抗癌药物的电化学研究(Ⅱ)道诺霉素在DNA修饰石墨粉末微电极上的电化学行为及分析应用

研究了道诺霉素 ( DNM)在石墨粉末微电极和 DNA修饰石墨粉末微电极上的电化学行为 ,并分析了产生差别的原因。在此基础上 ,提出了测定微量 DNM的方法 ,DNM浓度在 1 .0× 1 0 - 7～ 1 .0× 1 0 - 5mol/L之间其微分脉冲伏安 ( DPV)峰电流与浓度有良好的线性关系 ,检出限为 5 .0× 1 0 - 8mol/L。采用标准加入法测定了模拟样品中的 DNM,回收率在 94%～ 1 0 8%之间 ,结果令人满意     

SiO2大分子单体与苯乙烯共聚制备PS/SiO2纳米复合材料

利用过量的2,4-甲苯二异氰酸酯(TDI)对SiO₂纳米粒子表面进行修饰合成出表面含—NCO基团的功能化SiO₂(SiO₂-TDI), 功能化SiO₂与丙烯酸羟丙酯(HPA)反应将表面－NCO转化为可聚合乙烯基合成大分子单体(SiO₂-HPA). 用传统自由基共聚方法利用苯乙烯(St)与SiO₂大分子单体共聚制备PS/SiO₂纳米复合材料. 系统研究了单体投料比及聚合时间对共聚反应的影响. 此外, 利用红外光谱(FTIR), DSC和TGA 等实验手段对纳米复合材料进行了表征分析. 结果表明: 共聚产物为一交联结构, SiO₂纳米粒子在复合材料中起着物理交联点和化学交联点作用; 复合材料玻璃化转变温度(T_g)明显地高于其均聚物玻璃化转变温度, 随着纳米SiO₂含量的增加, 复合材料玻璃化温度升高.     

新型光学活性α-氨基磷酸及其酯合成进展

α-氨基膦酸酯是一类很重要的天然氨基酸类似物，具有新颖的化学结构和多 种生理活性。综述了近年来光学活性α-氨基膦酸及酯的合成进展。     

3—（p—甲苯基）磺酰氨基—2，6—哌啶二酮（C12H14O4N2S）的晶体结构和分子

采用X－射线单晶衍射和INDO量子化学计算法研究了标题化合物的晶体和分子结构，标题化合物的分子式C12H14O4N2S，Mr=282.31，三斜晶系，空间群P1，a=7.229(2),b=8.7922(9),c=11.242(1)A;A=70.339(8),β＝71。15（2），γ＝87．88（2）°，V=634.8(7)A^3,Z=2,Dc=1.476g/cm^3,R=0.037,Rw=0.037(W=1),分子的哌啶二酮环中C＝0和C－N键与多肽分子和相应键长相一致，根据INDO计算结果讨论了标题化合物的水解反应活性。     

血红素LB膜的电化学行为

采用循环伏安法研究了血红素与脑磷脂混合Y型LB（Langmuir-Blodgett）膜在玻碳电极上的电化学行为，结果表明血红素LB膜有良好的电化学活性，在0．1mol/L KCl溶液中有一对氧化还原峰（－0．42V／－0．30V）；将血红素LB膜转移到玻碳电极表面得到的血红素LB膜修饰电极（heme LB-GC）对溶液中溶解氧的电化学还原有良好的催化作用，其催化还原过程具有不可逆电荷传递特性。     

纳米CoHCF修饰电极的制备及其对血红蛋白的电化学测定研究

A cobalt hexacyanoferrate （CoHCF） nanoparticle （size ca. 60 nm） chemically modified electrode （CME） was fabricated and the electrochemical behavior of hemoglobin （Hb） at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode （GCE） and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife, Combined with liquid chromatography （LC）, the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis-electrochemical determination （FIA-ECD） system. The peak current was a linear function of concentrations in the range from 2.5×10^-8 to 5.0×10^-6mol/L for Hb, with detection limit of 1.4×10^-8 mol/L. The FIA-ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample-consumption.     

一维梯状配合物{[Cu2（4,4′-bpy）3（p-Ab）2（H2O）2]·（NO3）2·4H2O}n的晶体结构

合成了一维分子梯状配合物{[Cu2(4,4′-bpy)3(p-Ab)2(H2O)2].(NO3)2.4H2O}n(4,4′-bpy=4,4′-联吡啶,p-Ab-=对氨基苯甲酸根离子),该配合物晶体属单斜晶系,P2(1)/c空间群,晶胞参数:a=1.1107(5)nm,b=1.5504(3)nm,c=1.4509(3)nm,β=104.81(3)°,V=2.4155(12)nm3,Z=2.铜离子周围有3个氧原子和3个氮原子与之配位,其中2个氧原子由对氨基苯甲酸的螯合氧原子提供,另一个氧原子由配位水提供,3个氮原子分别由三个4,4′-联吡啶提供.这六个原子在铜离子周围形成一个畸变的八面体配位环境.配体对氨基苯甲酸只有一种配位形式——双齿螯合,第二配体4,4′-联吡啶的两个氮原子均参与配位,将配合物组装成一维分子梯结构.     

方酸染料在远红光区／近红外区对纳米晶二氧化钛电极的高效敏化作用

Four para-dialkylaminophenyl （PDAAP1-PDAAP4） bearing carboxyl groups were studied for application to the dye-sensitized solar cells （DSC）. It was found the short spacer CH2 between carboxyl and dialkylaminophenyl chromophore in PDAAP3 and PDAAP4 led to highly efficient monochromatic incident photon-to-current conversion efficiencies （IPCE）, however the long alkyl group C4H9 attached on aniline moieties in PDAAP2 and PDAAP4 favored improvement of open-circuit photovoltage. Thus, the solar cell sensitized by PDAAP4, having both short carboxyl groups CH2COOH and long alkyl groups C4H9, exhibited the IPCE maximum of 73% at 670 nm and overall energy conversion efficiency η of 3.06%, representing the highest IPCE and η values so far in dialkylaminophenyl-based organic dye-sensitized semiconductor solar cells. Taking advantage of the highly efficient sensitizing ability of PDAAP4 in far-red region, the data of IPCE above 630 nm of the solar cells were improved greatly by cosensitization with both N3 and PDAAP4. The influences of the TiO2 film thickness and the concentration of 4-tert-butylpyridine （TBP） in electrolyte were also investigated.     

3-氨基环己基甲酸和cis-3-氨基环己烯基-5-甲酸立体异构体的合成

通过手性胺拆分方法，从3-环己烯基甲酸出发分别合成得到了3-氨基环己基甲酸（ACHC）的四个立体异构体，以及cis-5-氨基-3-环己烯基甲酸（ACHEC）的二个立体异构体。     

Crystal Structure and Biological Activities of （R）-N′-[2-（4-Methoxy-6-chloro）-pyrimidinyl]- N-[3-methyl-2-（4-chlorophenyl）butyryl]-urea

1 INTRODUCTION The acyl ureas are a kind of high biological acti- vity compounds with low toxicity to mammals, birds, fish, amphibians, etc., and significant organic synthe- sis intermediates working extensively as insecticides, pesticides, fungicides and herbicides in agrochemi- cal industry[1～7]. While pyrimidinyl derivatives show excellent biological activities in the development of pesticide, and are used to develop high effective and high select herbicides. For example, pyrimidiny su…