4-[(E)-2-(3,4,5-三甲氧基苯基)乙烯基]苯氧基羧酸酯的合成及抗肿瘤活性研究

二苯乙烯的多种衍生物表现出一系列的生理活性,如3,4,5.三羟基二苯乙烯(白藜芦醇)具有预防心脏病,抑制血小板凝聚,调控脂质和脂蛋白代谢,抗氧化及对癌症的治疗等作用[1-3].     

苯甲酸-Fenton体系荧光法测定中草药抗氧化活性

利用Feton体系产生羟自由基,能与苯甲酸反应生成具有强荧光的产物,加入抗氧化剂可有效清除羟自由基,导致体系荧光强度降低.据此建立了筛选抗氧化剂的荧光新体系.应用所建立的方法测定了葛根、吴茱萸和黄连三种常见中草药的抗氧化活性.结果表明,当中草药的浓度为0.4 mg(dry weight)/mL时,葛根、吴茱萸、黄连对羟...     

以三唑农药为配体的两个铜配合物的合成、晶体结构与抑菌活性(英文)

由三唑农药烯效唑和多效唑合成了2个铜配合物[CuL14Cl2](1)和[CuL24Cl2·4H2O](2)(L1=uniconazole,L2=paclobutrazol)。通过元素分析、红外光谱和X-ray单晶衍射对其结构进行了表征。结构分析表明,1属三斜晶系,P1空间群,晶胞参数为a=0.895 6(3)nm,b=1.326 7(4)nm,c=1.491 8(4)nm,α=94.828(3)°,β=97.774(3)°,γ=105.280(3)°,V=1.680 8(9)nm3。2属三斜晶系,P1空间群,晶胞参数为a=1.021 89(19)nm,b=1.329(3)nm,c=1.366 4(3)nm,α=81.564(2)°,β=79.508(2)°,γ=79.185(2)°,V=1.785 3(7)nm3。在2个配合物中,六配位的铜离子都采取扭曲的八面体配位构型,分别来自三唑配体的4个氮原子和2个氯原子配位。1和2都由分子间氢键连接成一维链结构。与相应的配体相比,1和2的抑菌活性明显增强。     

Synthesis, Characterization, Spectroscopy and Study of Antimicrobial Properties of Two New Substituted Trichloroaluminate（Ⅲ） Complexes [AlCl3X]- （X = SCN-, CN-）

The synthesis and characterization of two new aluminate(Ⅲ) complexes with general formula K[AlCl3X] are reported. These compounds derived from aluminate trichloride and related salts. Potassium trichlorothiocyanoaluminate, PCTA, and potassium trichlorocyanatoalu-minate, PCCA, are two new ionic aluminate complexes. They can be easily synthesized in a nearly quantitative yield by using the direct reaction of AlCl3 and KX. The complexes were characterized by physico-chemical and spectroscopic methods. Theoretical calculations have been used for the extraction of structural and spectroscopic data of these new synthesized complexes. The antibacterial activities of such compounds were studied against the Staphylococcus aureus, Escherichia coli, Staphylococcus Epidermidis, Estreptococo B and Shigella.     

2-(2,4-二氟苯基)-1-(4-烃基派嗪-1-基)-3-(1,2,4-三唑-1-基)-2-丙醇类化合物的合成及抗真菌活性

近20年来,真菌感染特别是深部真菌感染日益引起人们的广泛关注[1]。三唑类抗真菌药物对真菌的选择性较高,代谢稳定,体内动态、安全性都较好,已成为目前抗真菌药物研究开发的重点[2]。三唑类抗真菌药物是细胞色素P450 14α 去甲基酶的抑制剂,可影响该酶所催化的真菌麦角甾醇的生物合成,导致真菌细胞膜破损而死亡[3,4]。1998年,SynPhar实验室及Taiho制药公司[5]研制开发的化合物Syn 2869采用了取代哌嗪作为侧链。体外实验表明,该化合物抗菌谱广,对多种念珠菌、隐球菌及曲莓菌均有效,体内实验中,与目前临床上治疗真菌感染的主要用药伊曲…     

2-烷氧基-4H-咪唑啉-4-酮衍生物的合成与杀菌活性

应用烯基膦亚胺（1）与芳基异氰酸酯的氮杂Wittig反应，得到的碳二亚胺2再 与醇在醇钠催化下反应，合成了新的2-烷氧基-4H-咪唑啉-4-酮衍生物（3），探讨 了成环反应的条件以及所合成的新型杂环化合物的杀菌活性，结果表明部分化合物 表现出较好的抑菌活性，其中以3b活性最好，在50 mg/L浓度时，对水稻纹枯菌和 苹果轮纹菌的抑制率达81%以上。     

超氧化物歧化酶模型化合物的合成, 表征和活性测定

合成了二(2-苯并咪唑亚甲基)胺(N3)及其四种全新的过渡金属的双核配合物。通过元素分析、红外光谱和紫外光谱对配体及配合物进行了结构表征,利用邻苯三酚自氧化法测定了四种模拟化合物催化超氧阴离子自由基歧化反应的活性。     

Phytochemical,cytotoxic and chemotaxonomic study on Ajuga forrestii Diels (Labiatae)

A phytochemical investigation of Ajuga forrestii Diels led to the isolation of 14 compounds, including eight neo-clerodane diterpenes (1–8), two phytoecdysteroids (9, 11), one stigmastane sterol (10) and three iridoid glycosides (12–14). The structures of these compounds were identified by spectroscopic methods and a comparison of their data with those reported in the literature. This is the first report of compounds 1–14 from A. forrestii. The cytotoxic activities of the aqueous extract of A. forrestii and several compounds have been studied and the chemotaxonomic significance of isolated compounds has also been summarised.     

Computational Drug Repurposing Based on a Recommendation System and Drug–Drug Functional Pathway Similarity

Drug repurposing identifies new clinical indications for existing drugs. It can be used to overcome common problems associated with cancers, such as heterogeneity and resistance to established therapies, by rapidly adapting known drugs for new treatment. In this study, we utilized a recommendation system learning model to prioritize candidate cancer drugs. We designed a drug–drug pathway functional similarity by integrating multiple genetic and epigenetic alterations such as gene expression, copy number variation (CNV), and DNA methylation. When compared with other similarities, such as SMILES chemical structures and drug targets based on the protein–protein interaction network, our approach provided better interpretable models capturing drug response mechanisms. Furthermore, our approach can achieve comparable accuracy when evaluated with other learning models based on large public datasets (CCLE and GDSC). A case study about the Erlotinib and OSI-906 (Linsitinib) indicated that they have a synergistic effect to reduce the growth rate of tumors, which is an alternative targeted therapy option for patients. Taken together, our computational method characterized drug response from the viewpoint of a multi-omics pathway and systematically predicted candidate cancer drugs with similar therapeutic effects.     

Secondary Metabolites with Anti-Inflammatory from the Roots of Cimicifuga taiwanensis

The genus Cimicifuga is one of the smallest genera in the family Ranunculaceae. Cimicifugae Rhizoma originated from rhizomes of Cimicifuga simplex, and C. dahurica, C. racemosa, C. foetida, and C. heracleifolia have been used as anti-inflammatory, analgesic and antipyretic remedies in Chinese traditional medicine. Inflammation is related to many diseases. Cimicifuga taiwanensis was often used in folk therapy in Taiwan for inflammation. Phytochemical investigation and chromatographic separation of extracts from the roots of Cimicifuga taiwanensis has led to the isolation of six new compounds: cimicitaiwanins A–F (1–6, respectively). The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic data analysis (1D- and 2D-NMR, MS, and UV) and comparison with the literature data. The effect of some isolates on the inhibition of NO production in lipopolysaccharide-activated RAW 264.7 murine macrophages was evaluated. Of the isolates, 3–6 exhibited potent anti-NO production activity, with IC₅₀ values ranging from 6.54 to 24.58 μM, respectively, compared with that of quercetin, an iNOS inhibitor with an IC₅₀ value of 34.58 μM. This is the first report on metabolite from the endemic Taiwanese plant-C. taiwanensis.