The shuttle dispatch problem with compound Poisson arrivals: Controls at two terminals

We consider the control of an infinite capacity shuttle which transports passengers between two terminals. The passengers arrive at each terminal according to a compound Poisson process and the travel time from one terminal to the other is a random variable following an arbitrary distribution. The following control limit policy is considered: dispatch the shuttle at terminali, at the instant that the total number of passengers waiting at terminali reaches or exceeds a predetermined control limitm _i . The objective of this paper is to obtain the mean waiting time of an arbitrary passenger at each terminal for given control valuesm ₁ andm ₂. We also discuss a search procedure to obtain the optimal control values which minimize the total expected cost per unit time under a linear cost structure.     

Markovian queues with Poisson control

We investigate Markovian queues that are examined by a controller at random times determined by a Poisson process. Upon examination, the controller sets the service speed to be equal to the minimum of the current number of customers in the queue and a certain maximum service speed; this service speed prevails until the next examination time. We study the resulting two-dimensional Markov process of queue length and server speed, in particular two regimes with time scale separation, specifically for infinitely frequent and infinitely long examination times. In the intermediate regime the analysis proves to be extremely challenging. To gain further insight into the model dynamics we then analyse two variants of the model in which the controller is just an observer and does not change the speed of the server.     

基于概率密度演化方法的随机结构可靠度分析

随机结构反应的概率密度演化方法能够给出随机荷载作用下随机结构反应的概率密度函数。在此基础上，根据给定的正常使用位移限值要求，直接进行积分给出了随机结构的正常使用可靠度及其失效概率。在实例分析中，与一类情况下的精确解答及基于反应正态分布假定的二阶矩方法分析结果进行了比较。研究表明：基于密度演化方法的随机结构可靠度分析具有很高的精度，而二阶矩方法的可靠度分析结果则往往具有一定的偏差，在失效概率较低时可能给出虚假的失效概率。     

耐磨环氧胶粘涂层冲蚀磨损特性的研究

本文对气固冲蚀和浆体冲蚀条件下耐磨环氧胶粘涂层的磨损特性进行了研究。结果表明,这种涂层的冲蚀磨损是由粘结剂的磨损和抗磨填料的磨损所组成;填料粒度和磨料粒度都对涂层的气固冲蚀磨损有影响,但在给定的试验条件下,填料粒度对涂层的浆体冲蚀磨损影响甚微。文章指出,耐磨环氧胶粘涂层在气固冲蚀和浆体冲蚀下的磨损机理相似,但磨损规律却有所不同;耐磨环氧胶粘涂层尤其适用于浆体冲蚀的场合,可以明显地提高机械过流部件的使用寿命。     

A near-infrared spectroscopy method to determine aminoglycosides in pharmaceutical formulations

The analytical determination of aminoglycosides in pharmaceutical formulations is very difficult due to the lack of chromophores or fluorophores. Several analytical methods have been developed along the years mainly based on derivatization reactions. The European Pharmacopeia (EP) and the United States Pharmacopeia (USP) describe a microbiological assay to the quantification of aminoglycosides. Near infrared spectroscopy (NIRS) can be used alternatively to analyse aminoglycosides without the need of derivatization reactions or other type of sample processing. A new NIRS based method was developed for the analysis of the aminoglycoside antibiotic neomycin. The method was developed with samples based on a commercial formulation containing neomycin sulphate and three excipients: lactose, talc and magnesium stearate. Synthetic and doped samples were manufactured for this purpose. Three lots of a commercial solid formulation were also used to assess the validity of the method to quantify neomycin sulphate in the industrial pharmaceutical product. The method proposes measurements in reflectance mode using a Fourier-transform near infrared (FT-NIR) spectrometer. Partial least squares regression was the multivariate method adopted to calibrate the NIR spectra with the neomycin sulphate mass fraction. The concentration of neomycin sulphate present in the commercial samples was confirmed by HPLC with pre-column derivatization with phenylisocyanate. Results show that neomycin sulphate was determined successfully in the commercial samples using the method calibrated with the doped samples (mass fraction error of 6.6%). Moreover, the synthetic samples were found to be unqualified to develop the method, producing a biased calibration.     

Evaluation of relative LC/MS response of metabolites to parent drug in LC/nanospray ionization mass spectrometry: potential implications in MIST assessment

There is an increasing demand for quantitative data on metabolite exposure triggered by regulatory guidances. This contribution describes the accuracy of nanoelectrospray ionization mass spectrometry response of drug compounds and their metabolites from biological matrices compared with radiometric quantification. This is a comprehensive investigation of a set of real-life pharmaceutical compounds in relevant matrices such as urine, bile, feces and plasma. The data suggest that nanoelectrospray mass spectrometry can be used for semi-quantitation of metabolites in the absence of reference standards. Therefore, this approach is suitable to screen out non-relevant metabolites early in development as long as an adequate analytical error margin is applied thus balancing risks and resources.     

基于景气跟踪图的经济景气分析方法

首次将景气跟踪图方法引入中国经济景气分析中,并从宏观经济和行业分析两个维度对中国经济景气情况进行了分析.景气跟踪图方法基于时钟分析方法,对多个重要的经济时间序列指标的发展、运行进行跟踪,进而分析国民经济运行状态.景气跟踪图方法是一种新的景气分析方法,目前多用于宏观经济分析,作者尝试将其引入到行业分析中.针对直接采用原有景气跟踪图可能存在的问题,作者结合先行指标体系进行景气跟踪图分析,同时提出了基于景气跟踪图的经济持久期分析方法.中国经济的实证结果表明改进的景气跟踪图方法在宏观经济与行业分析中均有非常良好的表现,是现有景气分析方法的很好改进与补充.     

甘肃省物流业与经济发展的协调性评价分析

介绍了甘肃省物流业的实际状况,其次建立了甘肃省经济发展和甘肃省物流业发展的二级评价指标体系,运用基于方差加权法与熵值法相结合的综合赋权法的非线性评价模型分别对甘肃省经济发展的综合实力和物流业发展的综合实力进行评价.最后基于回归和隶属度函数相结合的方法,运用物流业和经济发展的综合实力评价结果分析计算甘肃省物流系统与经济系统的协调测度,根据计算的测度绘制散点图,对甘肃省物流系统与经济系统的协调度进行分析评价.     

Forensic examination of ink by high-performance thin layer chromatography--the United States Secret Service Digital Ink Library

Forensic examinations of ink have been performed since the beginning of the 20th century. Since the 1960s, the International Ink Library, maintained by the United States Secret Service, has supported those analyses. Until 2009, the search and identification of inks were essentially performed manually. This paper describes the results of a project designed to improve ink samples' analytical and search processes. The project focused on the development of improved standardization procedures to ensure the best possible reproducibility between analyses run on different HPTLC plates. The successful implementation of this new calibration method enabled the development of mathematical algorithms and of a software package to complement the existing ink library.     

服役环境下腐蚀坑等效为表面裂纹的有效性分析

对取自退役飞机机翼蒙皮的光滑试件进行了等幅疲劳试验,通过疲劳断口分析得到了服役环境下飞机主体材料LY12CZ 铝合金蚀坑的拓扑特征.基于飞机结构的实际腐蚀尺寸,将蚀坑的宽度和深度作为等效裂纹的长轴和短轴,并应用 Stress Check 软件对蚀坑等效为裂纹的可行性进行了有限元分析.结果表明:实际蚀坑与等效裂纹对结构应力分布的影响十分相似;应力强度因子在蚀坑等效前后数值大小和变化趋势不大.在分析蚀坑对典型试件疲劳寿命影响时将蚀坑等效成半椭圆形裂纹,选取 Walker 公式作为扩展速率模型,并与试验值进行了对比.结果表明:预测值与试验值比较吻合,最大误差为9.23%,满足工程需求.