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551.
Refining search terms for nanotechnology 总被引:5,自引:3,他引:2
Alan L. Porter Jan Youtie Philip Shapira David J. Schoeneck 《Journal of nanoparticle research》2008,10(5):715-728
The ability to delineate the boundaries of an emerging technology is central to obtaining an understanding of the technology’s
research paths and commercialization prospects. Nowhere is this more relevant than in the case of nanotechnology (hereafter
identified as “nano”) given its current rapid growth and multidisciplinary nature. (Under the rubric of nanotechnology, we
also include nanoscience and nanoengineering.) Past efforts have utilized several strategies, including simple term search
for the prefix nano, complex lexical and citation-based approaches, and bootstrapping techniques. This research introduces
a modularized Boolean approach to defining nanotechnology which has been applied to several research and patenting databases.
We explain our approach to downloading and cleaning data, and report initial results. Comparisons of this approach with other
nanotechnology search formulations are presented. Implications for search strategy development and profiling of the nanotechnology
field are discussed.
相似文献
Jan YoutieEmail: |
552.
Ester Giorgi Francesca Binacchi Carlo Marotta Damiano Cirri Chiara Gabbiani Alessandro Pratesi 《Molecules (Basel, Switzerland)》2023,28(1)
Although important progress has been made, cancer still remains a complex disease to treat. Serious side effects, the insurgence of resistance and poor selectivity are some of the problems associated with the classical metal-based anti-cancer therapies currently in clinical use. New treatment approaches are still needed to increase cancer patient survival without cancer recurrence. Herein, we reviewed two promising—at least in our opinion—new strategies to increase the efficacy of transition metal-based complexes. First, we considered the possibility of assembling two biologically active fragments containing different metal centres into the same molecule, thus obtaining a heterobimetallic complex. A critical comparison with the monometallic counterparts was done. The reviewed literature has been divided into two groups: the case of platinum; the case of gold. Secondly, the conjugation of metal-based complexes to a targeting moiety was discussed. Particularly, we highlighted some interesting examples of compounds targeting cancer cell organelles according to a third-order targeting approach, and complexes targeting the whole cancer cell, according to a second-order targeting strategy. 相似文献
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554.
Louise Malm Emma Palm Amina Souihi Merle Plassmann Jaanus Liigand Anneli Kruve 《Molecules (Basel, Switzerland)》2021,26(12)
Non-targeted screening (NTS) with reversed phase liquid chromatography electrospray ionization high resolution mass spectrometry (LC/ESI/HRMS) is increasingly employed as an alternative to targeted analysis; however, it is not possible to quantify all compounds found in a sample with analytical standards. As an alternative, semi-quantification strategies are, or at least should be, used to estimate the concentrations of the unknown compounds before final decision making. All steps in the analytical chain, from sample preparation to ionization conditions and data processing can influence the signals obtained, and thus the estimated concentrations. Therefore, each step needs to be considered carefully. Generally, less is more when it comes to choosing sample preparation as well as chromatographic and ionization conditions in NTS. By combining the positive and negative ionization mode, the performance of NTS can be improved, since different compounds ionize better in one or the other mode. Furthermore, NTS gives opportunities for retrospective analysis. In this tutorial, strategies for semi-quantification are described, sources potentially decreasing the signals are identified and possibilities to improve NTS are discussed. Additionally, examples of retrospective analysis are presented. Finally, we present a checklist for carrying out semi-quantitative NTS. 相似文献
555.