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61.
Alexander Bauer Claudia Czado 《Journal of computational and graphical statistics》2016,25(4):1248-1271
Pair-copula Bayesian networks (PCBNs) are a novel class of multivariate statistical models, which combine the distributional flexibility of pair-copula constructions (PCCs) with the parsimony of conditional independence models associated with directed acyclic graphs (DAGs). We are first to provide generic algorithms for random sampling and likelihood inference in arbitrary PCBNs as well as for selecting orderings of the parents of the vertices in the underlying graphs. Model selection of the DAG is facilitated using a version of the well-known PC algorithm that is based on a novel test for conditional independence of random variables tailored to the PCC framework. A simulation study shows the PC algorithm’s high aptitude for structure estimation in non-Gaussian PCBNs. The proposed methods are finally applied to modeling financial return data. Supplementary materials for this article are available online. 相似文献
62.
以聚对苯二甲酸丁二醇酯(PBT)与双酚A型聚碳酸酯(PC)为基体、氧化铝(Al2O3)作为导热填料,通过熔融共混法制备了PBT/PC/Al_2O_3导热复合材料,采用亚磷酸三苯酯(TPPi)作为酯交换反应抑制剂调节材料中树脂基体的相态结构,并通过红外光谱分析(FTIR)、激光导热仪、扫描电子显微镜(SEM)、示差扫描量热仪(DSC)及力学性能测试仪等对材料中的酯交换反应、导热性能、相态结构、结晶参数及力学性能进行了表征.实验结果表明,TPPi的加入可有效抑制体系中酯交换反应的发生,使PBT/PC共混物的相态结构改变,进而对填料的分布状态产生影响.当PBT/PC配比为1/1时,向其中加入1 wt%的TPPi可使体系的相态结构趋向于形成双连续相态结构,并有效提升材料的导热系数;在该体系中加入60 wt%的Al_2O_3后,材料的导热系数达到0.89 W/(m·K),相对于未加入TPPi的相同体系提升了13%. 相似文献
63.
Screening and isolation of potential lactate dehydrogenase inhibitors from five Chinese medicinal herbs: Soybean,Radix pueraria,Flos pueraria,Rhizoma belamcandae,and Radix astragali
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Ying Tang Senlin Li Sainan Li Xiaojing Yang Yao Qin Yuchi Zhang Chunming Liu 《Journal of separation science》2016,39(11):2043-2049
Stroke is among the leading causes of death and severe disability worldwide. Flavonoids have been extensively used in the treatment of ischemic stroke by reducing lactate dehydrogenase levels and thereby enhancing blood perfusion to the ischemic region. Here, we used ultrafiltration high‐performance liquid chromatography coupled with diode array detection and mass spectrometry for the rapid screening and identification of flavonoids from five Chinese medicinal herbs: soybean, Radix pueraria, Flos pueraria, Rhizoma belamcandae, and Radix astragali. Using PC12 cells as a suitable in vitro model of toxicity, cell viability was quantitated using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. The results showed that the extracts of soybean and the six major components, namely, acetyldaidzin, malonylgenistin, daidiain, glycitin, genistin, and acetylcitin; the extract of R. pueraria and its main component daidzein; the extract of F. pueraria and its three major components, tectorigenin, tectoridin, and tectorigenin‐7‐O‐xylosylglucosid; and the extract of R. belamcandae and its main component, tectoridin, were strong lactate dehydrogenase inhibitors. Also, the components of R. astragali showed no bioactivity. These findings indicate that the ultrafltration high‐performance liquid chromatography coupled with diode array detection and mass spectrometry method could be utilized in rapid screening and separation of bioactive compounds from a complex matrix. 相似文献
64.
Ultrafiltration‐LC–MS combined with semi‐preparative HPLC for the simultaneous screening and isolation of lactate dehydrogenase inhibitors from Belamcanda chinensis
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Senlin Li Sainan Li Ying Tang Chunming Liu Lina Chen Yuchi Zhang 《Journal of separation science》2016,39(23):4533-4543
Stroke represents the fourth leading cause of death in the USA and the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are widely used in the treatment of ischemic stroke and natural products are considered a promising source of novel lactate dehydrogenase inhibitors. In this study, we used PC12 cells to determine the protective effect of extracts from the herb Belamcanda chinensis following toxic challenge. Using ultrafiltration high‐performance liquid chromatography coupled with photo‐diode array detection and electrospray ionization mass spectrometry, we screened and identified isoflavonoids from Belamcanda chinensis extracts. Semi‐preparative high‐performance liquid chromatography was then applied to separate and isolate the active constituents. Using these methods, we identified six major compounds in Belamcanda chinensis as lactate dehydrogenase inhibitors: tectoridin, iristectorin A, iridin, tectorigenin, irigenin, and irisflorentin, which were then isolated to >92% purity. This is the first report that Belamcanda chinensis extracts contain potent lactate dehydrogenase inhibitors. Our results demonstrate that the systematic isolation of bioactive components from Belamcanda chinensis guided by ultrafiltration high‐performance liquid chromatography coupled with photo‐diode array detection and electrospray ionization mass spectrometry represents a feasible and efficient technique that could be extended for the identification and isolation of other enzyme inhibitors. 相似文献
65.
本文介绍基于IBM—PC/XT的图象工作站仿真软件。把IBM—PC/XT变成图象工作站的仿真软件,为在IBM—PC/XT(及其兼容机)上,开发图象功能软件的用户提供了一个有效的方法。 相似文献
66.
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68.
用显微红外光谱法研究高分子共混物溶液自组织形成的相组成分布 总被引:4,自引:0,他引:4
本文制备了PS/PC(7/3)和PS/PMMA(5/5)的四氢呋喃(THF)溶液,通过缓慢蒸发溶剂制得PS/PC和PS/PMMA的共混物薄膜。利用不同的FTIR测试方法检测了制得薄膜中的组成分布。将PS/PC薄膜超薄切片,通过显微投射红外方法检测了其纵剖面的组成分布(测试步长为16μm)。结果表明:PS含量从膜底面到表面缓慢增大呈梯度分布,在膜表面附近急剧增大,即PS组分在成膜过程中向表面(与空气 相似文献
69.
回顾了有限元并行计算发展的历史,阐述了微机网络并行计算环境的意义,给出了基于微机网络并行环境的杆壳组合结构动力分析并行算法,该算法包括杆壳组合结构总刚度矩阵和总质量矩阵的并行计算以及求解广义特征值问题的并行子空间迭代法的并行计算,在多台微机上安装PVM.使用Linux操作系统.构成分布式微机网络并行计算环境,将上述算法用于某型号飞机机翼及某型号挂架动力特性的并行计算,在该并行环境下的教值试验表明所给算法是非常有效的。 相似文献
70.
Effects of trans reactions on the morphology, glass transition, and phase behavior in a classical blend system of a poly(hydroxyl ether bisphenol-A) (phenoxy) with bisphenol-A polycarbonate (PC) were investigated by differential scanning calorimetry (DSC) and optical microscopy. Although two Tgs were observed in the as-prepared PC/phenoxy blends, an apparently single, but broadened, Tg was found in the blends after heating at high temperatures, typically 200–250°C for short times. The optical microscopy results indicated that same scales of heterogeneity did exist in post-heated PC/phenoxy blends as well as unheated blends. Explanations were provided. After heating-induced interchange reactions ( OH and carbonate), randomly linked polymer chains might form at the numerous interfaces of the mutually occluded/included micro-domains. The majority of the chains in the micro-domains are forced to relax in coordinated motion modes after heating, thus showing a single Tg. A mechanism of trans reactions in interfacial regions was briefly discussed in supplement to earlier reports in the literature. © 1997 John Wiley & Sons, Inc. 相似文献