 to 10 mg/mL) the carbachol (CCh; 1 µM) and high K⁺ (80 mM)-evoked spasms in ileum tissues at equal potencies (p > 0.05), similar to papaverine, a dual inhibitor of the phosphodiesterase enzyme (PDE) and Ca⁺⁺ channels. The dual inhibitory-like effects of A. nilotica on PDE and Ca⁺⁺ were further validated when A. nilotica extract (1 and 3 mg/mL)-pre-incubated ileum tissues potentiated and shifted isoprenaline relaxation curves towards lower doses (leftward), similar to papaverine, thus confirming the PDE inhibitory-like mechanism whereas its CCB-like effect of the extract was confirmed at 3 and 5 mg/mL by non-specific inhibition of CaCl₂-mediated concentration response curves towards the right with suppression of the maximum peaks, similar to verapamil, used as standard CCB. Thus, this study characterized the chemical composition and provides mechanistic support for medicinal use of A. nilotica in diarrheal and hyperactive gut motility disorders.     

In Silico and Ex Vivo Studies on the Spasmolytic Activities of Fenchone Using Isolated Guinea Pig Trachea

Fenchone is a bicyclic monoterpene found in a variety of aromatic plants, including Foeniculum vulgare and Peumus boldus, and is used in the management of airways disorders. This study aimed to explore the bronchodilator effect of fenchone using guinea pig tracheal muscles as an ex vivo model and in silico studies. A concentration-mediated tracheal relaxant effect of fenchone was evaluated using isolated guinea pig trachea mounted in an organ bath provided with physiological conditions. Sustained contractions were achieved using low K⁺ (25 mM), high K⁺ (80 mM), and carbamylcholine (CCh; 1 µM), and fenchone inhibitory concentration–response curves (CRCs) were obtained against these contractions. Fenchone selectively inhibited with higher potency contractions evoked by low K⁺ compared to high K⁺ with resultant EC₅₀ values of 0.62 mg/mL (0.58–0.72; n = 5) and 6.44 mg/mL (5.86–7.32; n = 5), respectively. Verapamil (VRP) inhibited both low and high K⁺ contractions at similar concentrations. Pre-incubation of the tracheal tissues with K⁺ channel blockers such as glibenclamide (Gb), 4-aminopyridine (4-AP), and tetraethylammonium (TEA) significantly shifted the inhibitory CRCs of fenchone to the right towards higher doses. Fenchone also inhibited CCh-mediated contractions at comparable potency to its effect against high K⁺ [6.28 mg/mL (5.88–6.42, n = 4); CCh] and [6.44 mg/mL (5.86–7.32; n = 5); high K⁺]. A similar pattern was obtained with papaverine (PPV), a phosphodiesterase (PDE), and Ca²⁺ inhibitor which inhibited both CCh and high K⁺ at similar concentrations [10.46 µM (9.82–11.22, n = 4); CCh] and [10.28 µM (9.18–11.36; n = 5); high K⁺]. However, verapamil, a standard Ca²⁺ channel blocker, showed selectively higher potency against high K⁺ compared to CCh-mediated contractions with respective EC₅₀ values of 0.84 mg/mL (0.82–0.96; n = 5) 14.46 mg/mL (12.24–16.38, n = 4). The PDE-inhibitory action of fenchone was further confirmed when its pre-incubation at 3 and 5 mg/mL potentiated and shifted the isoprenaline inhibitory CRCs towards the left, similar to papaverine, whereas the Ca²⁺ inhibitory-like action of fenchone pretreated tracheal tissues were authenticated by the rightward shift of Ca²⁺ CRCs with suppression of maximum response, similar to verapamil, a standard Ca²⁺ channel blocker. Fenchone showed a spasmolytic effect in isolated trachea mediated predominantly by K⁺ channel activation followed by dual inhibition of PDE and Ca²⁺ channels. Further in silico molecular docking studies provided the insight for binding of fenchone with Ca²⁺ channel (−5.3 kcal/mol) and K⁺ channel (−5.7), which also endorsed the idea of dual inhibition.     

Non-Reconciled Physical-Layer Keys-Assisted Secure Communication Scheme Based on Channel Correlation

Physical-layer key generation technology requires information reconciliation to correct channel estimation errors between two legitimate users. However, sending the reconciliation signals over the public channel increases the communication overhead and the risk of information leakage. Aiming at the problem, integrated secure communication schemes using non-reconciled keys have attracted extensive attention. These schemes exploit channel coding to correct both inconsistent keys and transmission error bits. Meanwhile, more redundant code bits must be added to correct errors, which results in a lower secure transmission rate. To address the problem, we analyze the merit of channel correlation between non-reconciled key generation and secure transmission. Inspired by this, we propose a non-reconciled physical-layer keys-assisted secure communication scheme based on channel correlation. First of all, the signal frame is designed to make use of channel correlation between non-reconciled key generation and secure transmission. Based on the channel correlation, non-reconciled keys are then generated from the wireless channel to encrypt transmitted data. Moreover, an adaptive coding algorithm based on the equivalent channel is presented to encode the data bits before encryption, to guarantee reliable transmission. Finally, theoretical analysis and simulations demonstrate the significant performance of the proposed scheme in terms of low bit error ratio and high secure transmission rate.     

A Novel Deep Transfer Learning Method for Intelligent Fault Diagnosis Based on Variational Mode Decomposition and Efficient Channel Attention

In recent years, deep learning has been applied to intelligent fault diagnosis and has achieved great success. However, the fault diagnosis method of deep learning assumes that the training dataset and the test dataset are obtained under the same operating conditions. This condition can hardly be met in real application scenarios. Additionally, signal preprocessing technology also has an important influence on intelligent fault diagnosis. How to effectively relate signal preprocessing to a transfer diagnostic model is a challenge. To solve the above problems, we propose a novel deep transfer learning method for intelligent fault diagnosis based on Variational Mode Decomposition (VMD) and Efficient Channel Attention (ECA). In the proposed method, the VMD adaptively matches the optimal center frequency and finite bandwidth of each mode to achieve effective separation of signals. To fuse the mode features more effectively after VMD decomposition, ECA is used to learn channel attention. The experimental results show that the proposed signal preprocessing and feature fusion module can increase the accuracy and generality of the transfer diagnostic model. Moreover, we comprehensively analyze and compare our method with state-of-the-art methods at different noise levels, and the results show that our proposed method has better robustness and generalization performance.