全文获取类型
收费全文 | 2928篇 |
免费 | 221篇 |
国内免费 | 155篇 |
专业分类
化学 | 846篇 |
晶体学 | 15篇 |
力学 | 83篇 |
综合类 | 37篇 |
数学 | 1206篇 |
物理学 | 1117篇 |
出版年
2024年 | 5篇 |
2023年 | 39篇 |
2022年 | 102篇 |
2021年 | 109篇 |
2020年 | 84篇 |
2019年 | 100篇 |
2018年 | 86篇 |
2017年 | 117篇 |
2016年 | 144篇 |
2015年 | 87篇 |
2014年 | 181篇 |
2013年 | 244篇 |
2012年 | 190篇 |
2011年 | 202篇 |
2010年 | 158篇 |
2009年 | 192篇 |
2008年 | 195篇 |
2007年 | 137篇 |
2006年 | 133篇 |
2005年 | 111篇 |
2004年 | 88篇 |
2003年 | 85篇 |
2002年 | 82篇 |
2001年 | 48篇 |
2000年 | 50篇 |
1999年 | 53篇 |
1998年 | 49篇 |
1997年 | 28篇 |
1996年 | 26篇 |
1995年 | 20篇 |
1994年 | 17篇 |
1993年 | 16篇 |
1992年 | 12篇 |
1991年 | 19篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 10篇 |
1987年 | 8篇 |
1986年 | 8篇 |
1985年 | 15篇 |
1984年 | 9篇 |
1982年 | 6篇 |
1981年 | 10篇 |
1979年 | 6篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有3304条查询结果,搜索用时 31 毫秒
51.
Even if the first protein therapeutics are now for more than 20 years on the market the selection of suitable adsorbents for the preparative downstream processing (DSP) of these biomolecules as well as the method development towards process conditions are still based mainly on 'trial and error'. Therefore, theses processes are not perfectly efficient, but indeed very time consuming and laborious. In this study a novel systematic method is introduced to find a suitable adsorbent (not necessarily the best one) with appropriate separation parameters for a specific separation with reduced effort. Following this strategy, the adsorbents must first be packed into columns under preparative conditions and then characterized completely with regard to, e.g. pressure drop, k'-values, plate heights (HETP curves), selectivity and capacity by using test substances, which are similar in their characteristics (molecular mass, size, charge distribution, hydrophobicity) to the target proteins. With the database once determined, a preselection of most suitable adsorbents including separation parameters is made regarding chromatographic and also economical properties. After this, preparative experiments must be conducted with a reduced number of adsorbents to figure out the individual influence of side components. This approach is demonstrated for the separation of an exemplary industrial protein mixture using cation-exchange chromatography (CEX). Characterization of different weak CEX-adsorbents is illustrated. After comparing these phases with each other, a first preselection and a prediction of suitable adsorbents is made. In the following preparative separation conditions (load, velocity, gradient) are determined for the preparative separations using the database and results of some additional experiments. The final comparison of separation performance in preparative scale confirms this selection and so the applicability of the new method. 相似文献
52.
Cadmium selenide quantum dots with cubic crystal structure are chemically deposited in thin film form using selenosulfate as a precursor for selenide ions and ammonia buffer with double role: as a ligand and as a pH value controller. The optical band gap energies of as-deposited and thermally treated cadmium selenide thin films, calculated within the framework of parabolic approximation for the dispersion relation, on the basis of equations which arise from the Fermi's golden rule for electronic transitions from valence to conduction band, are 2.08 and 1.77 eV, correspondingly. The blue shift of band gap energy of 0.34 eV for as-deposited thin films with respect to the bulk value is due to the quantum size effects (i.e., nanocrystals behave as quantum dots) and this finding is in agreement with the theoretical predictions. During the thermal treatment the nanocrystals are sintered, the increase of crystal size being in correlation with the decrease of band gap energy. The annealed thin films are practically non-quantized. From the resistance-temperature measurements, on the basis of the dependence of ln(R/Ω) vs 1/T in the region of intrinsic conduction, the thermal band gap energy (at 0 K) of 1.85 eV was calculated. 相似文献
53.
54.
V.L. Furer A.E. Vandyukov J.P. Majoral A.M. Caminade V.I. Kovalenko 《Vibrational Spectroscopy》2006,40(2):155-160
The Raman (10–3500 cm−1) and infrared (150–3500 cm−1) spectra have been recorded for tris(4-oxibenzaldehyde)thiophosphate. This compound includes structural parts of elementoorganic dendrimers: a core and terminal aldehyde groups. The structural optimization and normal mode analysis are performed for elementoorganic dendrimer on the basis of the ab initio density functional theory. It is found that the dendrimer exist in a single stable conformation with planar C6H4CHO fragments. Our calculations show that conformer with one trans and two gauche 4-oxibenzaldehyde groups is realized. All these observations suggest that steric congestion does not disturb the construction of dendrimers even for the highest generations, and that terminal groups are readily available for further reactions. Relying on DFT calculations a complete vibrational assignment is proposed for different parts of the studied dendrimers. 相似文献
55.
Fu Qiang Huang 《Journal of solid state chemistry》2003,174(2):334-341
Three new compounds, Cs2Bi2ZnS5, Cs2Bi2CdS5, and Cs2Bi2MnS5, have been synthesized from the respective elements and a reactive flux Cs2S3 at 973 K. The compounds are isostructural and crystallize in a new structure type in space group Pnma of the orthorhombic system with four formula units in cells of dimensions at 153 K of a=15.763(3), b=4.0965(9), c=18.197(4) Å, V=1175.0(4) Å3 for Cs2Bi2ZnS5; a=15.817(2), b=4.1782(6), c=18.473(3) Å, V=1220.8(3) Å3 for Cs2Bi2CdS5; and a=15.830(2), b=4.1515(5), c=18.372(2) Å, V=1207.4(2) Å3 for Cs2Bi2MnS5. The structure is composed of two-dimensional ∞2[Bi2MS52−] (M=Zn, Cd, Mn) layers that stack perpendicular to the [100] axis and are separated by Cs+ cations. The layers consist of edge-sharing ∞1[Bi2S66−] and ∞1[MS34−] chains built from BiS6 octahedral and MS4 tetrahedral units. Two crystallographically unique Cs atoms are coordinated to S atoms in octahedral and monocapped trigonal prismatic environments. The structure of Cs2Bi2MS5, is related to that of Na2ZrCu2S4 and those of the AMM′Q3 materials (A=alkali metal, M=rare-earth or Group 4 element, M′= Group 11 or 12 element, Q=chalcogen). First-principles theoretical calculations indicate that Cs2Bi2ZnS5 and Cs2Bi2CdS5 are semiconductors with indirect band gaps of 1.85 and 1.75 eV, respectively. The experimental band gap for Cs2Bi2CdS5 is ≈1.7 eV, as derived from its optical absorption spectrum. 相似文献
56.
57.
P.V. Pogodin A.A. Lagunin D.A. Filimonov M.C. Nicklaus V.V. Poroikov 《SAR and QSAR in environmental research》2019,30(10):759-773
ABSTRACTExisting data on structures and biological activities are limited and distributed unevenly across distinct molecular targets and chemical compounds. The question arises if these data represent an unbiased sample of the general population of chemical-biological interactions. To answer this question, we analyzed ChEMBL data for 87,583 molecules tested against 919 protein targets using supervised and unsupervised approaches. Hierarchical clustering of the Murcko frameworks generated using Chemistry Development Toolkit showed that the available data form a big diffuse cloud without apparent structure. In contrast hereto, PASS-based classifiers allowed prediction whether the compound had been tested against the particular molecular target, despite whether it was active or not. Thus, one may conclude that the selection of chemical compounds for testing against specific targets is biased, probably due to the influence of prior knowledge. We assessed the possibility to improve (Q)SAR predictions using this fact: PASS prediction of the interaction with the particular target for compounds predicted as tested against the target has significantly higher accuracy than for those predicted as untested (average ROC AUC are about 0.87 and 0.75, respectively). Thus, considering the existing bias in the data of the training set may increase the performance of virtual screening. 相似文献
58.
Hybrid linear analysis (HLA), as a recent factor-based multivariate calibration technique, was applied for the spectrophotometric determination of ternary mixtures of pseudoephedrine hydrochloride (PSU), dextromethorphan hydrobromide (DXT), and sodium benzoate (BNZ). The utilized HLA was assisted by a wavelength selection procedure which was based on the calculation of the net analyte signal (NAS) regression plot in any considered wavelengths window for each test sample, in addition to a moving window strategy for searching the region with maximum linearity of NAS regression plot (minimum error indicator (EI)). HLA was applied because it was simpler to adapt to the NAS regression plot methodology, and also used less factors than partial least squares (PLS). An orthogonal array design was applied for formation of calibration and prediction sets in the concentration ranges 0-7500 μmol L−1 for PSU, 0-300 μmol L−1 for DXT, and 0-1400 μmol L−1 for BNZ. The method had the ability to select wavelength regions that minimize the effect of non-linearity of the spectral data, in addition to that of non-modeled interferences. The application of the selected wavelength regions improved the obtained relative standard error of predictions for PSU, DXT, and BNZ, respectively, from 5.24, 8.67, and 5.48% to 2.19, 5.21, and 3.62% (using lower number of factors). To check the ability of the proposed method in selection of linear regions of spectra, a test for detecting non-linear regions of spectral data in multivariate spectroscopic assays was also described. Additives in the commercial syrup samples did not interfere with their determinations. The method was successfully applied for the determination of pseudoephedrine HCl, dextromethorphan HBr, and sodium benzoate in cough suppressant syrup samples. 相似文献
59.
The influence of Stokes shift in optosensing was discussed. Then, the current status of large Stokes shift-based optosensing was reviewed here. 相似文献
60.
In on-column or in splitless injection with recondensation of the solvent, the length of the flooded zone in the column inlet depends primarily on the wettability of the internal wall of the inlet. For columns with a coated inlet this explains why peak distortion due to band broadening in space by a certain sample volume is pronounced in one case and hardly observable in another. Glass or fused silica capillaries silylated with diphenyltetramethyldisilazane were found to give optimal retention gaps. They combine thorough and thermostable deactivation with good wettability and low retention power. On the other hand it is very easy to deactivate fused silica capillaries with Carbowax. The resulting retention gaps are suitable for a wide range of applications and are particularly attractive for the analysis of dirty samples which require frequent replacement of the inlet. 相似文献