A Simple Method for Controlling the Degree of PEGylation of Dynorphin A (1-13)

Dynorphin A (1–13) was chemically modified by reaction with succinimidyl propionate‐monomethoxy polyethylene glycol (mPEG‐SPA). To determine the degree and the optimized condition for PEGylation of dynorphin A, the reactions were monitored in different pH buffers at different molar ratios by reversed‐phase high performance liquid chromatography (RP‐HPLC) and matrix‐assisted laser desorption/ionization time‐of‐?ight mass spectrometry (MALDI‐TOF MS). The results showed that the degree of PEGylation for dynorphin A could easily be controlled through adjustment of the molar ratios and the pH. The degree of PEGylation of dynorphin A increased as the molar ratio of dynorphin to MPEG‐SPA and the pH increased.     

An estimator of the tail index based on increment ratio statistics

In this paper, we introduce an increment ratio statistic (IR ^N,m ) based estimator for estimation of the tail index of a heavy-tailed distribution. For i.i.d. observations depending on the zone of attraction of an α-stable law (0 < α < 2), the IR ^N,m statistic converges to a decreasing function L(α) as both the sample size N and bandwidth parameter m tend to infinity. We obtain a rate of decay of the bias EIR ^N,m −L(α) and mean square error E(IR ^N,m −L(α))². A central limit theorem (IR ^N,m −EIR ^N,m )⟹ (0,σ²(α)) is also obtained. Monte Carlo simulations show that our tail index estimator has quite good empirical mean square error and, unlike the Hill estimator, is not so sensitive to a change of bandwidth parameter m. The research was partially supported by the Lithuanian State Science and Studies Foundation, grant No. T-25/08.     

The fractional chromatic number, the Hall ratio, and the lexicographic product

Let χ_f denote the fractional chromatic number and ρ the Hall ratio, and let the lexicographic product of G and H be denoted GlexH. Main results: (i) ρ(GlexH)≤χ_f(G)ρ(H); (ii) if ρ(G)=χ_f(G) then ρ(GlexH)=ρ(G)ρ(H) for all H; (iii) χ_f−ρ is unbounded. In addition, the question of how big χ_f/ρ can be is discussed.     

具有线性趋势的回归信度模型中的估计和检验

研究具有线性趋势回归信度模型的参数估计和检验. 对该模型的回归系数和随机效应的方差,利用正交变换法得到了它们的极大似然估计, 并得到了参数的无偏估计. 对随机效应和是否有线性趋势采用似然比检验, 得到了似然统计量较好的近似$P$值, 并对检验的功效进行了模拟研究.     

两台可拒绝同型机半在线排序问题

本文讨论一个两台可拒绝同型机半在线排序问题.当工件到达时,可以被拒绝,但要付出一定的罚值,也可以被接收加工,消耗一定的加工时间.其目标是要使所有加工工件生成的makespan和被拒绝工件的总罚值之和最小.加工不允许中断.进一步,机器带有两个并行处理子系统,可以提供两种排序方案,最后选取较好的一种.这是第一个在可拒绝同型机排序模型中使用半在线信息,我们设计出一个近似算法,其竞争比为3/2,另外又给出一个√3+1/2≈1.366的下界.     

SULFATION OF PACHYMAN WITH CHLOROSULFONIC ACID USING THE IMPROVED WOLFROM METHOD

High purity polysaccharide of pachyman was isolated from the powder of Poria cocos sclerotium with an yield of 77.8%. The intrinsic viscosity of polysaccharide was found to be 78.95 mL/g in DMSO solution at 25℃. The isolated polysaccharide was reacted with chlorosulfonic acid to obtain pachyman sulfate using the improved Wolfrom method. The results of the orthogonality experiment on the sulfation reaction identified that the effectiveness of the reaction conditions on the degree of sulfation and the value of intrinsic viscosity is in the following order: molar ratio of chlorosulfonic acid to glucoside (3-5) ＞ reaction temperature (60-80℃) ＞ reaction time (1-2 h). The kinetic studies of the pachyman sulfationindicated that the hydrolysis is accompanied with the sulfation process. The decrease in intrinsic viscosity of the sulfated pachyman is proportional to the increase in the degree of sulfation under the mild reaction conditions of ＜ 80℃,chlorosulfonic acid/glucoside mole ratio ＜ 5, and reaction time ＜ 2 h. Beyond the above reaction conditions, excessive loss of -OH group occurs during hydrolysis. The NMR results indicated a complete sulfation on C-6 and a partial sulfation on the C-2 and C-4 of glucoside.     

刚柔组合桩复合地基加固设计与应用

利用柔性桩减少刚性桩与土之间的刚度差,使之与土结合良好,达到提高复合地基承载力特征值和柔性桩软土地基加固的置换率、减少刚性桩复合地基变形及降低软地基处理造价等目的.将水泥土柔性短桩中心用沉管桩的工法施工低强度（C10）砼桩——＂刚柔组合桩＂的复合地基,处理宁波北仑某仓库的软土地基,经检测、计算验证和经济型比较,表明刚柔组合桩复合地基法可应用于软土地基工程,且能降低造价.     

丙烯酰胺与二甲基二烯丙基氯化铵共聚动力学

采用膨胀计法研究了以过硫酸铵 亚硫酸氢钠为引发剂,丙烯酰胺（AM）和二甲基二烯丙基氯化铵（DMDAAC）在水溶液中的共聚反应动力学,测定了相应的聚合表观活化能、聚合速率方程和单体竞聚率。 结果表明,当AM与DMDAAC摩尔比分别为5∶5、6∶4和7∶3时,表观活化能分别为Ea1=90.61 kJ/mol、Ea2=88.88 kJ/mol和Ea3=85.15 kJ/mol;聚合反应温度为45 ℃下,聚合速率方程分别为Rp1=kc(M)2.84c(IO)0.51·c(IR)0.61,Rp2=kc(M)2.77c(IO)0.51c(IR)0.59和Rp3=kc(M)2.73c(IO)0.50c(IR)0.56;2种单体的竞聚率分别为rAM=6.11,rDMDAAC=0.14。 上述实验结果可从动力学角度为不同阳离子度共聚物Poly(DMDAAC-co-AM)（PDA）聚合反应速率差别及产物特征黏度值差异进行解释。     

铜纳米薄片双轴应变弹性响应的第一性原理研究

近年来,在纳米尺度的研究中应用到很多表面的技术和概念.然而,以往针对表面的研究中对象为单晶块体样品,这些研究结果将不再适用纳米材料.为了研究表面对纳米体系弹性响应的影响,选取较为简单的铜纳米薄片为研究对象,构建了铜（111）面和（001）面的薄片模型,使用第一性原理方法计算了铜纳米薄片的双轴泊松比,分析了纳米薄片与体材料的差异,研究不同厚度纳米薄片中表面对内层原子的影响.计算结果显示,表面原子层的双轴泊松比大于内部原子层,并且其收敛速度和数值大小均和薄片取向有关.根据双轴泊松比随厚度的变化特性,可以得到不同取向的纳米薄片中表面对弹性响应的临界厚度.     

Stochastic resonance for a metapopulation system driven by multiplicative and additive colored noises

We investigate the stochastic resonance(SR) phenomenon induced by the periodic signal in a metapopulation system with colored noises. The analytical expression of signal-to-noise is derived in the adiabatic limit. By numerical calculation, the effects of the addictive noise intensity, the multiplicative noise intensity and two noise self-correlation times on SNR are respectively discussed. It shows that:(i) in the case that the addictive noise intensity M takes a small value, a SR phenomenon for the curve of SNR appears; however, when M takes a large value, SNR turns into a monotonic function on the multiplicative noise intensity Q.(ii) The resonance peaks in the plots of the multiplicative noise intensity Q versus its self-correlation time τ1 and the addictive noise intensity M versus its self-correlation time τ2 translate in parallel. Meanwhile, a parallel translation also appears in the plots of τ1 versus Q and τ2 versus M.(iii) The interactive effects between self-correlation times τ1 and τ2 are opposite.