聚乙烯醇固定化的微球菌AD3对除草剂阿特拉津的生物降解

从农药厂的工业废水和污泥的混合物中分离到高效降解除草剂阿特拉津的藤黄微球菌(Micrococcusluteus)AD3菌株。以聚乙烯醇(PVA)为包埋材料进行AD3菌株的固定化,对影响固定化细胞降解阿特拉津的因素(如阿特拉津浓度、温度、pH)和操作稳定性进行了研究。结果表明,在最适条件下(30℃、pH7.2、阿特拉津浓度500mg/L)固定化细胞的阿特拉津降解速度明显高于游离细胞。固定化细胞在低温、低pH和高阿特拉津浓度条件下的阿特拉津降解率,以及贮存和操作稳定性,也明显好于游离细胞。固定化细胞在15℃、pH7.2、阿特拉津浓度为500mg/L的条件下培养72h以后,阿特拉津降解率为90%,在相同条件下游离细胞的降解率仅为35%。固定化细胞在pH5.0、30℃、阿特拉津浓度为500mg/L的条件下培养72h以后,降解率为96%,在相同条件下游离细胞的降解率仅为40%。固定化细胞能够快速降解1000mg/L的阿特拉津,而游离细胞则不能。稳定性实验表明,固定化细胞重复使用30次以后其降解活力没有明显降低。     

采用移动极差统计合并技术来监控ICP-AES测量系统的不确定度

采用ICP AES(电感耦合等离子体 原子发射光谱法 )测定金属硅中铁杂质含量进行不确定度评估时 ,提出了平均移动极差 (MR)合并统计动态监控技术。研究认为 ,采用该技术来进行ICP AES测量系统的不确定度评估 ,其贡献量分别是由控制样品 (QC)和线性拟合两部分合成。这一结论的得出能最大限度合成各种变异因素的影响 ,避免了相关性的复杂计算 ,有利于ICP AES测量系统的不确定度评估     

对不良导体导热系数测量实验的改进

对稳态法测量导热系数的实验进行改进,用AD590温度传感器代替热电偶,实现了计算机对数据的采集和处理     

面向空气信道传播的音频信息隐写算法

基于傅立叶变换,提出了一种面向空气信道传播音频信息隐写算法.该算法选取原始音频信号傅立叶变换域中的低频系数,提取其相位角系数,并对其进行修改,将经BCH纠错编码的隐写信息嵌入,并且嵌入量较大,隐藏效果好.实验结果显示,该算法能够有效抵抗空气传播过程中的AD/DA变换攻击、空气噪声干扰攻击,以及录制后的常见信号处理攻击、约30%的重采样攻击等其他攻击,平均误码率可控制在3.5%以下,算法具有很好的鲁棒性.     

基于低功耗与强穿透的ECG传感器节点的设计与实现

针对矿井下信道环境的复杂性与特殊性, 设计并实现了基于低功耗与强穿透的ECG传感器节点. 通过对比论证传感器节点各模块选型, 提出了基于AD8232为心电信号采集芯片、STM 32F103C8T6为处理器以及SI4463为无线收发芯片的ECG传感器节点设计方案. 在阐述传感器节点的软件设计思路与低功耗策略的基础上, 对ECG传感器节点的功耗以及对于矿工ECG信号采集传输性能进行测试与分析.     

AD590传感器特性测量实验方法的改进研究

利用FD-WTC-D型恒温控制温度传感器实验仪来表征AD590集成电路温度传感器特性测量实验,重点阐述了实验原理电路图的改进,以及在数字温度计设计过程中定标和数据记录等实验方法的改进.改进之后的实验,便于操作、简单实用,增加了实验的严谨性、科学性和实验结果的准确性,该方法运用于实验教学中,效果明显.     

Oscillation death in coupled oscillators

We study dynamical behaviors in coupled nonlinear oscillators and find that under certain conditions, a whole coupled oscillator system can cease oscillation and transfer to a globally nonuniform stationary state [i.e., the so-called oscillation death (OD) state], and this phenomenon can be generally observed. This OD state depends on coupling strengths and is clearly different from previously studied amplitude death (AD) state, which refers to the phenomenon where the whole system is trapped into homogeneously steady state of a fixed point, which already exists but is unstable in the absence of coupling. For larger systems, very rich pattern structures of global death states are observed. These Turing-like patterns may share some essential features with the classical Turing pattern.      

星上定标系统探测器高精度信号处理电路的实现

针对星上定标系统对探测器信号处理的技术要求,采用高精度模数转换器件-VFC型A/D转换器AD650设计了一种从光电流转换为频率输出的高性能转换电路.以硅陷阱探测器为基础研制了标准探测器,介绍了标准探测器的组成及光学原理,说明了VFC型A/D转换电路的设计思想和实现方法.该电路利用积分原理,将输入电压(或电流)转换成频率输出,脉冲频率与输入电压(或电流)成比例,其精度高、线性度好,转换位数与速度可调,与CPU连线很少.对光谱辐亮度的探测实验表明,以此原理设计的电路其输出频率非线性误差为0.23%,非稳定性误差为0.020%/h,结果满足系统设计要求.     

γ-分泌酶抑制剂(LY411575)的合成工艺研究

对γ-分泌酶抑制剂(LY411575)的合成路线进行改进,新合成路线下该化合物的总收率为35%,比文献方法提高了16%;对关键中间体提前进行了手性拆分,从而使在制备最终产品的后3步反应中用到的原料减少了50%,降低了反应成本和最终产品的纯化难度.另外,对拆分过程中的主要因子进行了单因素实验,考察了各因素对产品的e.e.值和反应收率的影响.获得了最佳反应条件:D-(+)-二对甲基苯甲酰酒石酸为拆分试剂,甲醇作溶剂,加热到回流溶解,加入的溶剂量为每g底物12 m L,从回流降到室温所用时间控制在120 min,拆分的收率为40%,e.e.值为99%.     

New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment

New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers were synthesized as potential multifunctional agents for Alzheimer’s disease (AD) treatment. All compounds were potent inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with selectivity toward BChE. Lead compound 8c, 2,6-di-tert-butyl-4-{[2-(7,8,9,10- tetrahydro-6H-cyclohepta[b]quinolin-11-ylamino)-ethylimino]-methyl}-phenol exhibited an IC₅₀(AChE) = 1.90 ± 0.16 µM, IC₅₀(BChE) = 0.084 ± 0.008 µM, and 13.6 ± 1.2% propidium displacement at 20 μM. Compounds possessed low activity against carboxylesterase, indicating likely absence of clinically unwanted drug-drug interactions. Kinetics were consistent with mixed-type reversible inhibition of both cholinesterases. Docking indicated binding to catalytic and peripheral AChE sites; peripheral site binding along with propidium displacement suggest the potential of the hybrids to block AChE-induced β-amyloid aggregation, a disease-modifying effect. Compounds demonstrated high antioxidant activity in ABTS and FRAP assays as well as inhibition of luminol chemiluminescence and lipid peroxidation in mouse brain homogenates. Conjugates 8 with amine-containing spacers were better antioxidants than those with enamine spacers 7. Computational ADMET profiles for all compounds predicted good blood-brain barrier distribution (permeability), good intestinal absorption, and medium cardiac toxicity risk. Overall, based on their favorable pharmacological and ADMET profiles, conjugates 8 appear promising as candidates for AD therapeutics.