东天山成矿背景及规律

阐述了新疆东天山多金属成矿带的地质成矿背景，并对此进行了分析研究，通过对该区区域成矿背景分析、成矿带地层岩石组合、成矿带构造环境、矿带构造演化等的研究，发现了基本的成矿规律．     

QSAR based virtual screening derived identification of a novel hit as a SARS CoV-229E 3CLpro Inhibitor: GA-MLR QSAR modeling supported by molecular Docking,molecular dynamics simulation and MMGBSA calculation approaches

Congruous coronavirus drug targets and analogous lead molecules must be identified as quickly as possible to produce antiviral therapeutics against human coronavirus (HCoV SARS 3CLpro) infections. In the present communication, we bear recognized a HIT candidate for HCoV SARS 3CLpro inhibition. Four Parametric GA-MLR primarily based QSAR model (R2:0.84, R2adj:0.82, Q2loo: 0.78) was once promoted using a dataset over 37 structurally diverse molecules along QSAR based virtual screening (QSAR-VS), molecular docking (MD) then molecular dynamic simulation (MDS) analysis and MMGBSA calculations. The QSAR-based virtual screening was utilized to find novel lead molecules from an in-house database of 100 molecules. The QSAR-vS successfully offered a hit molecule with an improved _PEC₅₀ value from 5.88 to 6.08. The benzene ring, phenyl ring, amide oxygen and nitrogen, and other important pharmacophoric sites are revealed via MD and MDS studies. Ile164, Pro188, Leu190, Thr25, His41, Asn46, Thr47, Ser49, Asn189, Gln191, Thr47, and Asn141 are among the key amino acid residues in the S1 and S2 pocket. A stable complex of a lead molecule with the HCoV SARS 3CLpro was discovered using MDS. MM-GBSA calculations resulted from MD simulation results well supported with the binding energies calculated from the docking results. The results of this study can be exploited to develop a novel antiviral target, such as an HCoV SARS 3CLpro Inhibitor.     

东海区海岸带景观格局变化对生态系统服务价值的影响

对大尺度、长时序的海岸带景观格局和生态系统服务价值(ecosystem services value,ESV)的研究,有利于更好地促进区域生态系统保护工作的开展。以1990,1995,2000,2005,2010,2015年6期遥感影像解译结果为基础,对东海区海岸带景观格局变化特征和ESV时空演变进行了分析,并探讨了ESV与景观格局变化二者间的关系。结果表明,1990—2015年的25 a间,受人类活动的影响,东海区海岸带农田和海域面积大量减少,建设用地面积大幅增加;在所研究的5类地貌类型中,除中起伏山地外,其余地貌类型景观面积转移都较为剧烈。25 a间东海区海岸带斑块数量、斑块密度、边界密度、shannon多样性指数等不断增加,景观破碎化、复杂化、多样化增强。农田景观的最大斑块指数、形态指数、边界密度等变化均较大。东海区海岸带ESV呈先增加后减小的趋势,其中森林景观对ESV总量贡献最大;水文调节、生物多样性维持、气候调节、土壤保持、废物处理和气体调节是东海区海岸带主要的生态系统服务功能;在空间上表现出以单位面积中、低ESV为主导的空间分布,高、极高和极低ESV分布较少。研究区ESV总量与农田和海域以及水域和建设用地面积显著相关;与斑块密度、边界密度和形态指数呈显著负相关。同时,食物生产、气体调节、气候调节、土壤保持和生物多样性维持的服务价值与景观指数间均显著相关。     

Limit theorems for functionals of two independent Gaussian processes

Under certain mild conditions, some limit theorems for functionals of two independent Gaussian processes are obtained. The results apply to general Gaussian processes including fractional Brownian motion, sub-fractional Brownian motion and bi-fractional Brownian motion. A new and interesting phenomenon is that, in comparison with the results for fractional Brownian motion, extra randomness appears in the limiting distributions for Gaussian processes with nonstationary increments, say sub-fractional Brownian motion and bi-fractional Brownian. The results are obtained based on the method of moments, in which Fourier analysis, the chaining argument introduced in [11] and a pairing technique are employed.     

Palladium-catalyzed arylation/cyclization/desulfonation cascades toward 4-aryl quinolin-2(1H)-ones with diaryliodonium salts

Palladium-catalyzed cascades of arylation/cyclization/desulfonation of ortho-aminocinnamate esters by using diaryliodonium salts afforded a wide range of 4-aryl quinolin-2(1H)-ones. As such, the desired 4-aryl quinolin-2(1H)-ones with potential biological activity has been synthesized in the yields of 34–96%.     

东天山地区成矿规律及铜、金矿床分布

东天山地区横跨哈萨克斯坦与塔里木两大板块,是新疆最重要的有色金属、黑色金属和贵金属矿产地之一.经历了前震旦纪基底形成→震旦——泥盆纪古亚洲洋形成、消亡→石炭纪→早二叠世后碰撞造山→晚二叠世至今的陆内造山等阶段.主要成矿期为晚古生代早期（泥盆纪——二叠纪）,成矿作用复杂、类型繁多.其中,北部形成岛弧斑岩型和火山岩型铜、钼、金矿,中部形成拉张火山岩型和矽卡岩型金、铜、镍、银矿,中南部形成前寒武纪结晶基底叠加改造的层控一热液型铅、锌、银矿,南部库鲁克塔格和北山地区形成拉张铜、镍、金矿通过研究认为,东天山地区尤以铜、镍钼矿产资源潜力很大,优选出28个矿找矿靶区本文主要介绍东天山地区的成矿规律及铜、金矿床的分布.     

A Conversation with William A. Fowler – Part II

Physicist William A.Fowler initiated an experimental program in nuclear astrophysics after World War II. He recalls here the Steady State versus Big Bang controversy and his celebrated collaboration with Fred Hoyle and Geoffrey and Margaret Burbidge on nucleosynthesis in stars. He also comments on the shift away from nuclear physics in universities to large accelerators and national laboratories.John Greenberg received his Ph.D. degree from the University of Wisconsin and was Caltech research fellow in history from 1980–1984. The Editors were saddened to learn that he died while this interview was in press. Requests for reprints may be directed to Judith R. Goodstein, Institute Archives 015A-74, Caltech, Pasadena, CA 91125 USA; e-mail: jrg@caltech.edu.     

Extremal solutions to a system of n nonlinear differential equations and regularly varying functions

The strongly increasing and strongly decreasing solutions to a system of n nonlinear first order equations are here studied, under the assumption that both the coefficients and the nonlinearities are regularly varying functions. We establish conditions under which such solutions exist and are (all) regularly varying functions, we derive their index of regular variation and establish asymptotic representations. Several applications of the main results are given, involving n‐th order nonlinear differential equations, equations with a generalized ?‐Laplacian, and nonlinear partial differential systems.     

Tidal changes in the Yellow/East China Sea caused by the rapid sea-level rise during the Holocene

Two-dimensional numerical simulations of M2 and K1 tides were performed in order to assess the effect of the rapid sea level change occurring during the last 20000 years in the Yellow/East China Sea (YECS). Results were interpreted by utilizing the difference of the dynamical nature inherited in diurnal and semi-diurnal tides. M2 tides at the coastal region south of Korea exceeded 2 m in amplitude when the sea-level was low, and decreased as the water depth become larger. In the Yellow Sea, on the other hand, tidal amplitudes were small at the low sea-level stages and increased along with the sea-level rise. The way of the increase was not monotonic but with fluctuations, which was due to the movement of the standing wave nodes. An additional experiment with closing the Taiwan Strait revealed that changing the sill depth of the strait not only affects the M2 tides around the southeastern Chinese coast, but also modifies the tides around the southwestern coast of Korea. This result recall us the significa