双龙方组分诱导大鼠BMSCs分化的差异基因筛选及聚类分析

利用基因芯片筛选双龙方有效组分(总人参皂苷及总丹酚酸)诱导大鼠骨髓间充质干细胞(BMSCs)类心肌细胞分化过程中的差异表达基因, 并对其进行聚类分析, 在基因水平研究了双龙方组分对大鼠BMSCs分化的影响. 对大鼠BMSCs进行分组培养, 分别收集10, 20, 30及40 d的细胞样本, 提取tRNA, 经基因芯片检测, 筛选出BMSCs变化过程中的差异表达基因并进行生物信息学分析, 同时通过差异表达基因对样本进行Hierarchical聚类分析. 在BMSCs的分化过程中, 筛选出179条差异表达基因, 经分析发现它们与能量代谢和信号传导等多类基因密切相关. 对样本进行聚类分析发现其聚为两大类: 10和20 d的样本聚为一类, 30和40 d的样本聚为一类. 说明BMSCs在20~30 d之间可能发生了显著的改变.     

DNA和RNA双链稳定性差异的理论研究

利用适用于分子间弱相互作用, 尤其是生物分子间的氢键相互作用的改进的半经验方法RM1_BH和达到线性标度的新的半经验算法以及SimuCal_SE方法, 与自主开发的量子化学程序包SimuPac 1.0, 对4组一系列DNA和RNA碱基的氢键结合能进行了计算. 这些计算包括单一碱基类型和混合碱基类型两大类情形, 最大的原子数达到1064个. 计算结果表明, 在碱基层数较少时, DNA和RNA氢键结合能差别不大; 在碱基层数较多时, RNA的氢键结合能明显高于DNA的氢键结合能; 嘌呤和嘧啶的排列方式对结合能略有影响, 但不影响上述趋势. 可见, 氢键对于RNA的稳定性差异起到重要的作用, 计算结果支持了实验的结论.     

The Role of Potential Structure in Excitation Functions of Synthesizing Superheavy Nuclei

The excitation functions of two very similar reaction channels, 58Fe＋ 208pb→ 265Hs ＋ 1n and 58Fe＋ 209Bi → 266Mt ＋1n are studied in the framework of the dinuclear system conception. The fusion probabilities are found to be strongly subject to the structure of the driving potential. Usually the fusion probability is hindered by a barrier from the injection channel towards the compound nuclear configuration. The barrier towards the mass symmetrical direction, however, also plays an important role for the fusion probability, because the barrier hinders the quasi-fission, and therefore helps fusion.     

Error Thresholds in Single-Peak Gaussian Distributed Fitness Landscapes

Based on the Eigen and Crow-Kimura models with a single-peak fitness landscape, we propose the fitness values of all sequence types to be Gausslan distributed random variables to incorporate the effects of the fluctuations of the fitness landscapes （noise of environments） and investigate the concentration distribution and error threshold of quasispecies by performing an ensemble average within this theoretical framework. We find that a small fluctuation of the fitness landscape causes only a slight change in the concentration distribution and error threshold, which implies that the error threshold is stable against small perturbations. However, for a sizable fluctuation, quite different from the previous deterministic models, our statistical results show that the transition from quasi-species to error catastrophe is not so sharp, indicating that the error threshold is located within a certain range and has a shift toward a larger value. Our results are qualitatively in agreement with the experimental data and provide a new implication for antiviral strategies.     

Remote Operation on Quantum State Among Multiparty

In this paper, a scheme is proposed for performing remote operation on quantum state among multiparty. We use three-particle GHZ state as quantum channels to prepare a state operator, which describes quantum correlation between states and operations. Based on the special characteristic of the state operator, observers can perform unitary operation on a system that is away from observers. Our studies show this process is deterministic. We further consider remote operation among N spatially distributed observers, and the results show the successful realization of remote operation needs collective participation of N parties, that is, there exists strong correlation among multiparty. In addition, we investigate the case in which observers share a three-particle W state as quantum channels to perform remote operation and studies find this process is probabilistic.     

Energy Spectrum of a Degenerate Fermi Gas at the BEC-BCS Crossover

A theoretical study of the BCS-BEC crossover is presented. Starting from a two-channel Boson-Fermion resonance model, the BCS-Bogoiubov mean-field method and the Green＇s function method are adopted. The result shows that we can end up with a BCS-type theory but with a composite order parameter. Calculation shows that the Bose condensate of BCS Cooper pairs is proportional to the molecular BEC of Bose molecules. The resonance superfluid phase is indicated by the energy spectrum with an obvious interpretation of the transition mechanism.     

Dark Solitons in FPU Lattice Chain

Based on multiple scales method, we study the nonlinear properties of a new Fermi-Pasta-Ulam lattice model analytically. It is found that the lattice chain exhibits a novel nonlinear elementary excitation, i.e. a dark soliton. Moreover, the modulation depth of dark soliton is increasing as the anharmonic parameter increases.     

Stimulated emission and multi-peaked absorption in a four level N-type atom

Absorption and refraction of the inner transition F₂\leftrightarrow F₃ of the closed four level N-type atom have been investigated under a weak field. The outer transitions F₁\leftrightarrow F₃ and F₂\leftrightarrow F₄ are resonantly interacted with drive field with frequency \omega_c and Rabi frequency \Omega_c, and saturation field with \Omega_s and \Omega_s, respectively. For the suitable Rabi frequencies \Omega_c and \Omega_s, we obtain the Mollow absorption spectrum of probe field. The reason is that the drive field excites the atom to the upper level F_c and simultaneously the saturation field takes the atom out of the lower level F₂, leading to the stimulated emission. Meanwhile, due to the dynamic energy splitting induced by the drive and saturation fields, the two- and four-peaked absorption spectra are observed. At the zero off-resonance detuning of probe field, we also find the transfer of dispersion from negative to positive with an increment of \Omega_s. Finally, the refractive index enhancement is predicted for a wide spectral region.     

Influence of Solvent-Solvent and Solute-Solvent Interaction Properties on Solvent-Mediated Potential

A recently proposed universal calculational recipe for solvent-mediated potential is applied to calculate excess potential of mean force between two large Lennard-Jones （LJ） or hard core attractive Yukawa particles immersed in small LJ solvent bath at supercritical state. Comparison between the present prediction with a hypernetted chain approximation adopted for solute-solute correlation at infinitely dilute limit and existing simulation data shows high accuracy for the region with large separation, and qualitative reliability for the solute particle contact region. The calculational simplicity of the present recipe allows for a detailed investigation on the effect of the solute-solvent and solvent-solvent interaction details on the excess potential of mean force. The resultant conclusion is that gathering of solvent particles near a solute particle leads to repulsive excess PMF, while depletion of solvent particles away from the solute particle leads to attractive excess PMF, and minor change of the solvent-solvent interaction range has large influence on the excess PMF.     

Net Charge Fluctuation and String Fragmentation

We present the simulation results of the net charge fluctuation in Au Au collisions at √Snn=130 GeV from a dynamic model, JPCIAE, and its revisions. The simulations are done for the quark-gluon matter, the directly produced pions, the pion matter, and the hadron matter. The simulated net charge fluctuation of the quark-gluon matter is close to the thermal model prediction for the quark-gluon gas. However, the discrepancy exists comparing the simulated net charge fluctuation for directly produced pions and the pion matter with the thermal model prediction for pion gas and the resonance pion gas, respectively. The net charge fluctuation of hadron matter from default JPCIAE simulations is nearly 3.5 times larger than quark-gluon matter. A discussion is given for the net charge fluctuation as an evidence of QGP phase transition.