高温环境下T300/BMP350拉伸力学行为研究

对不同温度下的耐高温树脂基复合材料T300/BMP350的0°和90°单向层合板进行静载拉伸实验,得到材料在不同温度下的应力-应变响应,分析了温度对材料的力学性能影响。通过高温应变片采集到材料在高温环境下的热输出和破坏时的极限应变,分析了材料的热行为。通过分析材料的应力-应变曲线和失效模式,研究了材料的损伤和失效机理。研究结果表明:T300/BMP350树脂基复合材料具有很好的耐高温性能。高温下0°方向的拉伸强度和模量保持率达到80%以上,90°方向的拉伸强度和模量保持率可以达到50%以上。高温环境对材料的极限应变影响不大,材料破坏模式均为脆性破坏。基于实验结果,对材料的强度随温度的变化进行拟合,预测了该材料在350℃时0°和90°的拉伸强度。     

Investigation of the adsorption behavior of glycine peptides on 12% cross-linked agarose gel media

The highly cross-linked 12% agarose gel Superose 12 10/300 GL causes retardation of glycine peptides when mobile phases containing varying concentrations of acetonitrile in water are used. An investigation has been made into the retention mechanism behind this retardation using the glycine dipeptide (GG) and tripeptide (GGG) as models. The dependence of retention times of analytical-size peaks under different experimental conditions was interpreted such that the adsorption most probably was caused by the formation of hydrogen bonds but that electrostatic interactions cannot be ruled out. Thereafter, a nonlinear adsorption study was undertaken at different acetonitrile content in the eluent, using the elution by characteristic points (ECPs) method on strongly overloaded GG and GGG peaks. With a new evaluation tool, the adsorption energy distribution (AED) could be calculated prior to the model selection. These calculations revealed that when the acetonitrile content in the eluent was varied from 0% to 20% the interactions turned from (i) being homogenous (GG) or mildly heterogeneous (GGG), (ii) via a more or less stronger degree of heterogeneity around one site to (iii) finally a typical bimodal energy interaction comprising of two sites (GG at 20% and GGG at 10% and 20%). The Langmuir, Tóth and bi-Langmuir models described these interesting adsorption trends excellently. Thus, the retardation observed for these glycine peptides is interpreted as being of mixed-mode character composed of electrostatic bonds and hydrogen bonds.     

基于ARMA-GARCH-SN模型的沪深300股指期货日内波动率研究与预测

运用五个交易日的股指期货高频数据(每秒两笔),本文主要研究了沪深300股指期货日内波动率特征并对日内波动率预测。研究发现高频股指期货日内收益率有明显的波动率聚集和条件异方差现象,但无尖峰厚尾现象,收益率序列分布符合有偏正态分布。因此,我们对时间序列建立了最优的ARMA-GARCH-SN模型,并对模型拟合充分性做了验证,拟合结果发现ARMA(1,2)-GARCH(1,1)-SN模型基本能够刻画股指期货高频日内波动特征,条件方差所受的冲击具有很强的持续性、日内波动也具有长记忆性,最后我们还利用自助法对高频股指期货日内波动率两步预测、利用滚动回归预测方法对样本做了样本内预测。预测结果表明,波动率预测结果能够较好地反映股指期货日内波动特征。     

Beyond the BET Family: Targeting CBP/p300 with 4‐Acyl Pyrroles

Bromodomain and extra‐terminal domain (BET) inhibitors are widely used both as chemical tools to study the biological role of their targets in living organisms and as candidates for drug development against several cancer variants and human disorders. However, non‐BET bromodomains such as those in p300 and CBP are less studied. XDM‐CBP is a highly potent and selective inhibitor for the bromodomains of CBP and p300 derived from a pan‐selective BET BRD‐binding fragment. Along with X‐ray crystal‐structure analysis and thermodynamic profiling, XDM‐CBP was used in screenings of several cancer cell lines in vitro to study its inhibitory potential on cancer cell proliferation. XDM‐CBP is demonstrated to be a potent and selective CBP/p300 inhibitor that acts on specific cancer cell lines, in particular malignant melanoma, breast cancer, and leukemia.     

Use of 3-hydroxyflavone as a fluorescence probe for the controlled photopolymerization of the E-Shell 300 polymer

Photopolymerization process of the photo-reactive acrylate-based E-Shell 300 biocompatible polymers doped with 3-hydroxyflavone (3-HF) molecules have been studied. It was found that the spectra of these complexes manifest two intensive fluorescence bands, the short-wavelength band of the E-Shell 300 autofluoresence and the long-wavelength emission band of the probe tautomer.The intensity and the relative quantum yield of 3-HF long-wavelength green band grew by 1.8 times during polymerization. They were characterized by continuous and single-valued response function to the polymerization progress. The function may be used as an indicator suitable for photopolymerization monitoring.Moreover, time-resolved measurements of the emission lifetimes showed significant difference between 3-HF emission lifetime in low viscous solvent (0.9 ns)) and in polymerized sample (3.2 ns)) which also can be applied in control of photopolymerization. 3-HF is a relatively cheap, non-toxic and has good solubility in the polymer media we chose.     

高温热裂解电催化剂Ketjen Black EC300J碳黑负载钴卟啉的氧还原性能

选用具有高介孔表面积和高导电性能的碳黑Ketjen Black EC 300J(简称KB)作为载体,制备了碳黑负载钴卟啉(CoTMPP/KB),经过900℃热处理后得到电催化剂,用于燃料电池阴极氧还原反应.利用循环伏安法(CV)研究了碳载体不同预处理方法以及高温热处理对碳黑负载钴卟啉电催化剂的氧还原催化性能的影响.结果...     

Chemical Synthesis of Proteins Containing 300 Amino Acids

Chemical synthesis of proteins containing up to 300 amino acids may cover 30%-50% of all the proteins encountered in biomedical studies and may provide an alternate approach to the usually used recombinant expression technology, vastly expanding the chemical space of the latter. In the present review article, we tried to survey the recent progresses made for more rapid synthesis of increasingly long peptides and more efficient ligation of multiple peptide segments. The developments of seminal methods by many research groups have greatly contributed to the recent breakthroughs in the successful total synthesis of a number of functionally important proteins, such as oligoubiquitins, bacterial GroEL/ES chaperones, and mirror-image DNA polymerases. Through these studies, a potential bottleneck has also been recognized for the chemical synthesis of large proteins, namely, how to ensure that each peptide segment from a large protein avoids unfavorable aggregation when dissolved in aqueous solution. Many new methods, such as removable backbone modification(RBM) strategy have been developed to overcome this bottleneck, while more studies need to be carried out to develop more effective and less costly methods that ultimately, may lead to fully automatable chemical synthesis of customized proteins of 300 amino acids bearing any artificial designs.     

碱融–离子色谱法测定抗氧剂300中的氯离子

采用碱融法处理样品,用离子色谱法测定抗氧剂300中的氯离子含量。氯离子质量浓度在0.1~60 mg/L范围内与色谱峰面积呈良好的线性关系,r=0.9982。测定结果的相对标准偏差为0.36%~1.14%(n=6),检出限为0.804μg/g,加标回收率为98.84%~100.90%。该法简便、快速,适合于抗氧剂300中氯离子含量的检测。     

Application of mercury porosimetry to the study of xerogels used as stone consolidants

Alkoxysilanes, low-viscosity monomers that polymerize into the porous network of stone by a sol-gel process, are widely used in the restoration of stone buildings. We have used the mercury porosimetry technique to characterize changes in microstructure of three granites following their consolidation with two popular commercial products (Wacker OH and Tegovakon V). The suitability of this technique is questioned because a surprising increase of stone porosity is observed. In order to investigate the feasibility of porosimetry, we analyze the behavior of xerogels prepared from the two commercial products, under mercury pressure. Gels are basically compacted and not intruded by mercury. Thus, the increase of stone porosity after consolidation can actually be associated with gel shrinkage. Mercury porosimetry, therefore, has been found unsuitable for characterizing the microstructure of consolidated rocks. However, it can be employed usefully to evaluate shrinkage of gels under mercury pressure, which permits the behavior of a consolidant during the process of drying in stone to be predicted. It is a key factor because many problems of consolidants are related to their drying process within the stone. Gels under study exhibit a high rigidity and an elastic behavior, as consequence of their microporous structure. Finally, the reduction in the porous volume of gels after the porosimetry test demonstrates that the shrinkage mechanism is based on pore collapse.     

Mechanical behaviour of highly porous glasses

The mechanical behaviour of highly porous glassy materials (pore volume higher than 85%) is investigated using Hg porosimetry. Because of the small pore size of these materials, Hg liquid cannot enter their porous network and consequently induces an isostatic pressure. Due to the high compliance of the solid network of these materials, compression results in the sample shrinkage. The experiments described in this paper show that an isostatic pressure applied to highly porous glasses induces an irreversible volume shrinkage which can be associated with an unexpected plastic behaviour and structure strengthening. The magnitude of the plastic shrinkage and the increase of the associated mechanical properties depend on the starting bulk density. The irreversible compaction can be explained by siloxane bond formation between clusters constituting the porous glasses, retaining the strained structure. This densification process could offer a new way to synthesise glasses at room temperature.