Chloroaluminate Ionic Liquid Immobilized on Magnetic Nanoparticles as a Heterogeneous Lewis Acidic Catalyst for the Friedel–Crafts Sulfonylation of Aromatic Compounds

Chloroaluminate ionic liquid bound on magnetic nanoparticles (Fe₃O₄@O₂Si[PrMIM]Cl·AlCl₃) was prepared and used as a heterogenous Lewis acidic catalyst for the Friedel–Crafts sulfonylation of aromatic compounds with sulfonyl chlorides or p-toluenesulfonic anhydride. The catalyst’s stability, efficiency, easy recovery, and high recyclability without considerable loss of catalytic capability after four recycles were evidence of its advantages. Furthermore, the stoichiometry, wide substrate scope, short reaction time, high yield of sulfones, and solvent-free reaction condition also made this procedure practical, ecofriendly, and economical.     

Trifluoroethanol Promoted Castagnoli–Cushman Cycloadditions of Imines with Homophthalic Anhydride

Lactams are essential compounds in medicinal chemistry and key intermediates in the synthesis of natural products. The Castagnoli–Cushman reaction (CCR) of homophthalic anhydride with imines is an exciting method for accessing cyclic densely substituted lactam products. Most CCRs need to be catalyzed or heated. Herein, we report a new, efficient, metal and catalyst-free CCR for the synthesis of poly-substituted 3,4-lactams utilizing the unique properties of trifluoroethanol (TFE). This procedure provides high-speed and smooth access to a broad range of densely substituted 3,4-lactams in good yields and a 100% atom-economical fashion.     

Chemical modification of E. coli L-asparaginase with polyethylene glycol grafted vinylpyrrolidone–maleic anhydride copolymer

A series of polyethylene glycol grafted vinylpyrrolidone–maleic anhydride copolymers [P(VMP)] was synthesized by radical copolymerization of vinylpyrrolidone, maleic anhydride and polyethylene glycol maleic acid monoester. Escherichia coli l -asparaginase was chemically modified with these copolymers. The modified l -asparaginase exhibited the complete loss of antigenicity towards anti-asparaginase serum from rabbit. The highest enzyme activity of the modified l -asparaginase without antigenicity was retained by 59% of the nonmodified one. The modified enzyme was also more resistant to trypsin in vitro. When tested in vivo, the native l -asparaginase was quickly cleared from the plasma of rabbits (half-life time: t_1/2=1.2 hr), whereas the modified enzyme showed prolonged clearance from plasma (t_1/2=53 hr). © 1997 John Wiley & Sons, Ltd.     

Synthesis,polymerization, and isomerization of isoimide containing acrylate esters

Several isoimides substituted with hydroxylated substituents were prepared, and allowed to react with acryloyl chloride to form the corresponding acrylate esters. The acrylates were polymerized free radically using AIBN as the initiator yielding medium molecular weight polyacrylates. Upon warming the prepared polyacrylates or treatment with base most of the isoimide pending groups rearranged to the stable form of the corresponding imides. These rearrangements were accompanied by increase in softening points of the polymers forming thermally more stable resins. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 3125–3130, 1997     

偕二酸酯的无溶剂合成

以醛和酸酐为原料,溴化锌为催化剂,无溶剂条件下高产率地合成了偕二酸酯(其中醛与苯甲酸酐的反应是首次报道)。部分产物的结构经NMR,IR和MS表征。     

Synthesis of polyesters as binders for deinkable inks. I. Structural analysis of the polyesterification between o-phthalic anhydride and neopentyl glycol in bulk at 200°C by high resolution 13C nuclear magnetic resonance (13C-NMR)

Analysis of the polyesterification in bulk without any external catalyst at 200°C of o-phthalic anhydride with neopentyl glycol (2,2-dimethyl-1,3-propanediol) with a mole ratio ([(SINGLE BOND) COOH]/[ (SINGLE BOND) OH]) = 0.7 has been carried out by high resolution ¹³C nuclear magnetic resonance (¹³C-NMR). Polyesters can be analyzed by ¹³C-NMR spectra because of the fact that both o-phthalic acid (o-phthalic anhydride) and neopentyl glycol carbons are sensitive to sequence effects. Spin-lattice relaxation times T₁, of quaternary, tertiary and secondary carbons in different structures are in the 0.1–6.5 s range depending on the neighboring residue effects in the polymer chain. © 1996 John Wiley & Sons, Inc.     

顺丁烯二酸酐与邻苯二甲酸二甲酯二元体系在4.00, 8.00和12.00 kPa下的等压气液平衡

采用沸点仪测定了顺丁烯二酸酐和邻苯二甲酸二甲酯二元体系在4.00, 8.00和12.00 kPa下的等压气液平衡数据以及纯DMP组分饱和蒸气压数据, 将实验数据回归得到了纯DMP在417~525 K范围内的Antoine方程. 根据实验平衡温度、 压力和组成数据进一步回归得到NRTL方程参数, 推算出平衡气液相组成, 并利用UNIFAC方程对实验数据进行了预测, 其结果与沸点仪测定结果及NRTL拟合的结果基本相符.     

聚酯酸酐的合成及其药物释放性能研究

将对羟乙氧基苯甲酸分别与已二酰氯、癸二酰氯和对苯二甲酰氯反应,制备了含酯键的二羧酸.经熔融缩聚,合成了主链含酯键的新型聚酯酸酐.通过¹H NMR、IR及元素分析对单体及聚酯酸酐的结构进行了表征.研究了聚酯酸酐的体外降解和药物释放性能,其降解速率和释药速率次序为:聚4,4'-(已二酰氧二乙氧基)双对苯二甲酸＞聚4,4'-(癸二酰氧二乙氧基)双对苯二甲酸＞聚4,4'-(对苯二甲酰氧二乙氧基)双对苯二甲酸.     

N-甘氨酸基马来酰亚胺的合成研究

由于马来酸酐易发生水解反应,不能采用悬浮法和乳液法共聚而很大程度上限制了其应用。因此,合成既能克服马来酸酐缺点,又能保持其优点的可聚合单体—N-取代马来酰亚胺。N-对羧基苯基马来酰亚胺可广泛用作染料、药物以及功能高分子化合物中间体;五十岚喜雄等报道了N-取代苯马来酰亚胺类化合物具有抗微生物活性作用;环已基马来酰亚胺用于PMMA共聚改性,查显著提高PMMA的力学性能和耐热性,同时对PMMA耐候性和透光性几乎没有影响;艾娇艳H0等制备了含不对称碳原子的N-（异丙酸基）-马来酰亚胺。     

乙丙共聚物接枝马来酸酐反应机理的模拟研究

接枝反应;角鲨烷;乙丙共聚物接枝马来酸酐反应机理的模拟研究