Studies on β2-Glycoprotein Ⅰ Recognizing Molecules from a Phage Peptide Library

β2-Glycoprotein I(β2-GPI) has been identified as a cofactor in the recognition of phospholipid Ag cardiolipin (CL) by anticardiolipin Ab(aCL) purified from patients' serum with autoimmune disease. However, there is a considerable controversy as to the anti-β2-GPI -antibodies occurred in aCL. In order to select β2-GPI recognizing molecules, β2-GPI was used as a probe to screen affinity phage clones panned from a phage peptide library. After four cycles of selection, the phage recovery increased from 2.4×10-5% to 1.1×10-3%, indicating that a specific enrichment had been achieved. In order to characterize these phage clones, we investigated their specific binding to β2-GPI and their inhibition of β2-GPI binding to anti-β2-GPI antibodies. Almost 40 percent of clones reflected considerable binding abilities and inhibitory activities towards anti-β2-GPI antibodies. A group of related peptides were identified by DNA sequencing, in which there were seven related peptide sequences, with four of them representing more than once. These peptide sequences display similarities at several positions. Sequence motif (-F-S-L-) was evident in most of the peptides. It suggests that these peptides may specifically block the anti-β2-GPI antibodies binding to β2-GPI. Our result supports the idea that β2-GPI acts as a Ag for these anti-β2-GPI antibodies occurred in the aCL.     

TIME—RESOLVED X—RAY SPECTRA AND ATOMIC PROCESSES

In this article we will discuss time-resolved He-like X-ray spectra of titanium ions from a TFTR tokamak plasma[1] and of iron ions from solar flares[2] in particular attention to a presence of high energy electrons which affect the spectra and ionization balances.We consider a model that a hot component interacts with a bulk plasma.With this model,the time evolution of the spectra and ionization balaces derived therefrom can be described consistently.     

质子交换MgO:LiNbO3波导的双层结构

本文报导MgO:LiN_bO₃质子交换波导X射线双晶衍射和红外吸收的实验结果。这些结果表明质子交换波导由浅表面层和深表面层构成。浅表面层是一个连续应变层,有着大量随机排列的O—H—O形式的缔合OH^-基团。深表面层是一个均匀应变层,其内H⁺以自由OH^-基团形式出现。质子交换波导折射串不稳定性与双层结构中的结构驰豫密切相关。通过对质子交换过程的分析,提出两条避免双层结构的途径,其一为降低交换剂中的H⁺浓度,另一条是采用有限源工艺。     

含金双硫螯合配体簇合物的研究 II: [Mo2Fe2(μ3-S)4(S2CNEt2)5]·CH3CN的合成, 结构和性质

在无氧非水介质中, 以(NH4)2MoS4, FeCl3和NaS2CNEt2为原料合成了簇合物[Mo2Fe2S4(S2CNEt2)5]·CH3CN。X射线单晶结构测定表明, 它具有[Mo2Fe2S4]^5^+类立方烷核心骨架。每个金属原子有一螯合基团S2CNEt2配位。第五个S2CNEt2基团在两个Mo原子间跨桥配位。XPS和Mossbauer谱的测定及M-S(M=Fe或Mo)键长比较表明, 簇合物中Fe原子的氧化态是不同的, 而两个Mo原子则具有相同的氧化态, 该簇合物为顺磁性物质, μm=4.27μs。此外, 还测定了它的红外光谱, 紫外-可见光谱和催化乙炔还原活性。     

_Na_0.5_Bi_0.5_TiO_3结晶学表征及其固溶体的X射线研究

Na_0.5_Bi_0.5_TiO_3-BaTiO_3_ ,系统在一定组成范围内是性能优良而独特的超声换能器陶瓷新材料. 本文工作用X射线粉末衍射方法精确测定了单组分Na_0.5_Bi_0.5_TiO_3,的晶胞参数,提出与前所报道不同的新的晶胞类型; 在此基础上给出该系统不同组成点的晶格参数, 并对性能、晶格参数和组成之间关系和相关系作初步讨论. 关键词：