矿物中药钟乳石的X射线衍射Fourier指纹图谱

研究矿物中药钟乳石X射线衍射Fourier指纹图谱.对10批主产地的钟乳石药材X射线衍射Fourier图谱进行分析,建立钟乳石X射线衍射Fourier指纹图谱,并通过相似度计算,区分钟乳石、其他含钙矿物中药、同种化学试剂CaCO3.主成分相同的矿物中药利用X射线衍射Fourier指纹图谱无法完全区分,但钟乳石与同种化学试剂CaCO3的X射线衍射Fourier图谱区别显著.利用X射线衍射Fourier指纹图谱可以很好的区分含有不同化学成分的矿物药,而对于主成分相同的矿物中药,就不能简单地利用它们的X射线衍射Fourier指纹图谱加以区分,即X射线衍射Fourier指纹图谱仅具有相对的专属性.     

Non-Invasive Detection of Anti-Inflammatory Bioactivity and Key Chemical Indicators of the Commercial Lanqin Oral Solution by Near Infrared Spectroscopy

Quality control methods of current traditional Chinese medicine (TCM) preparation is time-consuming and difficult to assess in terms of overall efficiency of the drug. A non-destructive rapid near-infrared spectroscopy detection system for key chemical components and biological activity of Lanqin oral solution (LOS), one of the best-selling TCM formulations, was established for comprehensive quality evaluation. Near infrared spectral scanning was carried out on 101 batches of commercial LOS under the penetrated vial state and traditional state. RAW 264.7 cells were cultured to detect the anti-inflammatory ability of LOS, and the reference concentrations of epigoitrin, geniposide, and baicalin were obtained by HPLC. The quantitative models were optimized by three kinds of variable selection methods. The correlation coefficients of prediction value of the models were greater than 0.94. The system also passed the external validation. The performance of the non-invasive models was similar to the traditional models. The established non-destructive system can be applied to the rapid quality inspection of LOS to avoid unqualified drugs from entering the market and ensure drug effectiveness. The biological activity index of LOS was introduced and predicted by NIRs for the first time, which provides a new idea about the quality control of TCM formulations.     

习近平新时代中国特色社会主义思想学理化研究论纲

加强对习近平新时代中国特色社会主义思想的学理化研究具有重大理论和现实意义。开展学理化研究,一方面是要坚持以习近平新时代中国特色社会主义思想为指导,加快推动学科体系、学术体系和话语体系建设,推动构建中国特色哲学社会科学;另一方面,学理化研究可以增强对新思想的学科体系、学术体系和话语体系的有力支撑,使新思想进一步彰显其内在的学理性、创新性和整体性,从而全面系统揭示习近平新时代中国特色社会主义思想的时代性、科学性和真理性,以及彰显当代中国马克思主义理论的优秀品质和学风文风。开展学理化研究,要紧扣习近平新时代中国特色社会主义思想这一根本性主题和主线,聚焦并挖掘新思想对马克思主义理论的原创性贡献,更好体现新思想的理论创新性、价值创造性以及实践指导性。推动学理化研究,需要处理好学理化研究与党的理论宣传和贯彻落实以及与思想性和工具性、实践性和理论性、学术话语和政策话语、本土化和国际化、学理化和大众化等之间的内在关系。     

“工作组”模式：国家治理现代化的中国经验

“工作组”作为一个广泛出现在中国政治实践中的重要现象和运作机制,在中国政治发展道路上发挥了举足轻重的作用。研究表明,“工作组”总是围绕党中央的中心任务,在不断常规化的权力运作中,提升“政党−国家”的现代化治理水平。“工作组”模式能够在实践层面联结一统体制和有效治理,在理论层面回应有关国家治理能力的讨论,从而以一种治理模式形成了国家治理现代化的中国经验。     

文学汉语实践与中国现代文学的发生

从文学汉语实践的角度探讨中国现代文学发生,即回到文学的根本基础（语言）上探讨中国现代文学的发生,把文学的发生置于语言的实践过程中思考,是最能合理且最为有效地揭示出中国现代文学发生的内部方式。文学汉语实践沿着文学汉语的汉语造型、主体意识和文学形式这三个维度展开。汉语造型指向文学汉语的“理”,实践主体指向文学汉语的“情”,文学形式指向文学汉语的“文”。汉语造型在文言与白话、汉语与欧化、标准语与方言之间改变着“理”的结构;实践主体在中国传统价值与西方现代价值以及国家、国民与个体的关系中激荡着“情”的发展;文学形式在西方文类与中国传统文类、旧体诗与新白话诗、文言文与白话文、文言小说与白话小说、晚清白话小说与新白话小说等关系中推动着“文”的演变。当“理”为现代之“理”,“情”为现代之“情”,“文”为现代之“文”,并且三者统一于文学汉语时,则实现了某种文类的新生。经过黄遵宪、严复、梁启超、林纾、章太炎、王国维和吴稚晖等作家语言实践的开拓,中国现代文学最终在胡适、鲁迅和周作人等的文学汉语实践中发生并完成。     

中药炮制机理研究的思路与方法——以咖啡豆的烘焙原理研究为例

中药炮制是中药学的特色和优势,也是最具我国自主知识产权的学科之一.中药炮制研究的核心是阐明中药炮制机理,这也是制约中药现代化的关键节点.目前大部分中药的炮制机理尚不明确,有待进行系统深入的研究.咖啡豆需要烘培后才可以制成饮料,这个高温烘培过程类似于中药的炮制过程.近年来,国内外专家对咖啡豆高温烘培过程化学成分变化及其机理进行了深入研究,各种新方法和新技术得到广泛应用,取得了系列研究成果,这些研究成果为中药炮制机理研究提供了多种新思路和新方法,也为中药炮制机理的研究和阐明提供了重要示范.     

Accelerated solvent extraction and pH‐zone‐refining counter‐current chromatographic purification of yunaconitine and 8‐deacetylyunaconitine from Aconitum vilmorinianum Kom

This study aimed to seek an efficient method to extract and purify yunaconitine and 8‐deacetylyunaconitine from Aconitum vilmorinianum Kom. by accelerated solvent extraction combined with pH‐zone‐refining counter‐current chromatography. The major extraction parameters for accelerated solvent extraction were optimized by an orthogonal test design L₉ (3)⁴. Then a separation and purification method was established using pH‐zone‐refining counter‐current chromatography with a two‐phase solvent system composed of petroleum ether/ethyl acetate/methanol/water (5:5:2:8, v/v) with 10 mM triethylamine in the upper phase and 10 mM HCl in the lower phase. From 2 g crude extract, 224 mg of 8‐deacetylyunaconitine (I) and 841 mg of yunaconitine (II) were obtained with a purity of over 98.0%. The chemical structures were identified by ESI‐MS and ¹H and ¹³C NMR spectroscopy.     

Screening of aromatase inhibitors in traditional Chinese medicines by electrophoretically mediated microanalysis in a partially filled capillary

An electrophoretically mediated microanalysis method with partial filling technique was developed for screening aromatase inhibitors in traditional Chinese medicine. The in‐capillary enzymatic reaction was performed in 20 mM sodium phosphate buffer (pH 7.4), and sodium phosphate buffer (20 mM, pH 8.0) was used as a background electrolyte. A long plug of coenzyme reduced β‐nicotinamide adenine dinucleotide 2′‐phosphate hydrate dissolved in the reaction buffer was hydrodynamically injected into a fused silica capillary followed by the injection of reaction buffer, enzyme, and substrate solution. The reaction was initiated with a voltage of 5 kV applied to the capillary for 40 s. The voltage was turned off for 20 min to increase the product amount and again turned on at a constant voltage of 20 kV to separate all the components. Direct detection was performed at 260 nm. The enzyme activity was directly assayed by measuring the peak area of the produced β‐nicotinamide adenine dinucleotide phosphate and the decreased peak area indicated the aromatase inhibition. Using the Lineweaver–Burk equation, the Michaelis–Menten constant was calculated to be 50 ± 4.5 nM. The method was applied to the screening of aromatase inhibitors from 15 natural products. Seven compounds were found to have potent AR inhibitory activity.     

Static headspace‐multicapillary column with gas chromatography coupled to ion mobility spectrometry as a simple approach for the discrimination of crude and processed traditional Chinese medicines

The processing procedure can alter the nature and chemical transformation of traditional Chinese medicine to accommodate different clinical dispensing and preparation requirements. In this study, static headspace‐multicapillary column with gas chromatography coupled to ion mobility spectrometry was developed for the rapid and sensitive discrimination of crude and processed traditional Chinese medicine. Using Radix Paeoniae Alba as a traditional Chinese medicine model, the combined power of this approach was illustrated by classifying the crude and processed Radix Paeoniae Alba samples into two main categories. The contents of the main components in Radix Paeoniae Alba varied significantly. The established method could promote the use of ion mobility spectrometry in intrinsic quality control and differentiation of herbal medicines from other processed products or preparations.     

PBL教学模式在中美高校化学实验课教学中应用的对比研究

因课程设置、学情等不同, PBL教学模式在中美高校化学实验课的实施过程中各具特色。本文从教材、课程考核、师资培训、研究机构和基金等4个角度客观分析PBL教学模式在中美2国高校化学实验课应用中的差异,并在此基础之上提出,应该客观公正地看待这种差异,树立文化自信。