水中总磷测定校准曲线制作探讨

对过硫酸钾消解－钼蓝比色法测定水中总磷的标准曲线和标准工作曲线进行了实验比较,两者在空白试验、重现性试验和空白加标回收试验等方面均无显著性差异。     

全面质量管理与统计技术

本文指出了ISO90 0 0论证中存在的问题 ,并提出了相应的挽救措施 ,特别是在全面质量管理中更应该重视统计技术的应用     

Total Synthesis of Five Lipoteichoic acids of Clostridium difficile

The emergence of hypervirulent resistant strains have made Clostridium difficile a notorious nosocomial pathogen and has resulted in a renewed interest in preventive strategies, such as vaccines based on (synthetic) cell wall antigens. Recently, the structure of the lipoteichoic acid (LTA) of this species has been elucidated. Additionally, this LTA was found to induce the formation of protective antibodies against C. difficile in rabbits and mice. The LTA from C. difficile is isolated as a microheterogenous mixture, differing in size and composition, impeding any structure–activity relationship studies. To ensure reliable biological results, pure and well‐defined synthetic samples are required. In this work the total synthesis of LTAs from C. difficile with defined chain length is described and the initial biological results are presented.     

First Atroposelective Total Synthesis of Enantiomerically Pure Ancistrocladidine and Ancistrotectorine

The first regio‐ and stereoselective total synthesis of the axially chiral 7,3′‐coupled naphthylisoquinoline alkaloids ancistrocladidine ( 1 ) and ancistrotectorine ( 2 ) has been described. Both possess a 7,3′‐coupled axis, which before now, was difficult to attain synthetically. Moreover, target 2 has a sensitive relative cis‐array of the two methyl groups at C1 and C3 in the tetrahydroisoquinoline part. The key step in the chosen strategy was the construction of the biaryl axis in accordance with the “lactone method”: the two molecular halves, which were activated in an “inverse‐halogenated” form, were prefixed by an ester bridge, followed by intramolecular coupling, and atroposelective cleavage of the lactone auxiliary bridge delivered the desired biaryl scaffold.     

Blossoms and Optimal Bases

It is now classical to define blossoms by means of intersections of osculating flats. We consider here the most general context of spline spaces with sections in arbitrary extended Chebyshev spaces and with connections defined by arbitrary lower triangular matrices with positive diagonal elements. We show how the existence of blossoms in such spaces automatically leads to optimal bases in the sense of Carnicer and Peña.