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991.
Mukaiyama–Michael Reactions with trans‐2,5‐Diarylpyrrolidine Catalysts: Enantioselectivity Arises from Attractive Noncovalent Interactions,Not from Steric Hindrance
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Dr. Eeva K. Kemppainen Dr. Gokarneswar Sahoo Antti Piisola Andrea Hamza Bianka Kótai Dr. Imre Pápai Prof. Petri M. Pihko 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(20):5983-5993
The scope of the enantioselective Mukaiyama–Michael reactions catalyzed by trans‐2,5‐diphenylpyrrolidine has been expanded to include both α‐ and β‐substituted enals. However, the rationalization of the observed enantioselectivity is far from obvious since the catalyst is not very sterically hindered. DFT calculations were carried out to rationalize the observed stereoselectivities. Transition states of the C?C bond formation between iminium intermediates and silyloxyfurans were located and their relative energies were used to estimate the stereoselectivity data. We find excellent agreement between the predicted and observed stereoselectivities. The analysis of intermolecular forces reveals that the enantioselectivity is mostly due to stabilizing noncovalent interactions between the reacting partners, not due to steric hindrance. The role of attractive noncovalent interactions in enantioselective catalysis may be underappreciated. 相似文献
992.
New Concepts for Designing d10‐M(L)n Catalysts: d Regime,s Regime and Intrinsic Bite‐Angle Flexibility
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Lando P. Wolters Dr. Willem‐Jan van Zeist Prof. Dr. F. Matthias Bickelhaupt 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(36):11370-11381
Our aim is to understand the electronic and steric factors that determine the activity and selectivity of transition‐metal catalysts for cross‐coupling reactions. To this end, we have used the activation strain model to quantum‐chemically analyze the activity of catalyst complexes d10‐M(L)n toward methane C?H oxidative addition. We studied the effect of varying the metal center M along the nine d10 metal centers of Groups 9, 10, and 11 (M=Co?, Rh?, Ir?, Ni, Pd, Pt, Cu+, Ag+, Au+), and, for completeness, included variation from uncoordinated to mono‐ to bisligated systems (n=0, 1, 2), for the ligands L=NH3, PH3, and CO. Three concepts emerge from our activation strain analyses: 1) bite‐angle flexibility, 2) d‐regime catalysts, and 3) s‐regime catalysts. These concepts reveal new ways of tuning a catalyst’s activity. Interestingly, the flexibility of a catalyst complex, that is, its ability to adopt a bent L‐M‐L geometry, is shown to be decisive for its activity, not the bite angle as such. Furthermore, the effect of ligands on the catalyst’s activity is totally different, sometimes even opposite, depending on the electronic regime (d or s) of the d10‐M(L)n complex. Our findings therefore constitute new tools for a more rational design of catalysts. 相似文献
993.
Fe or FeNO Catalysis? A Quantum Chemical Investigation of the [Fe(CO)3(NO)]−‐Catalyzed Cloke–Wilson Rearrangement
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Johannes E. M. N. Klein Dr. Gerald Knizia Dr. Burkhard Miehlich Prof. Dr. Johannes Kästner Prof. Dr. Bernd Plietker 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(24):7254-7257
A quantum chemical investigation of the Bu4N[Fe(CO)3(NO)]‐catalyzed Cloke–Wilson rearrangement of vinyl cyclopropanes is reported. It was found that allylic C?C bond activation can proceed through a SN2′ or SN2‐type mechanism. The application of the recently reported intrinsic bond orbital (IBO) method for all structures indicated that one Fe?N π bond is directly involved. Further analysis showed that during the reaction oxidation occurs at the NO ligand exclusively. 相似文献
994.
On the Reaction Mechanism of the Complete Intermolecular O2 Transfer between Mononuclear Nickel and Manganese Complexes with Macrocyclic Ligands
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Dr. Jhon Zapata‐Rivera Prof. Rosa Caballol Dr. Carmen J. Calzado Dr. Dimitrios G. Liakos Prof. Frank Neese 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(41):13296-13304
The recently described intermolecular O2 transfer between the side‐on Ni‐O2 complex [(12‐TMC)Ni‐O2]+ and the manganese complex [(14‐TMC)Mn]2+, where 12‐TMC and 14‐TMC are 12‐ and 14‐membered macrocyclic ligands, 12‐TMC=1,4,7,10‐tetramethyl‐1,4,7,10‐tetraazacyclododecane and 14‐TMC=1,4,8,11‐tetramethyl‐1,4,8,11‐tetraazacyclotetradecane, is studied by means of DFT methods. B3LYP calculations including long‐range corrections and solvent effects are performed to elucidate the mechanism. The potential energy surfaces (PESs) compatible with different electronic states of the reactants have been analyzed. The calculations confirm a two‐step reaction, with a first rate‐determining bimolecular step and predict the exothermic character of the global process. The relative stability of the products and the reverse barrier are in line with the fact that no reverse reaction is experimentally observed. An intermediate with a μ‐η1:η1‐O2 coordination and two transition states are identified on the triplet PES, slightly below the corresponding stationary points of the quintet PES, suggesting an intersystem crossing before the first transition state. The calculated activation parameters and the relative energies of the two transition sates and the products are in very good agreement with the experimental data. The calculations suggest that a superoxide anion is transferred during the reaction. 相似文献
995.
Palladium–N‐Heterocyclic Carbene (NHC)‐Catalyzed Asymmetric Synthesis of Indolines through Regiodivergent C(sp3)H Activation: Scope and DFT Study
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Dmitry Katayev Dr. Evgeny Larionov Dr. Masafumi Nakanishi Dr. Céline Besnard Prof. Dr. E. Peter Kündig 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(46):15021-15030
Two bulky, chiral, monodentate N‐heterocyclic carbene ligands were applied to palladium‐catalyzed asymmetric C?H arylation to incorporate C(sp3)?H bond activation. Racemic mixtures of the carbamate starting materials underwent regiodivergent reactions to afford different trans‐2,3‐substituted indolines. Although this CAr?Calkyl coupling requires high temperatures (140–160 °C), chiral induction is high. This regiodivergent reaction, when carried out with enantiopure starting materials, can lead to single structurally different enantiopure products, depending on the catalyst chirality. The C?H activation at a tertiary center was realized only in the case of a cyclopropyl group. No C?H activation takes place alpha to a tertiary center. A detailed DFT study is included and analyses of methyl versus methylene versus methine C?H activation is used to rationalize experimentally observed regio‐ and enantioselectivities. 相似文献
996.
Aryl‐Copper(III)‐Acetylides as Key Intermediates in CCsp Model Couplings under Mild Conditions
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Mireia Rovira Marc Font Ferran Acuña‐Parés Dr. Teodor Parella Dr. Josep M. Luis Dr. Julio Lloret‐Fillol Dr. Xavi Ribas 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(32):10005-10010
The mechanism of copper‐mediated Sonogashira couplings (so‐called Stephens–Castro and Miura couplings) is not well understood and lacks clear comprehension. In this work, the reactivity of a well‐defined aryl‐CuIII species ( 1 ) with p‐R‐phenylacetylenes (R=NO2, CF3, H) is reported and it is found that facile reductive elimination from a putative aryl‐CuIII‐acetylide species occurs at room temperature to afford the Caryl?Csp coupling species ( IR ), which in turn undergo an intramolecular reorganisation to afford final heterocyclic products containing 2H‐isoindole ( P , P , PHa ) or 1,2‐dihydroisoquinoline ( PHb ) substructures. Density Functional Theory (DFT) studies support the postulated reductive elimination pathway that leads to the formation of C?Csp bonds and provide the clue to understand the divergent intramolecular reorganisation when p‐H‐phenylacetylene is used. Mechanistic insights and the very mild experimental conditions to effect Caryl?Csp coupling in these model systems provide important insights for developing milder copper‐catalysed Caryl?Csp coupling reactions with standard substrates in the future. 相似文献
997.
Determination of the Absolute Configuration of Perylene Quinone‐Derived Mycotoxins by Measurement and Calculation of Electronic Circular Dichroism Spectra and Specific Rotations
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Prof. Dr. Joachim Podlech Dr. Stefanie C. Fleck Prof. Dr. Manfred Metzler Dr. Jochen Bürck Prof. Dr. Anne S. Ulrich 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(36):11463-11470
Altertoxins I–III, alterlosins I and II, alteichin (alterperylenol), stemphyltoxins I–IV, stemphyperylenol, stemphytriol, 7‐epi‐8‐hydroxyaltertoxin I, and 6‐epi‐stemphytriol are mycotoxins derived from perylene quinone, for which the absolute configuration was not known. Electronic circular dichroism (ECD) spectra were calculated for these compounds and compared with measured spectra of altertoxins I–III, alteichin, and stemphyltoxin III and with reported Cotton effects. Specific rotations were calculated and compared with reported specific rotations. The absolute configuration of all the toxins, except for stemphyltoxin IV, could thus be determined. The validity of the assignment was high whenever reported ECD data were available for comparison, and the validity was lower when the assignment was based only on the comparison of calculated and reported specific rotations. ECD spectra are intrinsically different for toxins with a biphenyl substructure and for toxins derived from dihydroanthracene. 相似文献
998.
Transalkylation of Higher Trifluoromethylated Fullerenes with C70: A Pathway to New Addition Patterns of C70(CF3)8
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Nikita M. Belov Marina G. Apenova Alexey V. Rybalchenko Eugenia V. Borkovskaya Dr. Natalia S. Lukonina Dr. Alexey A. Goryunkov Dr. Ilya N. Ioffe Prof. Dr. Sergey I. Troyanov Prof. Dr. Lev N. Sidorov 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(4):1126-1133
We report three new isomers of C70(CF3)8, structurally related to p7mp‐C70(CF3)10, that are inaccessible by direct trifluoromethylation, but can be easily identified among the products of the transalkylation of higher trifluoromethylfullerenes with C70. The reported compounds are characterized by UV/Vis, 1 D and 2 D COSY 19F NMR spectroscopy, and DFT calculations. A rather unusual addition pattern is observed in p6,i‐C70(CF3)8 in which one addend is attached remotely from the others; polarization of the adjacent unsaturated bonds by the addend makes the molecule readily oxidizable. 相似文献
999.
Brandon Z. Child Dr. Santanab Giri Dr. Scott Gronert Dr. Puru Jena 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(16):4736-4745
No organic molecules with electron affinities near or above those of halogens are known. We show for the first time that aromaticity rules can be used to design molecules with electron affinities far exceeding those of halogen atoms either by tailoring the ligands of cyclopentadienyl or by multiple benzoannulations of cyclopentadienyl in conjunction with the substitution of CH groups with isoelectronic N atoms. Results based on density functional theory revealed that the electron affinities of some of these organic molecules can reach as high as 5.59 eV, thus opening the door to new class of superhalogens that contain neither a metal nor a halogen atom. 相似文献
1000.