基于样本库的人脸图像处理方法

本文给出了一种基于样本库的人脸图像超分辨率方法,这一方法结合了人脸图像全局相似性和局部特征相似性的约束.局部结构的相似性将超分辨率解约束到人脸局部结构空间,不同尺度上的局部相似性指导搜索最优解,然后将局部结构重建的人脸图像投影到由人脸图像确定的特征人脸空间.实验结果表明该算法得到的人脸具有很好的准确性和视觉效果.     

QSAR models of cytochrome P450 enzyme 1A2 inhibitors using CoMFA,CoMSIA and HQSAR

Quantitative structure–activity relationship (QSAR) studies were conducted on an in-house database of cytochrome P450 enzyme 1A2 inhibitors using the comparative molecular field analysis (CoMFA), comparative molecular similarity analysis (CoMSIA) and hologram QSAR (HQSAR) approaches. The database consisted of 36 active molecules featuring varied core structures. The model based on the naphthalene substructure alignment incorporating 19 molecules yielded the best model with a CoMFA cross validation value q² of 0.667 and a Pearson correlation coefficient r² of 0.976; a CoMSIA q² value of 0.616 and r² value of 0.985; and a HQSAR q² value of 0.652 and r² value of 0.917. A second model incorporating 34 molecules aligned using the benzene substructure yielded an acceptable CoMFA model with q² value of 0.5 and r² value of 0.991. Depending on the core structure of the molecule under consideration, new CYP1A2 inhibitors will be designed based on the results from these models.     

含氮杂环类润滑油添加剂CoMFA-QSTR及CoMSIA-QSTR抗磨损性能模型的构建

依据摩擦学定量构效关系理论(QSTR),采用比较分子力场分析(CoMFA)和比较分子相似性指数分析(CoMSIA)这两种方法研究了含氮杂环类润滑油添加剂的抗磨损性能的摩擦学三维定量构效关系(3D-QSTR),并建立了相应的3D-QSTR模型.结果表明:仅利用静电场构建CoMFA或CoMSIA模型时,模型预测能力最好,r~2,q~2均大于0.5.根据CoMFA或CoMSIA模型等高线图分析得出:分子静电场对含氮杂环类润滑油添加剂的抗磨损性能影响最大,在特定区域的引入带负电荷或带正电荷的基团将有助于抗磨性能的提高.     

Computational Drug Repurposing Based on a Recommendation System and Drug–Drug Functional Pathway Similarity

Drug repurposing identifies new clinical indications for existing drugs. It can be used to overcome common problems associated with cancers, such as heterogeneity and resistance to established therapies, by rapidly adapting known drugs for new treatment. In this study, we utilized a recommendation system learning model to prioritize candidate cancer drugs. We designed a drug–drug pathway functional similarity by integrating multiple genetic and epigenetic alterations such as gene expression, copy number variation (CNV), and DNA methylation. When compared with other similarities, such as SMILES chemical structures and drug targets based on the protein–protein interaction network, our approach provided better interpretable models capturing drug response mechanisms. Furthermore, our approach can achieve comparable accuracy when evaluated with other learning models based on large public datasets (CCLE and GDSC). A case study about the Erlotinib and OSI-906 (Linsitinib) indicated that they have a synergistic effect to reduce the growth rate of tumors, which is an alternative targeted therapy option for patients. Taken together, our computational method characterized drug response from the viewpoint of a multi-omics pathway and systematically predicted candidate cancer drugs with similar therapeutic effects.     

相似剩余格及其对应逻辑系统的完备性

引入了相似剩余格的概念,讨论了剩余格上相似算子和等价算子的关系,并得到了真值剩余格和相似剩余格相互转化的方法.其次,研究了相似剩余格上的相似滤子,利用相似滤子刻画了可表示的相似剩余格.最后,引入了相似剩余格对应的逻辑系统,证明了其完备性定理,并得到了其成为半线性逻辑的条件.     

A Class of Bidimensional FMRA Wavelet Frames

This paper addresses the construction of wavelet frame from a frame multiresolution analysis （FMRA） associated with a dilation matrix of determinant ±2. The dilation matrices of determinant ±2 can be classified as six classes according to integral similarity. In this paper, for four classes of them, the construction of wavelet frame from an FMRA is obtained, and, as examples, Shannon type wavelet frames are constructed, which have an independent value for their optimality in some sense.     

区间型多属性群体专家权重的确定方法

针对方案偏好和属性值均为区间数的多属性群决策问题,研究了群体专家权重的确定,并提出了一种新的群决策方法．通过定义区间数向量的内积,计算专家评判的相似度和差异度,进而客观地确定了专家的权重．求解最小化主、客观偏差的目标规划模型,得到了属性的权重,利用方案的群体综合属性值给出排序结果．供应商选择的应用实例验证了方法的可行性和合理性．     

一种多视点视频自动颜色校正系统

针对多视点视频系统中视点间图像颜色不一致的问题,提出了一种多视点视频自动颜色校正系统。通过求取目标图像和源图像间的颜色校正矩阵,判断其是否满足全局校正的要求;对不满足要求的图像,通过图像分割和K-L变换(Karhunen-Loeve transform),建立起目标图像和源图像中各分割区域间的局部映射关系,并通过感兴趣区域匹配,来实现对源图像的校正,最后通过视频跟踪技术实现对视频图像的校正。以标准的多视点测试图像集为例,通过将新方法与直方图匹配、全局一维线性校正算法等进行比较,表明新方法能消除匹配失真的影响,且具有较好的颜色校正效果。研究结果表明该系统可以很好地揭示图像间的颜色变化关系,并且具有很好的内容自适应性,是一种有效的多视点视频图像系统颜色校正方法。     

Software lens compensation applied to athermalization of infrared imaging systems

A different approach, aiming to achieve the constant blur status of point-spread function (PSF) at a certain defocused plane, is described. The correlation between the two PSF is used to control the PSF blur similarity, and simultaneously the Strehl ratio is also used to control the PSF blur minimization. By designing the PSF so that it is significantly insensitive to defocus or related defocus quantity, for example, due to temperature change, all the constantly blurred images can be accurately de-blurred by a simple inverse restoration filter for an adequate range of defocus. We refer to that as “software lens compensation” and apply a design method to solve the athermalization of middle wavelength infrared (MWIR) imaging systems. The resultant PSF is almost invariant in the temperature range from −10 to 50°C at the same focal plane. Consequently, the constant blur spot can be removed by a simple digital signal processing. Thus, clear and sharp de-blurred images at different temperatures are obtained.     

Segmentation of synthetic aperture radar image using multiscale information measure-based spectral clustering

A multiscale information measure （MIM）, calculable from per-pixel wavelet coefficients, but relying on global statistics of synthetic aperture radar （SAR） image, is proposed. It fully exploits the variations in speckle pattern when the image resolution varies from course to fine, thus it can capture the intrinsic texture of the scene backscatter and the texture due to speckle simultaneously. Graph spectral segmen- tation methods based on MIM and the usual similarity measure are carried out on two real SAR images. Experimental results show that MIM can characterize texture information of SAR image more effectively than the commonly used similarity measure.