The electrochemical behavior of commercial clarithromycin and spectroscopic detection of its structural changes

The aim of the present study was to examine the behavior of commercial clarithromycin, Clathrocyn®, comparing to the results previously obtained using pure clarithromycin under the same experimental conditions. The study was performed by cyclic linear sweep voltammetry and the bulk of electrolyte was analyzed by FTIR spectroscopy and HPLC. At gold electrode, in the range of ?1.2 V to 1.0 V vs. SCE in 0.05 M NaHCO₃, the electrochemical determination of pure clarithromycin was previously defined by four anodic and one cathodic reproductive peaks, and commercial clarithromycin is defined by reproductive one anodic peak which appears from 0.60 to 0.80 V vs. SCE. Previously, FTIR analysis of the bulk electrolyte showed the apparent changes in pure clarithromycin molecule structure: in the ester bond of the lactone and in ethers and acetal bonds. FTIR analysis of the bulk electrolyte also showed changes in the molecule structure in commercial-tablets form of clarithromycin: indicating disappearance of lactone structure and changes of carbonyl group at position 9.     

Absence of neutron emission during interaction of deuterium with metal at low energies

Technique and instrumentation to detect reliably, multiplicity of neutrons emitted in sharp bursts (≤100 μs) has been developed where a burst of as low as 15 neutrons and continuous emission of ⋍10⁻¹ neutron/s may be detected. Using this technique, attempts were made to detect neutron emission from various experiments in which anomalous nuclear effects (or what is commonly referred to as cold fusion) may be expected to occur. No neutrons, above our detection threshold, were detected in the recent series of experiments.     

Studies on external peak broadening in open-tubular liquid chromatography systems using the exponentially modified Gaussian model

Summary To optimize performance in Open-Tubular Liquid Chromatography (OTLC) it is necessary to minimize external peak broadening. To see how to reduce the external broadening an insight into its origins is required. This can be obtained by careful evaluation of experimental results with peak deconvolution methods based on the exponentially modified Gaussian model and comparison with theoretical predictions. It is assumed that the column response is Gaussian and that the responses due to the external effects are exponential.For peak deconvolution the algorithm described by Yau was used. Simulations were carried out to check the performance of the algorithm in calculating the standard deviation and the time constant. The effects of the presence of more than one time constant and of the number of data points and their position were investigated. The limits within which reliable results can be obtained are reported.Experimental results were obtained with laser-induced fluorescence and mass spectrometric detection. It is shown that the Yau algorithm can be used to obtain physically realistic estimates of the contribution to peak distortion in the various system components. By suitable design external effects can be reduced to the order of 1 nl and in some cases even lower limits can be reached.Part of this paper was presented at the 3rd Workshop on LC/MS and MS/MS, October, 24–26, 1984 in Montreux, Switzerland.     

A counterexample to the existence of a local plurisubharmonic peak function at infinity

We give an example of an unbounded pseudoconvex Reinhardt domain in , which is Kobayashi complete but admits no local plurisubharmonic peak function at infinity.

     

Quasi-localized vibrations and phonon damping in glasses

There is ample evidence both from computer simulation and experiments that the structural disorder characterizing glasses and amorphous materials leads to quasi-localized vibrations (QLVs). The effect of these modes on low temperature properties such as heat capacity and conduction or tunnelling can be calculated in the framework of the soft potential model. Recently it has been shown that this concept can be extended to describe the boson peak (BP). By interaction, the density of states of the QLVs is changed to a characteristic shape corresponding to the boson peak in inelastic scattering. The QLVs interact with the sound waves and dampen them. We show that resonant scattering between QLVs and sound waves can describe the strong damping observed experimentally.     

Non-Debye excess heat capacity and boson peak of binary lithium borate glasses

The non-Debye excess heat capacities of binary lithium borate glasses with different Li₂O compositions of x = 8, 14 and 22 (mol%) are investigated to understand origin of the boson peak. The low-temperature heat capacities are measured between 2 and 50 K by a relaxation calorimeter. The experimental non-Debye heat capacities with x = 14 is successfully reproduced using the excess vibrational density of states measured by inelastic neutron scattering. This finding indicates that the non-Debye heat capacities of lithium borate glasses originate from the excess vibrational density of states measureable by inelastic neutron scattering. Moreover, it is demonstrated that all of the excess heat capacity spectra lie on a single master curve by the scaling using boson peak temperature and intensity.     

含铝炸药水下爆炸性能的实验研究

对RS211、HL-1、HL-2这3种含铝炸药和TNT炸药进行了水下爆炸实验,测量了4种炸药水下爆炸冲击波压力剖面和气泡脉动周期,获得了4种炸药水下爆炸冲击波的峰值超压、冲量、能量和气泡能。实验结果表明,在所研究的范围内,与TNT炸药相比,含铝炸药的冲击波能量有明显增加,约为TNT炸药的1.20～1.35倍,气泡能有显著增加,约为TNT炸药的1.50～2.30倍,表明在炸药中加入铝粉对于提高炸药水中爆炸威力是有益的。     

用两端对称缺陷复合光子晶体实现多通道滤波和光开关

用传输矩阵法计算了两端对称缺陷复合光子晶体结构的光传输特性。计算结果表明:两端对称缺陷复合光子晶体[D(AB)mD]2结构中的禁带出现两个完全共振透射峰。通过控制入射光强来微调光子晶体材料的介电常数,使得完全共振透射峰移动,且介电常数变化越大,共振透射峰偏移越大,从而形成高效率的双通道光开关。当光子晶体为[D(AB)mD]N结构时,每个完全共振透射峰都分裂为N-1条,这样可通过调节N同时实现所需要通道数目的高效多通道光开关和多通道滤波器。     

A method for extracting human gait series from accelerometer signals based on the ensemble empirical mode decomposition

In this paper,the ensemble empirical mode decomposition(EEMD) is applied to analyse accelerometer signals collected during normal human walking.First,the self-adaptive feature of EEMD is utilised to decompose the accelerometer signals,thus sifting out several intrinsic mode functions(IMFs) at disparate scales.Then,gait series can be extracted through peak detection from the eigen IMF that best represents gait rhythmicity.Compared with the method based on the empirical mode decomposition(EMD),the EEMD-based method has the following advantages:it remarkably improves the detection rate of peak values hidden in the original accelerometer signal,even when the signal is severely contaminated by the intermittent noises;this method effectively prevents the phenomenon of mode mixing found in the process of EMD.And a reasonable selection of parameters for the stop-filtering criteria can improve the calculation speed of the EEMD-based method.Meanwhile,the endpoint effect can be suppressed by using the auto regressive and moving average model to extend a short-time series in dual directions.The results suggest that EEMD is a powerful tool for extraction of gait rhythmicity and it also provides valuable clues for extracting eigen rhythm of other physiological signals.     

Pressure effect study on the I－V property of the GaAs-based resonant tunnelling structure by photoluminescence measurement

This paper discusses the I-V property of the GaAs-based resonant tunnelling structure （RTS） under external uniaxial pressure by photoluminescence studies. Compressive pressure parallel to the [110] direction, whose value is determined by Hooke＇s law, is imposed on the sample by a helix micrometer. With the increase of the applied external uniaxial compressive pressure, the blue shift and splitting of the luminescence peaks were observed, which have some influence on the I-V curve of RTS from the point of view of the energy gap, and the splitting became more apparent with applied pressure. Full width at half maximum broadening could also be observed.