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121.
In this paper, we address the problem of planning the patient flow in hospitals subject to scarce medical resources with the objective of maximizing the contribution margin. We assume that we can classify a large enough percentage of elective patients according to their diagnosis-related group (DRG) and clinical pathway. The clinical pathway defines the procedures (such as different types of diagnostic activities and surgery) as well as the sequence in which they have to be applied to the patient. The decision is then on which day each procedure of each patient’s clinical pathway should be done, taking into account the sequence of procedures as well as scarce clinical resources, such that the contribution margin of all patients is maximized. We develop two mixed-integer programs (MIP) for this problem which are embedded in a static and a rolling horizon planning approach. Computational results on real-world data show that employing the MIPs leads to a significant improvement of the contribution margin compared to the contribution margin obtained by employing the planning approach currently practiced. Furthermore, we show that the time between admission and surgery is significantly reduced by applying our models. 相似文献
122.
Recent developments in microbial inulinases 总被引:15,自引:0,他引:15
Ashok Pandey Carlos R. Soccol Ponniah Selvakumar Vanete T. Soccol Nadia Krieger Jose D. Fontana 《Applied biochemistry and biotechnology》1999,81(1):35-52
Microbial inulinases are an important class of industrial enzymes that have gained much attention recently. Inulinases can
be produced by a host of microorganisms, including fungi, yeast, and bacteria. Among them, however, Aspergillus sp. (filamentous fungus) and Kluyveromyces sp. (diploid yeast) are apparently the preferred choices for commercial applications. Among various substrates (carbon source)
employed for their production, inulin-containing plant materials offer advantages in comparison to pure substrates. Although
submerged fermentation has been universally used as the technique of fermentation, attempts are being made to develop solidstate
fermentation technology also. Inulinases catalyze the hydrolysis of inulin to d-fructose (fructose syrup), which has gained an important place in human diets today. In addition, inulinases are finding
other newer applications. This article reviews more recent developments, especially those made in the past decade, on microbial
inulinases—its production using various microorganisms and substrates. It also describes the characteristics of various forms
of inulinases produced as well as their applications. 相似文献
123.
Muhammad Zaheer Afzal Shah Zareen Akhter Rumana Qureshi Bushra Mirza Misbah Tauseef Michael Bolte 《应用有机金属化学》2011,25(1):61-69
Synthesis of ferrocenyl Schiff bases ( 1–6 ) was carried out by the condensation reaction of 4‐ferrocenyl aniline with different substituted aromatic aldehydes and acetyl acetone. Compounds were characterized by physical measurements, elemental analysis, FT‐IR, 1H‐NMR and 13C‐NMR spectroscopy. Single crystal X‐ray analysis of compound 2 showed the co‐planarity of both aromatic rings connected by a C–N double bond. Compounds demonstrated reversible one‐electron redox behavior and their peak currents were found to increase linearly with the square root of the sweep rate ν1/2. The overall electrode processes were found to be diffusion controlled. Compounds 1 and 4 showed low cytotoxicity and appreciable antifungal, antioxidant and DNA protection activities. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
124.
D. Zappe 《Isotopes in environmental and health studies》2013,49(7):272-274
Investigations made into a gas-solid-fluidized bed model reactor, aiming at obtaining statements about the spatial and time density distributions within the fluidized bed and the correlation between the state of the turbulent layer and a characteristic measured quantity as well as variation of a physical property of the solid. statisticl evaluation techniques are indispensable, owing to the elementary actions occuring within the fluidized bed reactor and their random nature. Such parameters of the fluidized bed could be determined from a totality of individual measurements for measuring periods of 10 ms per single measurement by use of a miniature measuring probe within the interior of the fluidized bed reactor. This probe consisted of a beta-radition source and a Si-surface barrier-layer detector. 相似文献
125.
Clinical microdialysis (MD) is a minimally invasive sampling technique that offers selective in-vivo measurement of free, active drug or biomolecule concentrations in human tissues and organs. From a regulatory perspective, MD can thus be seen as a suitable scientific tool that meets regulatory requirements for the study of tissue distribution or bioequivalence during drug development. From a clinical perspective, the use of MD in different applications has shown the potential to rationalize drug-dosing regimens and to influence clinical decision-making, although validation and correlation of MD-derived results with clinical response are required to promote routine clinical use of the technique. From an analytical perspective, highly sensitive analytical systems have increasingly become available for MD-sample analysis, and these have further improved the quality and the power of MD-derived information. Given the constant development in recent years, MD data might become an important part of new drug submissions and clinical treatment algorithms, and might positively influence patient benefit in the future. 相似文献
126.
János D. Pintér 《Journal of Global Optimization》2007,38(1):79-101
The Lipschitz Global Optimizer (LGO) software integrates global and local scope search methods, to handle a very general class
of nonlinear optimization models. Here we discuss the LGO implementation linked to the General Algebraic Modeling System (GAMS).
First we review the key features and basic usage of the GAMS /LGO solver option, then present reproducible numerical results
to illustrate its performance. 相似文献
127.
S. Lorenzo-Freire J.M. Alonso-Meijide B. Casas-Méndez M.G. Fiestras-Janeiro 《European Journal of Operational Research》2007
In this paper, we provide a new characterization of the Deegan–Packel power index, which uses a new monotonicity property, and two characterizations of the Johnston power index by employing some usual properties of the literature and two new transfer properties. Finally, a real-world numerical example taken from the political field illustrates the main differences between these two indices. 相似文献
128.
R. Wilfinger J. Lettry A. Fabich H. Aiginger K. Poljanc R. Catherall M. Eller 《The European physical journal. Special topics》2007,150(1):373-378
Thermal stress-waves are generated in the solid target
material when the proton beam interacts. These stress waves excite
natural oscillations of the target or cause plastic deformations.
Hence, an experimental setup with a laser Doppler vibrometer
[CITE] was developed to investigate free surface
vibrations of cylindrical targets. The target configurations for
RIB and conventional neutrino beams (CNGS project) were
investigated to analyze proton induced thermal stress-wave
generation and propagation. 相似文献
129.
光谱痕量分析的检出限问题 总被引:2,自引:0,他引:2
陈远盘 《光谱学与光谱分析》1994,14(5):105-110
本文研究了光谱分析中的检出限问题。对目前文献中提出的一些检出限的公式进行了归纳和推导。讨论了IUPAC和Long检出限公式的一些实际应用。 相似文献
130.
In this review article, the development of the double cladding optical fiber for high power fiber lasers is reviewed. The
main technology for high power fiber lasers, including laser diode beam shaping, fiber laser pumping techniques, and amplification
systems, are discussed in detail. 1050 W CW output and 133 W pulsed output are obtained in Shanghai Institute of Optics and
Fine Mechanics, China. Finally, the applications of fiber lasers in industry are also reviewed.
相似文献