Controllability of the wave equation with moving point control

This paper deals with approximate and exact controllability of the wave equation in finite time with interior point control acting along a curve specified in advance in the system's spatial domain. The structure of the control input is dual to the structure of the observations which describe the measurements of velocity and gradient of the solution of the dual system, obtained from the moving point sensor. A relevant formalization of such a control problem is discussed, based on transposition. For any given timeinterval [0,T] the existence of the curves providing approximate controllability inH _D ^–[n/2]–1 ()×H _D ^–[n/2]–1 () (wheren stands for the space dimension) is established with controls fromL ²(0,T; R ⁿ +1). The same curves ensure exact controllability inL ²() × H^–1() if controls are allowed to be selected in [L (0,T; R ⁿ+1)]. Required curves can be constructed to be continuous on [0,T).This work was supported in part by NSF Grant ECS 89-13773 and NASA Grant NAG-1-1081.     

Evaluation of micellar liquid chromatography and capillary zone electrophoresis for dope control in sport

Micellar liquid chromatography (MLC) and capillary zone electrophoresis (CZE) have been evaluated for the analysis of twelve banned drugs in sport including diuretics and -blockers. In MLC, a sodium dodecylsulphate aqueous solution has been used as mobile phase using an octadecylsilica column. In CZE, a pH 8 buffer solution and a silica capillary have been employed. Parameters of retention and efficiency have been compared. Limits of detection with UV detection at 254 nm and relative standard deviations for atenolol, furosemide, nadolol, spironolactone and triamterene were established and compared in both techniques. Examples of direct urine injection into the separation systems are presented. Drugs overlapping in MLC are well resolved in CZE, while the opposite is true for a limited number of drugs. Some interferences from urine may arise in CZE. The selectivity of analysis would be greatly enhanced by using both techniques, which require only filtration as pre-treatment.     

Langevin dynamic simulation of hysteresis in a field-swept Landau potential

Numerical simulations are done of Langevin dynamics for a uniform-orderparameter, field-swept Landau model,= –|a/2|m ²+|b/4|m ⁴–mh(t) , to study hysteresis effects. The field is swept at a constant rateh(t)=h(0)+ht. The stochastic jump values of the field {h_J from an initially prepared metastable minimumm(0) are recorded, on passage to a global minimum m(). The results are: (a) The mean jump¯h _J(h) increases (hysteresis loop widens) with h, confirming a previous theoretical criterion based on rate competition between field-sweep and inverse mean first-passage time (FPT); (b) The broad jump distribution(h _J,h) is related to intrinsically large FPT fluctuations ( ²–²)/ ² O(1), and can be quantitatively understood. Possible experimental tests of the ideas are indicated.     

Rapid dissolution procedure for base-metals-bearing complex materials for quality control assessment

A less labour-intensive method, involving a mixture of 1.0 g MnO₂ + 20 mL HCl (11), is proposed for decomposing seven ores and six metallurgical products for accurate and precise estimation of copper, lead, zinc, cobalt and nickel for quality control assessment. Twentyone international reference materials were also analysed. Results of regression analyses are presented and intermethod comparison studies reveal that the probability of results being different compared with a reference method was less than 1%. Sample decomposition is straightforward and the method has been found to be very simple, rapid and easily adaptable, as it involves no separation of the analyte from the matrix elements.     

Quality assurance and statistical control

In scientific research laboratories it is rarely possible to use quality assurance schemes, developed for large-scale analysis. Instead methods have been developed to control the quality of modest numbers of analytical results by relying on statistical control: Analysis of precision serves to detect analytical errors by comparing thea priori precision of the analytical results with the actual variability observed among replicates or duplicates. The method relies on the chi-square distribution to detect excess variability and is quite sensitive even for 5–10 results. Interference control serves to detect analytical bias by comparing results obtained by two different analytical methods, each relying on a different detection principle and therefore exhibiting different influence from matrix elements; only 5–10 sets of results are required to establish whether a regression line passes through the origo. Calibration control is an essential link in the traceability of results. Only one or two samples of pure solid or aqueous standards with accurately known content need to be analyzed. Verification is carried out by analyzing certified reference materials from BCR, NIST, or others; their limited accuracy of 5–10% make them less suitable for calibration purposes.     

High solids content emulsion terpolymerization of vinyl acetate,methyl methacrylate and butyl acrylate. II. Open loop composition control

A method for the calculation of the optimal monomer addition policies for polymer composition control in emulsion terpolymerization is developed. The method is applied to reactors with and without limited heat removal capacity. A mathematical model that incorporates the main features of the vinyl acetate/methyl methacrylate/butyl acrylate high solids content emulsion terpolymerization system allows the calculation of the composition of the initial charge of the reactor and the time-dependent monomer addition rates required. © 1994 John Wiley & Sons, Inc.     

Evaluation of the limit of performance of an analytical method based on a statistical calculation of its critical concentrations according to ISO standard 11843: Application to routine control of banned veterinary drug residues in food according to European Decision 657/2002/EC

Traceability of the measurement of analytical parameters capable of evaluating the performance of methods is an important concept for the assessment of quality for the routine control, especially for residue monitoring of non-authorized medicinal substances in food from animal origin. The European Decision no. 657/2002/EC recommends to calculate two statistical limits, CCα and CCβ, which allow to evaluate the critical concentrations above which the method reliably distinguish and quantify a substance taking into account the variability of the method and the statistical risk to take a wrong decision. The calculation, which can be derived from the ISO standard no. 11843 is applied on a routine basis. An example displays a very simple way for evaluating the performance of an LC-MSMS method which has been validated a few years ago and is qualified onto a Micromass Quattro LCZ tandem mass spectrometer to monitor and confirm the nitrofuran metabolite residues in food from animal origin. Community Reference Laboratory for Antimicrobial Veterinary Drug Residue Control in Food from Animal Origin     

A discrete method of optimal control based upon the cell state space concept

A discrete method of optimal control is proposed in this paper. The continuum state space of a system is discretized into a cell state space, and the cost function is discretized in a similar manner. Assuming intervalwise constant controls and using a finite set of admissible control levels (u) and a finite set of admissible time intervals (), the motion of the system under all possible interval controls (u, ) can then be expressed in terms of a family of cell-to-cell mappings. The proposed method extracts the optimal control results from these mappings by a systematic search, culminating in the construction of a discrete optimal control table.The possibility of expressing the optimal control results in the form of a control table seems to give this method a means to make systems real-time controllable.Dedicated to G. LeitmannThe material is based upon work supported by the National Science Foundation under Grant No. MEA-82-17471. The author is also indebted to Professor G. Leitmann for his many helpful comments.     

药用缓释辅料——羟丙基甲基纤维素的合成及其缓释性能的研究

本文研究了药物缓释材料HPMC的合成方法,探讨了碱纤维素制备,醚化剂浓度,混合醚化剂配经以及产品后处理对高粘度HPMC的影响。本文还初步对KCl,氨茶碱,硝酸异山梨醇酯等药物采用合成的HPMC作辅料,进行了缓释制剂的研究,结果表明合成的HPMC具有满意的缓释性能。     

Some non conventional devices with temperature control design and application

The development of a temperature control system based on semiconductor thermobatteries has been used in a set of devices for studying the martensitic transformation. The devices range from a simple stage for an optical microscope to a more elaborated system as a differential scanning calorimeter [1]. Here the attention is placed in this last system. The general problems of the temperature scanning calorimetry are reviewed from the signal theory point of view and the solutions applied to our system discussed. Some measurements are shown as an example of its application.